From Conformation To Interaction: Techniques To Explore The Hsp70/hsp90 Network

dc.creatorBatista
dc.creatorFernanda A. H.; Gava
dc.creatorLisandra M.; Pinheiro
dc.creatorGlyucia M. S.; Ramos
dc.creatorCarlos H. I.; Borges
dc.creatorJulio C.
dc.date2015
dc.date2016-06-07T13:22:06Z
dc.date2016-06-07T13:22:06Z
dc.date.accessioned2018-03-29T01:41:47Z
dc.date.available2018-03-29T01:41:47Z
dc.identifier
dc.identifierFrom Conformation To Interaction: Techniques To Explore The Hsp70/hsp90 Network. Bentham Science Publ Ltd, v. 16, p. 735-753 2015.
dc.identifier1389-2037
dc.identifierWOS:000360697100007
dc.identifier10.2174/1389203716666150505225744
dc.identifierhttp://benthamscience.com/journals/current-protein-and-peptide-science/volume/16/issue/8/page/735/
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243179
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306877
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionProteins participate in almost every cell physiological function, and to do so, they need to reach a state that allows its function by folding and/or exposing surfaces of interactions. Spontaneous folding in the cell is in general hindered by its crowded and viscous environment, which favors misfolding and nonspecific and deleterious self-interactions. To overcome this, cells have a system, in which Hsp70 and Hsp90 play a central role to aid protein folding and avoid misfolding. The topics of this review include the biophysical tools used for monitoring protein-ligand and protein-protein interactions and also some important results related to the study of molecular chaperones and heat shock proteins (Hsp), with a focus on the Hsp70/Hsp90 network. The biophysical tools and their use to probe the conformation and interaction of Hsp70 and Hsp90 are briefly reviewed.
dc.description16
dc.description8
dc.description
dc.description735
dc.description753
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description
dc.description
dc.description
dc.languageen
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.publisher
dc.publisherSHARJAH
dc.relationCURRENT PROTEIN & PEPTIDE SCIENCE
dc.rightsfechado
dc.sourceWOS
dc.subjectHeat-shock-protein
dc.subjectIsothermal Titration Calorimetry
dc.subjectSize-exclusion Chromatography
dc.subjectNucleotide-induced Changes
dc.subjectHsp90 Chaperone Machinery
dc.subjectAnalytical Ultracentrifugation
dc.subjectMolecular Chaperones
dc.subjectCo-chaperone
dc.subjectLight-scattering
dc.subjectHsp70 Chaperones
dc.titleFrom Conformation To Interaction: Techniques To Explore The Hsp70/hsp90 Network
dc.typeArtículos de revistas
dc.typeResumo


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