Molecular And Neuroendocrine Mechanisms Of Cancer Cachexia

dc.creatorMendes
dc.creatorMaria Carolina S.; Pimentel
dc.creatorGustavo D.; Costa
dc.creatorFelipe O.; Carvalheira
dc.creatorJose B. C.
dc.date2015-SEP
dc.date2016-06-07T13:20:55Z
dc.date2016-06-07T13:20:55Z
dc.date.accessioned2018-03-29T01:40:52Z
dc.date.available2018-03-29T01:40:52Z
dc.identifier
dc.identifierMolecular And Neuroendocrine Mechanisms Of Cancer Cachexia. Bioscientifica Ltd, v. 226, p. R29-R43 SEP-2015.
dc.identifier0022-0795
dc.identifierWOS:000360941600002
dc.identifier10.1530/JOE-15-0170
dc.identifierhttp://joe.endocrinology-journals.org/content/226/3/R29.long
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242981
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306679
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCancer and its morbidities, such as cancer cachexia, constitute a major public health problem. Although cancer cachexia has afflicted humanity for centuries, its underlying multifactorial and complex physiopathology has hindered the understanding of its mechanism. During the last few decades we have witnessed a dramatic increase in the understanding of cancer cachexia pathophysiology. Anorexia and muscle and adipose tissue wasting are the main features of cancer cachexia. These apparently independent symptoms have humoral factors secreted by the tumor as a common cause. Importantly, the hypothalamus has emerged as an organ that senses the peripheral signals emanating from the tumoral environment, and not only elicits anorexia but also contributes to the development of muscle and adipose tissue loss. Herein, we review the roles of factors secreted by the tumor and its effects on the hypothalamus, muscle and adipose tissue, as well as highlighting the key targets that are being exploited for cancer cachexia treatment.
dc.description226
dc.description3
dc.description
dc.descriptionR29
dc.descriptionR43
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundacao de Amparo a Pesquisa de Sao Paulo [2013/07607-8, 2014/22347-5]
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description
dc.description
dc.description
dc.languageen
dc.publisherBIOSCIENTIFICA LTD
dc.publisher
dc.publisherBRISTOL
dc.relationJOURNAL OF ENDOCRINOLOGY
dc.rightsfechado
dc.sourceWOS
dc.subjectTumor-bearing Rats
dc.subjectLipid-mobilizing Factor
dc.subjectSkeletal-muscle Atrophy
dc.subjectNecrosis-factor-alpha
dc.subjectBrown-adipose-tissue
dc.subjectActivated Protein-kinase
dc.subjectNf-kappa-b
dc.subjectMelanocortin-4 Receptor Antagonist
dc.subjectProteolysis-inducing Factor
dc.subjectAgouti-related Peptide
dc.titleMolecular And Neuroendocrine Mechanisms Of Cancer Cachexia
dc.typeArtículos de revistas
dc.typeResumo


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