Numerical Study Of The Impact Of The Solution Flow Rate In The Supercritical Antisolvent Process: A 3d Approach

dc.creatorAlmeida
dc.creatorRegiani A.; Rezende
dc.creatorRicardo V. P.; Guirardello
dc.creatorReginaldo; Meier
dc.creatorHenry F.; Noriler
dc.creatorDirceu; Filho
dc.creatorLucio C.; Cabral
dc.creatorVladimir F.
dc.date2015
dc.date2016-06-07T13:21:58Z
dc.date2016-06-07T13:21:58Z
dc.date.accessioned2018-03-29T01:41:40Z
dc.date.available2018-03-29T01:41:40Z
dc.identifier978-88-95608-34-1
dc.identifierNumerical Study Of The Impact Of The Solution Flow Rate In The Supercritical Antisolvent Process: A 3d Approach. Aidic Servizi Srl, v. 43, p. 1633-1638 2015.
dc.identifier1974-9791
dc.identifierWOS:000365994200273
dc.identifier10.3303/CET1543273
dc.identifierhttp://www.aidic.it/cet/index.html
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243148
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306846
dc.descriptionProcesses for precipitation of micro and nanoparticles using CO2 in supercritical state have proved to be an efficient way to process a large number of compounds from various fields, particularly in the pharmaceutical and food industry. In the face of experimental difficulties, the computer simulation appears as a useful tool to determine important parameters of the process. Using a three-dimensional mathematical model, it was studied the development of a jet of solution (ethanol and minocycline) expanded in pressurized carbon dioxide in order to interpret the process of development of regions of supersaturation of the solution. The commercial code ANSYS FLUENT was used to solve the model relating the impact of the flow of solution (1, 3 and 5 ml/min) in the mixing chamber of the precipitation process. The influence of turbulence in the flow dynamics was analyzed with the k-epsilon and k-omega models. Analysis of supersaturation profiles showed that by increasing the solution flow rate there is an increase in supersaturation and also occur more recirculation regions. So the conditions of injection of a given solution, considered in this work, determine distinct regions of nucleation and particle growth. These characteristics can be taken into account in the design of a chamber that offers conditions for the precipitation of small particle with fewer clusters.
dc.description43
dc.description
dc.description
dc.description1633
dc.description1638
dc.description
dc.description
dc.description
dc.languageen
dc.publisherAIDIC SERVIZI SRL
dc.publisher
dc.publisherMILANO
dc.relationICHEAP12: 12TH INTERNATIONAL CONFERENCE ON CHEMICAL & PROCESS ENGINEERING
dc.rightsfechado
dc.sourceWOS
dc.subjectSas Process
dc.subjectCrystallization
dc.subjectMicronization
dc.subjectPrecipitation
dc.subjectSolubility
dc.titleNumerical Study Of The Impact Of The Solution Flow Rate In The Supercritical Antisolvent Process: A 3d Approach
dc.typeActas de congresos


Este ítem pertenece a la siguiente institución