Mechanisms Of Insulin Resistance In The Amygdala: Influences On Food Intake

dc.creatorCondes Areias
dc.creatorMaria Fernanda; Prada
dc.creatorPatricia Oliveira
dc.date2015-APR
dc.date2016-06-07T13:23:14Z
dc.date2016-06-07T13:23:14Z
dc.date.accessioned2018-03-29T01:42:43Z
dc.date.available2018-03-29T01:42:43Z
dc.identifier
dc.identifierMechanisms Of Insulin Resistance In The Amygdala: Influences On Food Intake. Elsevier Science Bv, v. 282, p. 209-217 APR-2015.
dc.identifier0166-4328
dc.identifierWOS:000350186000025
dc.identifier10.1016/j.bbr.2015.01.003
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0166432815000078
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243350
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1307048
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionObesity is increasing worldwide and is triggered, at least in part, by enhanced caloric intake. Food intake is regulated by a complex mechanism involving the hypothalamus and hindbrain circuitries. However, evidences have showing that reward systems are also important in regulating feeding behavior. In this context, amygdala is considered a key extra-hypothalamic area regulating feeding behavior in human beings and rodents. This review focuses on the regulation of food intake by amygdala and the mechanisms of insulin resistance in this brain area. Similar to the hypothalamus the anorexigenic effect of insulin is mediated via PI3K (phosphoinositide 3-kinase)/Akt (protein kinase B) pathway in the amygdala. Insulin decreases NPY (neuropeptide Y) and increases oxytocin mRNA levels in the amygdala. High fat diet and saturated fatty acids induce inflammation, ER (endoplasmic reticulum) stress and the activation of serine kinases such as PKC theta (protein kinase C theta), JNK (c-Jun N-terminal kinase) and IKKP (inhibitor of nuclear factor kappa-B kinase beta) in the amygdala, which have an important role in insulin resistance in this brain region. Overexpressed PKCO in the CeA (central nucleus of amygdala) of rats increases weight gain, food intake, insulin resistance and hepatic triglycerides content. The inhibition of ER stress ameliorates insulin action/signaling, increases oxytocin and decreases NPY gene expression in the amygdala of high fat feeding rodents. Those data suggest that PKCO and ER stress are main mechanisms of insulin resistance in the amygdala of obese rats and play an important role regulating feeding behavior. (C) 2015 Elsevier B.V. All rights reserved.
dc.description282
dc.description
dc.description
dc.description209
dc.description217
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionSao Paulo, Brazil
dc.descriptionINCT (Instituto Nacional Ciencia e Tecnologia em Obesidade e Diabetes) [573856/2008-7]
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2012/10338-6, CEPID 2013/07607-8]
dc.descriptionCNPq [481084/2013-4]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherELSEVIER SCIENCE BV
dc.publisher
dc.publisherAMSTERDAM
dc.relationBEHAVIOURAL BRAIN RESEARCH
dc.rightsembargo
dc.sourceWOS
dc.subjectEndoplasmic-reticulum Stress
dc.subjectDiet-induced Obesity
dc.subjectEnergy Homeostasis
dc.subjectBody-weight
dc.subjectRat-brain
dc.subjectOrbitofrontal Cortex
dc.subjectReceptor-binding
dc.subjectAdipose-tissue
dc.subjectNeurons
dc.subjectLeptin
dc.titleMechanisms Of Insulin Resistance In The Amygdala: Influences On Food Intake
dc.typeArtículos de revistas
dc.typeResumo


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