Expression And Epigenetic Regulation Of Dact1 And Dact2 In Oral Squamous Cell Carcinoma

dc.creatorSchussel
dc.creatorJuliana Lucena; Kalinke
dc.creatorLuciana Puchalski; Sassi
dc.creatorLaurindo Moacir; de Oliveira
dc.creatorBenedito Valdecir; Pedruzzi
dc.creatorPaola A. G.; Olandoski
dc.creatorMarcia; Alvares
dc.creatorLucia Elvira; Garlet
dc.creatorGustavo Pompermaier; Trevilatto
dc.creatorPaula Cristina
dc.date2015
dc.date2016-06-07T13:33:04Z
dc.date2016-06-07T13:33:04Z
dc.date.accessioned2018-03-29T01:48:50Z
dc.date.available2018-03-29T01:48:50Z
dc.identifier
dc.identifierExpression And Epigenetic Regulation Of Dact1 And Dact2 In Oral Squamous Cell Carcinoma. Ios Press, v. 15, p. 11-17 2015.
dc.identifier1574-0153
dc.identifierWOS:000346079800002
dc.identifier10.3233/CBM-140436
dc.identifierhttp://content.iospress.com/articles/cancer-biomarkers/cbm00436
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243610
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1307308
dc.descriptionBACKGROUND: DACT genes regulates Wnt as well TGF-beta pathway, and were already associated with hepatocellular and lung cancer. Alterations on Wnt/beta-catenin were associated with head and neck cancer through beta-catenin cytoplasmatic accumulation. OBJECTIVE: The aim of the study was to evaluate DACT1 and DACT2 expression and methylation on oral squamous cell cancer (OSCC). METHODS: 47 samples of salivary rinse and tissue were collected from 29 OSCC and 18 control patients. qMSP and RT-PCR reactions were performed in order to detect hypermethylation and expression of DACT1 and DACT2 genes. Statistical analysis was conducted to evaluate these genes as possible biomarkers for OSCC. RESULTS: As expected man over 60 years old with tobacco and alcohol consumption history were associated with OSCC. There was no statistical difference between groups concerning DACT1 and DACT2 either in promoter hypermethylation or transcript levels. Age was associated with DACT2 promoter hypermethylation, especially over 56 years old. CONCLUSION: Patients older than 56 years old were about 5 times more likely to have DACT2 promoter hypermethylation. These findings could partially explain why older subjects are more prone to carcinogenesis. Wnt/beta-catenin pathway plays an important role in carcinogenesis, and the study of their regulators may help understand malignant transformation.
dc.description15
dc.description1
dc.description
dc.description11
dc.description17
dc.descriptionNational Council for Scientific and Technological Development [500078/2011-4]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherIOS PRESS
dc.publisher
dc.publisherAMSTERDAM
dc.relationCANCER BIOMARKERS
dc.rightsfechado
dc.sourceWOS
dc.subjectTgf-beta
dc.subjectPromoter Hypermethylation
dc.subjectHepatocellular-carcinoma
dc.subjectSalivary Rinses
dc.subjectNeck-cancer
dc.subjectHead
dc.subjectCatenin
dc.subjectMethylation
dc.subjectDegradation
dc.subjectInvolvement
dc.titleExpression And Epigenetic Regulation Of Dact1 And Dact2 In Oral Squamous Cell Carcinoma
dc.typeArtículos de revistas


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