Interlocked Systems In Nanomedicine

dc.creatorOrnelas-Megiatto
dc.creatorCatia; Becher
dc.creatorTiago B.; Megiatto
dc.creatorJackson D.
dc.creatorJr.
dc.date2015
dc.date2016-06-07T13:32:40Z
dc.date2016-06-07T13:32:40Z
dc.date.accessioned2018-03-29T01:48:27Z
dc.date.available2018-03-29T01:48:27Z
dc.identifier
dc.identifierInterlocked Systems In Nanomedicine. Bentham Science Publ Ltd, v. 15, p. 1236-1256 2015.
dc.identifier1568-0266
dc.identifierWOS:000353654700007
dc.identifier10.2174/1568026615666150330111614
dc.identifierhttp://benthamscience.com/journals/current-topics-in-medicinal-chemistry/volume/15/issue/13/page/1236/
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243514
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1307212
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionThe concept of Nanomedicine emerged along with the new millennium, and it is expected to provide solutions to some of modern medicine's unsolved problems. Nanomedicine offers new hopes in several critical areas such as cancer treatment, viral and bacterial infections, medical imaging, tissue regeneration, and theranostics. To explore all these applications, a wide variety of nanomaterials have been developed which include liposomes, dendrimers, nanohydrogels and polymeric, metallic and inorganic nanoparticles. Recently, interlocked systems, namely rotaxanes and catenanes, have been incorporated into some of these chemical platforms in an attempt to improve their performance. This review focus on the nanomedicine applications of nanomaterials containing interlocked structures. The introduction gives an overview on the significance of interdisciplinary science in the progress of the nanomedicine field, and it explains the evolution of interlocked molecules until their application in nanomedicine. The following sections are organized by the type of interlocked structure, and it comprises details of the in vitro and/or in vivo experiments involving each material: rotaxanes as imaging agents, rotaxanes as cytotoxic agents, rotaxanes as peptide transporters, mechanized silica nanoparticles as stimuli responsive drug delivery systems, and polyrotaxanes as drug and gene delivery systems.
dc.description15
dc.description13
dc.description
dc.description1236
dc.description1256
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFAPESP [2013/11519-7, 2013/22160-0]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.publisher
dc.publisherSHARJAH
dc.relationCURRENT TOPICS IN MEDICINAL CHEMISTRY
dc.rightsfechado
dc.sourceWOS
dc.subjectCyclodextrin-based Polyrotaxanes
dc.subjectSustained-release System
dc.subjectControlled Drug-release
dc.subjectMesoporous Silica Nanoparticles
dc.subjectGene Delivery
dc.subjectIn-vitro
dc.subjectBiomedical Applications
dc.subjectAlpha-cyclodextrin
dc.subjectMolecular Machines
dc.subjectSupramolecular Hydrogels
dc.titleInterlocked Systems In Nanomedicine
dc.typeArtículos de revistas
dc.typeResumo


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