Prenatal Exposure To Testosterone Masculinises The Female Gerbil And Promotes The Development Of Lesions In The Prostate (skene's Gland)

dc.creatorBiancardi
dc.creatorManoel F.; Perez
dc.creatorAna P. S.; Suzuki Caires
dc.creatorCassia Regina; Goes
dc.creatorRejane M.; Vilamaior
dc.creatorPatricia S. L.; Santos
dc.creatorFernanda C. A.; Taboga
dc.creatorSebastiao R.
dc.date2015
dc.date2016-06-07T13:22:10Z
dc.date2016-06-07T13:22:10Z
dc.date.accessioned2018-03-29T01:41:50Z
dc.date.available2018-03-29T01:41:50Z
dc.identifier
dc.identifierPrenatal Exposure To Testosterone Masculinises The Female Gerbil And Promotes The Development Of Lesions In The Prostate (skene's Gland). Csiro Publishing, v. 27, p. 1000-1011 2015.
dc.identifier1031-3613
dc.identifierWOS:000360395200002
dc.identifier10.1071/RD13387
dc.identifierhttp://www.publish.csiro.au/?paper=RD13387
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243190
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306888
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionAndrogenic imbalance may disrupt prostate development, leading to morphological alterations in adulthood and predisposing this gland to develop diseases during ageing. However, little is known about the endocrine disruption of the prostate that is caused by androgenic compounds, especially in female experimental models. Therefore, this study aimed to evaluate the prostates of aged female gerbils exposed to testosterone at certain periods in intrauterine and postnatal life, to determine whether exposure at a particular age increases susceptibility to prostatic lesions in these animals. To this end, morphological, stereological, immunohistochemical and immunofluorescence analyses were employed. It was found that females exposed to testosterone during intrauterine life were masculinised, showing increased anogenital distance, absence of the vaginal opening and ectopic development of prostatic tissue. Several areas of adenomatous hyperplasia, generally associated with inflammatory foci and mainly located in the ectopic prostatic tissue around the vaginal wall, were also observed. In conclusion, the results showed that abnormal prenatal exposure to testosterone severely affects the reproductive systems of female animals by disrupting normal prostate morphogenesis and increasing susceptibility to the development of prostatic diseases during ageing.
dc.description27
dc.description7
dc.description
dc.description1000
dc.description1011
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2009/16789-7, 2009/53990-2]
dc.descriptionCNPq [301596/2011-5]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherCSIRO PUBLISHING
dc.publisher
dc.publisherCLAYTON
dc.relationREPRODUCTION FERTILITY AND DEVELOPMENT
dc.rightsfechado
dc.sourceWOS
dc.subjectSprague-dawley Rats
dc.subjectMeriones-unguiculatus
dc.subjectSexual Development
dc.subjectAndrogen Receptor
dc.subjectUrogenital Sinus
dc.subjectAdult Gerbils
dc.subjectGrowth
dc.subjectEthinylestradiol
dc.subjectCarcinogenesis
dc.subjectHyperplasia
dc.titlePrenatal Exposure To Testosterone Masculinises The Female Gerbil And Promotes The Development Of Lesions In The Prostate (skene's Gland)
dc.typeArtículos de revistas


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