Antiproliferative Activity Of Flavonoids From Croton Sphaerogynus Baill. (euphorbiaceae)

dc.creatordos Santos
dc.creatorKatia Pereira; Motta
dc.creatorLucimar B.; Santos
dc.creatorDeborah Y. A. C.; Salatino
dc.creatorMaria L. F.; Salatino
dc.creatorAntonio; Pena Ferreira
dc.creatorMarcelo J.; Lago
dc.creatorJoao Henrique G.; Ruiz
dc.creatorAna Lucia T. G.; de Carvalho
dc.creatorJoao E.; Furlan
dc.creatorClaudia M.
dc.date2015
dc.date2016-06-07T13:22:58Z
dc.date2016-06-07T13:22:58Z
dc.date.accessioned2018-03-29T01:42:28Z
dc.date.available2018-03-29T01:42:28Z
dc.identifier
dc.identifierAntiproliferative Activity Of Flavonoids From Croton Sphaerogynus Baill. (euphorbiaceae). Hindawi Publishing Corporation, p. 2015.
dc.identifier2314-6133
dc.identifierWOS:000355431600001
dc.identifier10.1155/2015/212809
dc.identifierhttp://www.hindawi.com/journals/bmri/2015/212809/
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243290
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306988
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCroton sphaerogynus is a shrub from the Atlantic Rain Forest in southeastern Brazil. A lyophilized crude EtOH extract from leaves of C. sphaerogynus, obtained by maceration at room temperature (seven days), was suspended in methanol and partitioned with hexane. The purified MeOH phase was fractionated over Sephadex LH-20 yielding five fractions (F1-F5) containing flavonoids, as characterized by HPLC-DAD and HPLC-MS analyses. The antiproliferative activity of the crude EtOH extract, MeOH and hexane phases, and fractions F1-F5 was evaluated on in vitro cell lines NCI-H460 (nonsmall cell lung), MCF-7 (breast cancer), and U251 (glioma). The MeOH phase showed activity (mean log GI(50) 0.54) higher than the hexane phase and EtOH extract (mean log GI(50) 1.13 and 1.19, resp.). F1 exhibited activity against NCI-H460 (nonsmall cell lung) (GI(50) 1.2 mu g/mL), which could be accounted for the presence of flavonoids and/or diterpenes. F4 showed moderate activity (mean log GI(50) 1.05), while F5 showed weak activity (mean log GI(50) 1.36). It is suggested that the antiproliferative activity of the crude EtOH extract and MeOH phase is accounted for a synergistic combination of flavonoids and diterpenes.
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dc.description
dc.description
dc.description
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFAPESP [FAPESP 2012/10079-0]
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dc.languageen
dc.publisherHINDAWI PUBLISHING CORPORATION
dc.publisher
dc.publisherNEW YORK
dc.relationBIOMED RESEARCH INTERNATIONAL
dc.rightsaberto
dc.sourceWOS
dc.subjectMull. Arg. Euphorbiaceae
dc.subjectAnticancer Drug Screen
dc.subjectLeukemia-cells
dc.subjectEssential Oil
dc.subjectIn-vitro
dc.subjectExtracts
dc.subjectLeaves
dc.subjectDiterpenes
dc.subjectCajucara
dc.subjectConstituents
dc.titleAntiproliferative Activity Of Flavonoids From Croton Sphaerogynus Baill. (euphorbiaceae)
dc.typeArtículos de revistas


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