The Network Organization Of Protein Interactions In The Spliceosome Is Reproduced By The Simple Rules Of Food-web Models

dc.creatorPires
dc.creatorMathias M.; Cantor
dc.creatorMauricio; Guimaraes
dc.creatorPaulo R.; de Aguiar
dc.creatorMarcus A. M.; dos Reis
dc.creatorSergio F.; Coltri
dc.creatorPatricia P.
dc.date2015-OCT
dc.date2016-06-07T13:20:24Z
dc.date2016-06-07T13:20:24Z
dc.date.accessioned2018-03-29T01:40:26Z
dc.date.available2018-03-29T01:40:26Z
dc.identifier
dc.identifierThe Network Organization Of Protein Interactions In The Spliceosome Is Reproduced By The Simple Rules Of Food-web Models. Nature Publishing Group, v. 5, p. OCT-2015.
dc.identifier2045-2322
dc.identifierWOS:000362335400001
dc.identifier10.1038/srep14865
dc.identifierhttp://www.nature.com/articles/srep14865
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242878
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306576
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe network structure of biological systems provides information on the underlying processes shaping their organization and dynamics. Here we examined the structure of the network depicting protein interactions within the spliceosome, the macromolecular complex responsible for splicing in eukaryotic cells. We show the interactions of less connected spliceosome proteins are nested subsets of the connections of the highly connected proteins. At the same time, the network has a modular structure with groups of proteins sharing similar interaction patterns. We then investigated the role of affinity and specificity in shaping the spliceosome network by adapting a probabilistic model originally designed to reproduce food webs. This food-web model was as successful in reproducing the structure of protein interactions as it is in reproducing interactions among species. The good performance of the model suggests affinity and specificity, partially determined by protein size and the timing of association to the complex, may be determining network structure. Moreover, because network models allow building ensembles of realistic networks while encompassing uncertainty they can be useful to examine the dynamics and vulnerability of intracelullar processes. Unraveling the mechanisms organizing the spliceosome interactions is important to characterize the role of individual proteins on splicing catalysis and regulation.
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dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionKillam Trusts
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2009/54567-6, 2009/54422-8, 2013/02738-7]
dc.descriptionCNPq [202581/2011-0]
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dc.languageen
dc.publisherNATURE PUBLISHING GROUP
dc.publisher
dc.publisherLONDON
dc.relationSCIENTIFIC REPORTS
dc.rightsaberto
dc.sourceWOS
dc.subjectEcological Networks
dc.subjectPollination Networks
dc.subjectMutualistic Networks
dc.subjectMetabolic Networks
dc.subjectComplex Networks
dc.subjectRna
dc.subjectModularity
dc.subjectYeast
dc.subjectStep
dc.subjectSpecialization
dc.titleThe Network Organization Of Protein Interactions In The Spliceosome Is Reproduced By The Simple Rules Of Food-web Models
dc.typeArtículos de revistas


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