The Prognostic Value Of Histopathological Grading Systems In Oral Squamous Cell Carcinomas

dc.creatorSawazaki-Calone
dc.creatorI.; Rangel
dc.creatorA. L. C. A.; Bueno
dc.creatorA. G.; Morais
dc.creatorC. F.; Nagai
dc.creatorH. M.; Kunz
dc.creatorR. P.; Souza
dc.creatorR. L.; Rutkauskis
dc.creatorL.; Salo
dc.creatorT.; Almangush
dc.creatorA.; Coletta
dc.creatorR. D.
dc.date2015-SEP
dc.date2016-06-07T13:21:09Z
dc.date2016-06-07T13:21:09Z
dc.date.accessioned2018-03-29T01:41:03Z
dc.date.available2018-03-29T01:41:03Z
dc.identifier
dc.identifierThe Prognostic Value Of Histopathological Grading Systems In Oral Squamous Cell Carcinomas. Wiley-blackwell, v. 21, p. 755-761 SEP-2015.
dc.identifier1354-523X
dc.identifierWOS:000359345200010
dc.identifier10.1111/odi.12343
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/odi.12343/abstract
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243031
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306729
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionObjectiveThis study evaluated the association of four histopathological grading systems (WHO grading system, malignancy grading of the deep invasive margins (MG), histological risk (HR) model, and tumor budding and depth of invasion (BD) model) with clinicopathological parameters and outcome of 113 oral squamous cell carcinomas to identify their roles in prognosis. MethodsDemographic and clinical features were obtained from patients' records. Sections from all paraffin-embedded blocks were evaluated according to the four grading systems. Demographic and clinical associations were analyzed using chi-square test, and correlations between the grading systems were established with the Spearman's rank correlation test. Survival curves were performed with Kaplan-Meier method, and multivariate analysis based on Cox proportional hazard model was calculated. ResultsSignificant associations with survival were observed for WHO grading system and BD model in the univariate analysis, but only the BD model was significantly associated with disease outcome as an independent prognostic marker. Age, tumor size, and presence of regional metastasis were also independent markers of reduced survival. ConclusionA significant association between the BD model and outcome of OSCC patients was observed, indicating this new histopathological grading system as a possible prognostic tool.
dc.description21
dc.description6
dc.description
dc.description755
dc.description761
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFAPESP [2013/01607-6]
dc.descriptionCAPES [PVES 109/2012]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherWILEY-BLACKWELL
dc.publisher
dc.publisherHOBOKEN
dc.relationORAL DISEASES
dc.rightsfechado
dc.sourceWOS
dc.subjectTongue Cancer
dc.subjectTumor Thickness
dc.subjectInvasive Front
dc.subjectNeck-cancer
dc.subjectSurvival
dc.subjectCavity
dc.subjectStage
dc.subjectHead
dc.subjectMicroenvironment
dc.subjectAggressiveness
dc.titleThe Prognostic Value Of Histopathological Grading Systems In Oral Squamous Cell Carcinomas
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución