Superoxide Anion Radical: Generation And Detection In Cellular And Non-cellular Systems

dc.creatorChiste
dc.creatorRenan Campos; Freitas
dc.creatorMarisa; Mercadante
dc.creatorAdriana Zerlotti; Fernandes
dc.creatorEduarda
dc.date2015
dc.date2016-06-07T13:22:38Z
dc.date2016-06-07T13:22:38Z
dc.date.accessioned2018-03-29T01:42:13Z
dc.date.available2018-03-29T01:42:13Z
dc.identifier
dc.identifierSuperoxide Anion Radical: Generation And Detection In Cellular And Non-cellular Systems. Bentham Science Publ Ltd, v. 22, p. 4234-4256 2015.
dc.identifier0929-8673
dc.identifierWOS:000366483100001
dc.identifier10.2174/0929867322666151029104311
dc.identifierhttp://www.eurekaselect.com/136232/article
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243229
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306927
dc.descriptionThe production of superoxide anion radical (O-2 center dot(-)) is essential for the life of aerobic organisms. This free radical acts as a signaling molecule, regulating numerous biological processes including apoptosis, aging, and senescence. Nevertheless, when overproduction of O-2 center dot(-) occurs and/or antioxidant defences are deficient, oxidative stress may develop, damaging important biomolecules and altering their physiological function. These effects have been associated to the development of several diseases. Scavenging of O-2 center dot(-) has been used as a hallmark to test the antioxidant capacity of several types of compounds in cellular and non-cellular systems. However, despite the pathophysiological importance of O-2 center dot(-), the information about its endogenous and/or chemical generation and detection is dispersed and there are no reports that concisely cover the information in an integrated form. This gap can explain the limitations attributed to the currently used systems, namely in what concerns the selectivity, specificity and validation. This review attempts to provide a critical assessment of the available O-2 center dot(-) generating and detection, both in endogenous and chemical systems, scrutinizing its advantages and limitations in order to facilitate the choice and implementation of the O-2 center dot(-) generator and/or detection method that better fits the researchers' objectives.
dc.description22
dc.description37
dc.description
dc.description4234
dc.description4256
dc.descriptionFCT (Fundacao para a Ciencia e Tecnologia, Portugal) [UID/Multi/04378/2013, PTDC/QEQ-QAN/1742/2014]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFSE
dc.descriptionFCT [SFRH/BPD/76909/2011]
dc.descriptionnational funds of MCTES
dc.description
dc.description
dc.description
dc.languageen
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.publisher
dc.publisherSHARJAH
dc.relationCURRENT MEDICINAL CHEMISTRY
dc.rightsfechado
dc.sourceWOS
dc.subjectNitric-oxide Synthase
dc.subjectBis-n-methylacridinium
dc.subjectReactive Oxygen
dc.subjectXanthine-oxidase
dc.subjectPhenazine Methosulfate
dc.subjectNadph Oxidases
dc.subjectScavenging Activity
dc.subjectAntioxidant Activity
dc.subjectHydrogen-peroxide
dc.subjectOxidative Stress
dc.titleSuperoxide Anion Radical: Generation And Detection In Cellular And Non-cellular Systems
dc.typeArtículos de revistas


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