Dexamethasone/povidone Eye Drops Versus Artificial Tears For Treatment Of Presumed Viral Conjunctivitis: A Randomized Clinical Trial

dc.creatorPacheco Pinto
dc.creatorRoberto Damian; Cavalcanti Lira
dc.creatorRodrigo Pessoa; Abe
dc.creatorRicardo Yuji; Zacchia
dc.creatorRafael Santos; Fernandes Felix
dc.creatorJoao Paulo; Fernandes Pereira
dc.creatorAndre Venancio; Leite Arieta
dc.creatorCarlos Eduardo; de Castro
dc.creatorRosane Silvestre; Alves Bonon
dc.creatorSandra Helena
dc.date2015
dc.date2016-06-07T13:32:47Z
dc.date2016-06-07T13:32:47Z
dc.date.accessioned2018-03-29T01:48:33Z
dc.date.available2018-03-29T01:48:33Z
dc.identifier
dc.identifierDexamethasone/povidone Eye Drops Versus Artificial Tears For Treatment Of Presumed Viral Conjunctivitis: A Randomized Clinical Trial. Taylor & Francis Inc, v. 40, p. 870-877 2015.
dc.identifier0271-3683
dc.identifierWOS:000361327200002
dc.identifier10.3109/02713683.2014.964419
dc.identifierhttp://www.tandfonline.com/doi/abs/10.3109/02713683.2014.964419?journalCode=icey20#.VypPStIrLcc
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243541
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1307239
dc.descriptionPurpose: To determine whether topical dexamethasone 0.1%/povidone-iodine 0.4% reduces the duration of presumed viral conjunctivitis better than artificial tears and whether the treatment relieves the symptoms of this disease. Methods: Randomized, masked and controlled trial. One-hundred twenty-two patients with a clinical diagnosis of presumed viral conjunctivitis were randomized to either the treatment group or the control group. Physicians and patients were masked to the treatment. Swabs were taken from the conjunctival fornix for adenovirus PCR analyses. Patients in the treatment group received topical dexamethasone 0.1%/povidone-iodine 0.4% eye drops four times daily, and patients in the placebo group received artificial tears four times daily, both for seven days. Symptoms were recorded on the day of recruitment and at the time of a follow-up examination 5, 10 and 30 d later. The main outcome was duration of the disease. The others outcomes were overall discomfort, itching, foreign body sensation, tearing, redness, eyelid swelling, side effects of the eye drops, intraocular pressure and the incidence of subepithelial corneal infiltrates. Results: There was no statistically significant difference between the treatment group and the control group in terms of the patients' symptoms, intraocular pressure and incidence of subepithelial cornea infiltrates during the entire follow-up period. Patients of the treatment group reported more stinging (p<0.001) and a shorter conjunctivitis duration (9.4 +/- 4.6 d in the dexamethasone 0.1%/povidone-iodine 0.4% group versus 11.8 +/- 4.9 d in the artificial tears group, p = 0.009). Conclusions: The use of topical dexamethasone 0.1%/povidone-iodine 0.4% eye drops four times daily appears to reduce the duration of conjunctivitis, although it causes more stinging than artificial tears.
dc.description40
dc.description9
dc.description
dc.description870
dc.description877
dc.descriptionOphthalmos S/A, Sao Paulo, Brazil
dc.description
dc.description
dc.description
dc.languageen
dc.publisherTAYLOR & FRANCIS INC
dc.publisher
dc.publisherPHILADELPHIA
dc.relationCURRENT EYE RESEARCH
dc.rightsembargo
dc.sourceWOS
dc.subjectPolymerase-chain-reaction
dc.subjectOcular Adenovirus Infection
dc.subjectPovidone-iodine
dc.subjectBenzalkonium Chloride
dc.subjectEpidemic Keratoconjunctivitis
dc.subjectIn-vitro
dc.subjectChlamydia-trachomatis
dc.subjectHealthy-volunteers
dc.subjectCataract-surgery
dc.subjectCorticosteroids
dc.titleDexamethasone/povidone Eye Drops Versus Artificial Tears For Treatment Of Presumed Viral Conjunctivitis: A Randomized Clinical Trial
dc.typeArtículos de revistas


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