Antimicrobial And Cytotoxic Activity Of Red Propolis: An Alert For Its Safe Use

dc.creatorLopez
dc.creatorB. G. C.; de Lourenco
dc.creatorC. C.; Alves
dc.creatorD. A.; Machado
dc.creatorD.; Lancellotti
dc.creatorM.; Sawaya
dc.creatorA. C. H. F.
dc.date2015-SEP
dc.date2016-06-07T13:20:52Z
dc.date2016-06-07T13:20:52Z
dc.date.accessioned2018-03-29T01:40:49Z
dc.date.available2018-03-29T01:40:49Z
dc.identifier
dc.identifierAntimicrobial And Cytotoxic Activity Of Red Propolis: An Alert For Its Safe Use. Wiley-blackwell, v. 119, p. 677-687 SEP-2015.
dc.identifier1364-5072
dc.identifierWOS:000360231000007
dc.identifier10.1111/jam.12874
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/jam.12874/abstract
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242969
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306667
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionAimsRed propolis is a resinous product popularly consumed in Brazil as it improves health, and it is considered a nutraceutical. The objective of this study was to test the antimicrobial activity of eight samples of red propolis from Brazil and Cuba to assess the possibility of application of this natural product as an antimicrobial agent, along with a study of its cytotoxic activity against non-tumor cell lines to evaluate at which concentrations it could be safely used. Methods and ResultsThe chemical profile of the samples was evaluated by UHPLC-MS. All the samples presented antimicrobial activity which was tested using agar diffusion and serial dilution methods; and these samples displayed a better activity against most Gram-negative bacteria with minimum inhibitory concentration (MIC) in the range between 625gml(-1) and 500gml(-1). However our studies also revealed an inherent cytotoxic effect against HaCaT human keratinocytes and BALBc 3T3. ConclusionsTo have a noncytotoxic and safe use of red propolis, it is necessary to use a concentration below the IC50 cytotoxic values. Significance and Impact of the StudyThe traditional use of propolis does not necessarily guarantee its safety. The evaluation of the safety of bioactive natural products should always be considered together with the evaluation of the activity.
dc.description119
dc.description3
dc.description
dc.description677
dc.description687
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFAPESP [2013-20313-3]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherWILEY-BLACKWELL
dc.publisher
dc.publisherHOBOKEN
dc.relationJOURNAL OF APPLIED MICROBIOLOGY
dc.rightsfechado
dc.sourceWOS
dc.subjectStaphylococcus-aureus Infections
dc.subjectBrazilian Propolis
dc.subjectEnterococcus-faecalis
dc.subjectNatural-products
dc.subjectChemical-composition
dc.subjectEndothelial-cells
dc.subjectEscherichia-coli
dc.subjectBotanical Origin
dc.subjectDrug Discovery
dc.subjectBee Products
dc.titleAntimicrobial And Cytotoxic Activity Of Red Propolis: An Alert For Its Safe Use
dc.typeArtículos de revistas


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