Cancer Stem And Progenitor-like Cells As Pharmacological Targets In Breast Cancer Treatment

dc.creatorde Souza
dc.creatorValeria B.; Schenka
dc.creatorAndre A.
dc.date2015
dc.date2016-06-07T13:22:55Z
dc.date2016-06-07T13:22:55Z
dc.date.accessioned2018-03-29T01:42:26Z
dc.date.available2018-03-29T01:42:26Z
dc.identifier
dc.identifierCancer Stem And Progenitor-like Cells As Pharmacological Targets In Breast Cancer Treatment. Libertas Acad, v. 9, p. 45-55 2015.
dc.identifier1178-2234
dc.identifierWOS:000367888900005
dc.identifier10.4137/BCBCR.S29427
dc.identifierhttp://www.la-press.com/cancer-stem-and-progenitor-like-cells-as-pharmacological-targets-in-br-article-a5196
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243280
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306978
dc.descriptionThe present review is focused on the current role of neoplastic stem and progenitor-like cells as primary targets in the pharmacotherapy of cancer as well as in the development of new anticancer drugs. We begin by summarizing the main characteristics of these tumor-initiating cells and key concepts that support their participation in therapeutic failure. In particular, we discuss the differences between the major carcinogenesis models (ie, clonal evolution vs cancer stem cell (CSC) model) with emphasis on breast cancer (given its importance to the study of CSCs) and their implications for the development of new treatment strategies. In addition, we describe the main ways to target these cells, including the main signaling pathways that are more activated or altered in CSCs. Finally, we provide a comprehensive compilation of the most recently tested drugs.
dc.description9
dc.description
dc.description2
dc.description45
dc.description55
dc.description
dc.description
dc.description
dc.languageen
dc.publisherLIBERTAS ACAD
dc.publisher
dc.publisherAUCKLAND
dc.relationBREAST CANCER-BASIC AND CLINICAL RESEARCH
dc.rightsaberto
dc.sourceWOS
dc.subjectTumor-initiating Cells
dc.subjectMammosphere Formation
dc.subjectMyeloid-leukemia
dc.subjectSide-population
dc.subjectMammary-gland
dc.subjectSolid Tumors
dc.subjectLung-cancer
dc.subjectIn-vitro
dc.subjectTherapeutic Implications
dc.subjectMesenchymal Transition
dc.titleCancer Stem And Progenitor-like Cells As Pharmacological Targets In Breast Cancer Treatment
dc.typeArtículos de revistas


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