Poloxamer-based Binary Hydrogels For Delivering Tramadol Hydrochloride: Sol-gel Transition Studies, Dissolution-release Kinetics, In Vitro Toxicity, And Pharmacological Evaluation

dc.creatorMendonca dos Santos
dc.creatorAna Claudia; Santos Akkari
dc.creatorAlessandra Cristina; Silva Ferreira
dc.creatorIasmin Rosanne; Maruyama
dc.creatorCintia Rodrigues; Pascoli
dc.creatorMonica; Guilherme
dc.creatorViviane Aparecida; de Paula
dc.creatorEneida; Fraceto
dc.creatorLeonardo Fernandes; de Lima
dc.creatorRenata; Melo
dc.creatorPatricia da Silva; de Araujo
dc.creatorDaniele Ribeiro
dc.date2015
dc.date2016-06-07T13:22:57Z
dc.date2016-06-07T13:22:57Z
dc.date.accessioned2018-03-29T01:42:28Z
dc.date.available2018-03-29T01:42:28Z
dc.identifier
dc.identifierPoloxamer-based Binary Hydrogels For Delivering Tramadol Hydrochloride: Sol-gel Transition Studies, Dissolution-release Kinetics, In Vitro Toxicity, And Pharmacological Evaluation. Dove Medical Press Ltd, v. 10, p. 2391-2401 2015.
dc.identifier1178-2013
dc.identifierWOS:000351616800001
dc.identifier10.2147/IJN.S72337
dc.identifierhttps://www.dovepress.com/poloxamer-based-binary-hydrogels-for-delivering-tramadol-hydrochloride-peer-reviewed-article-IJN
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243289
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306987
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIn this work, poloxamer (PL)-based binary hydrogels, composed of PL 407 and PL 188, were studied with regard to the physicochemical aspects of sol-gel transition and pharmaceutical formulation issues such as dissolution-release profiles. In particular, we evaluated the cytotoxicity, genotoxicity, and in vivo pharmacological performance of PL 407 and PL 407-PL 188 hydrogels containing tramadol (TR) to analyze its potential treatment of acute pain. Drug-micelle interaction studies showed the formation of PL 407-PL 188 binary systems and the drug partitioning into the micelles. Characterization of the sol-gel transition phase showed an increase on enthalpy variation values that were induced by the presence of TR hydrochloride within the PL 407 or PL 407-PL 188 systems. Hydrogel dissolution occurred rapidly, with approximately 30%-45% of the gel dissolved, reaching similar to 80%-90% up to 24 hours. For in vitro release assays, formulations followed the diffusion Higuchi model and lower K-rel values were observed for PL 407 (20%, K-rel = 112.9 +/- 10.6 mu g . h(-1/2)) and its binary systems PL 407-PL 188 (25%-5% and 25%-10%, K-rel = 80.8 +/- 6.1 and 103.4 +/- 8.3 mu g.h(-1/2), respectively) in relation to TR solution (K-rel = 417.9 +/- 47.5 mu g.h(-1/2), P<0.001). In addition, the reduced cytotoxicity (V79 fibroblasts and hepatocytes) and genotoxicity (V79 fibroblasts), as well as the prolonged analgesic effects (>72 hours) pointed to PL-based hydrogels as a potential treatment, by subcutaneous injection, for acute pain.
dc.description10
dc.description
dc.description
dc.description2391
dc.description2401
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2006/00121-9, 2010/11475-1, 2010/13088-5]
dc.descriptionCNPq [487619/2012-9, 300952/2010-4, 309612/2013-6]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherDOVE MEDICAL PRESS LTD
dc.publisher
dc.publisherALBANY
dc.relationINTERNATIONAL JOURNAL OF NANOMEDICINE
dc.rightsaberto
dc.sourceWOS
dc.subjectAqueous-solution
dc.subjectLidocaine
dc.subjectCopolymers
dc.subjectSystem
dc.subjectBlock
dc.subjectDrug
dc.subjectMicelles
dc.subjectGelation
dc.subjectRats
dc.subjectCopoly(oxyalkylene)s
dc.titlePoloxamer-based Binary Hydrogels For Delivering Tramadol Hydrochloride: Sol-gel Transition Studies, Dissolution-release Kinetics, In Vitro Toxicity, And Pharmacological Evaluation
dc.typeArtículos de revistas


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