Fetal Kidney Programming By Maternal Smoking Exposure: Effects On Kidney Structure, Blood Pressure And Urinary Sodium Excretion In Adult Offspring

dc.creatorBlock
dc.creatorDaniel B.; Mesquita
dc.creatorFlavia F.; de Lima
dc.creatorIze P.; Boer
dc.creatorPatricia A.; Gontijo
dc.creatorJose A. R.
dc.date2015
dc.date2016-06-07T13:22:11Z
dc.date2016-06-07T13:22:11Z
dc.date.accessioned2018-03-29T01:41:51Z
dc.date.available2018-03-29T01:41:51Z
dc.identifier
dc.identifierFetal Kidney Programming By Maternal Smoking Exposure: Effects On Kidney Structure, Blood Pressure And Urinary Sodium Excretion In Adult Offspring. Karger, v. 129, p. 283-292 2015.
dc.identifier1660-8151
dc.identifierWOS:000353721100008
dc.identifier10.1159/000377634
dc.identifierhttps://www.karger.com/Article/Abstract/377634
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243194
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306892
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionIntroduction: Fetal programming by different insults results in low birth weight and reduction in nephron number increasing the risk for adult development of cardiovascular and renal diseases. Maternal smoking is an important modifiable adverse fetal exposure worldwide and leads to a decrease in the offspring's birth weight. Thus far, the specific adverse fetal smoking exposures and mechanisms underlying these associations on renal development and functional disorder are unclear. Methods: The present study investigates, in adult male rats, the effect of smoking exposure (Sk) in uteri on blood pressure (BP) by an indirect tail-cuff method using an electrosphygmomanometer, and its association with nephron structure by stereological estimation, immunohistochemical and histological techniques, in parallel with kidney function creatinine and lithium clearance. Results: The current study showed in a 16-week old Sk offspring enhanced arterial blood pressure associated with, reduced urinary sodium excretion and higher TGF-beta 1 glomerular expression. Sk glomeruli also presented an upregulated collagen and fibronectin deposition intrinsically related to fibrotic process as compared to age-matched control group. Conclusion: Here, we demonstrate that fetal-programmed Sk offspring present pronounced glomerular TGF-beta 1 and fibrotic marker expression that may, subsequently, promote a glomerular epithelial-mesenchymal transition activated process in an Sk offspring. Although the precise mechanism responsible for the subsequently renal morphological and functional response in Sk offspring is incompletely known, the current data suggest that changes in renal function are conducive to excess sodium tubule reabsorption that is associated with enhanced TGF-beta 1, fibronectin and collagen deposition, intrinsically related to fibrotic process, might potentiate the programming of adult hypertension. (C) 2015 S. Karger AG, Basel
dc.description129
dc.description4
dc.description
dc.description283
dc.description292
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCNPq [500868/91-3]
dc.descriptionFAPESP [10/52696-0, 11/17016-1]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherKARGER
dc.publisher
dc.publisherBASEL
dc.relationNEPHRON
dc.rightsfechado
dc.sourceWOS
dc.subjectLow-birth-weight
dc.subjectMesenchymal Transition
dc.subjectNephron Endowment
dc.subjectCigarette-smoking
dc.subjectGeneration-r
dc.subjectHypertension
dc.subjectMechanisms
dc.subjectExpression
dc.subjectDisease
dc.subjectGrowth
dc.titleFetal Kidney Programming By Maternal Smoking Exposure: Effects On Kidney Structure, Blood Pressure And Urinary Sodium Excretion In Adult Offspring
dc.typeArtículos de revistas


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