Dysregulation Of The Rb Pathway In Recurrent Pleomorphic Adenoma Of The Salivary Glands

dc.creatorde Souza
dc.creatorAna Amelia; Altemani
dc.creatorAlbina; Passador-Santos
dc.creatorFabricio; Turssi
dc.creatorCecilia Pedroso; de Araujo
dc.creatorNey Soares; de Araujo
dc.creatorVera Cavalcanti; Soares
dc.creatorAndresa Borges
dc.date2015-SEP
dc.date2016-06-07T13:20:43Z
dc.date2016-06-07T13:20:43Z
dc.date.accessioned2018-03-29T01:40:41Z
dc.date.available2018-03-29T01:40:41Z
dc.identifier
dc.identifierDysregulation Of The Rb Pathway In Recurrent Pleomorphic Adenoma Of The Salivary Glands. Springer, v. 467, p. 295-301 SEP-2015.
dc.identifier0945-6317
dc.identifierWOS:000360508900007
dc.identifier10.1007/s00428-015-1804-x
dc.identifierhttp://link.springer.com/article/10.1007%2Fs00428-015-1804-x
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242936
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306634
dc.descriptionPleomorphic adenoma (PA) is the most common salivary gland neoplasm, and while mostly benign, recurrences (RPA) and malignant transformation to carcinoma ex-PA (CXPA) do occur. Cell cycle proteins important in its tumorigenesis have been studied as markers for PA with a high risk of RPA or CXPA. The aim of the present study was to investigate cell cycle markers p-16, cyclin D1, CDK4, E2F, and retinoblastoma (Rb) in this context. Expression of p16, cyclin D1, E2F, CDK4, and Rb was studied by immunohistochemistry in 24 cases of PA, 21 of RPA, and 2 of CXPA. The presence of HPV was assessed by in situ hybridization. Immunostaining for p16 and cyclin D1 was negative or weakly positive in most cases of PA while strongly positive in the majority of RPA and both CXPA cases. Staining for Rb and CDK4 was either negative or weakly positive in PA, RPA, and CXPA. Expression of E2F was stronger in RPA and CXPA than in PA. Nuclear reactivity for HPV was not observed in any case. In conclusion, the strong staining for p16, cyclinD1, and E2F in RPA and CXPA, while weak or negative in PA, suggests that these proteins might be involved in recurrence and malignant transformation of PA.
dc.description467
dc.description3
dc.description
dc.description295
dc.description301
dc.description
dc.description
dc.description
dc.languageen
dc.publisherSPRINGER
dc.publisher
dc.publisherNEW YORK
dc.relationVIRCHOWS ARCHIV
dc.rightsfechado
dc.sourceWOS
dc.subjectSquamous-cell Carcinoma
dc.subjectCyclin D1 Expression
dc.subjectCystic Carcinoma
dc.subjectAbnormal Expression
dc.subjectImmunohistochemical Expression
dc.subjectMalignant-transformation
dc.subjectPromoter Methylation
dc.subjectProtein Expression
dc.subjectTumor Progression
dc.subjectP16 Expression
dc.titleDysregulation Of The Rb Pathway In Recurrent Pleomorphic Adenoma Of The Salivary Glands
dc.typeArtículos de revistas


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