Accuracy Of Frozen Section, Imprint Cytology, And Permanent Histology Of Sub-nipple Tissue For Predicting Occult Nipple Involvement In Patients With Breast Carcinoma

dc.creatorDuarte
dc.creatorGiuliano M.; Tomazini
dc.creatorMaria Virginia; Oliveira
dc.creatorAndre; Moreira
dc.creatorLuciana; Tocchet
dc.creatorFernando; Worschech
dc.creatorAdriana; Torresan
dc.creatorRenato Z.
dc.date2015-OCT
dc.date2016-06-07T13:19:30Z
dc.date2016-06-07T13:19:30Z
dc.date.accessioned2018-03-29T01:39:41Z
dc.date.available2018-03-29T01:39:41Z
dc.identifier
dc.identifierAccuracy Of Frozen Section, Imprint Cytology, And Permanent Histology Of Sub-nipple Tissue For Predicting Occult Nipple Involvement In Patients With Breast Carcinoma. Springer, v. 153, p. 557-563 OCT-2015.
dc.identifier0167-6806
dc.identifierWOS:000361987300008
dc.identifier10.1007/s10549-015-3568-z
dc.identifierhttp://link.springer.com/article/10.1007%2Fs10549-015-3568-z
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242703
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306401
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe sub-nipple tissue (SNT) examination has been used by surgeons to preserve, or not, the nipple in nipple-sparing mastectomy. However, it is uncertain whether SNT evaluation can predict nipple involvement. The aim of this study was to evaluate the accuracy, sensitivity, specificity, PPV, and NPV of the intraoperative frozen section and imprint cytology, and permanent histology of SNT to predict the involvement of the nipple in breast carcinoma and to compare the three exams. A prospective study was performed with 68 consecutive breast carcinoma women who had undergone mastectomy or central segmentectomy (removing nipple-areolar complex). After surgery, the nipple-areolar complex was dissected simulating a nipple-sparing flap (ex vivo). The SNT was subsequently removed and submitted to frozen section, imprint cytology, and permanent histology. The nipple was examined separately by paraffin histopathology and was considered the gold standard. The occult nipple involvement rate was 11.7 %. The frozen section, cytology, and permanent histology of SNT presented accuracy 86.8, 76.5, and 86.8 %; sensitivity 50, 37.5, and 62.5 %; specificity 91.7, 81.7, and 90 %; PPV 44.4, 21.4, and 45.5 %; and NPV 93.2, 90.7, and 94.7 %, respectively. The accuracy of the frozen section was similar to that of permanent histology (p = 0.77) and both were better than cytology (p = 0.01). False negative rates were 6.8 % for frozen section, 9.3 % for cytology and 5.3 % for paraffin. SNT evaluation is a good method for predicting occult nipple involvement; the outcomes showed a good accuracy and low false negative rate for the frozen section, cytology, and permanent histology exams. When we compared the exams, the frozen section was similar to permanent histology and more accurate than imprint cytology.
dc.description153
dc.description3
dc.description
dc.description557
dc.description563
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2013/03019-4]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherSPRINGER
dc.publisher
dc.publisherNEW YORK
dc.relationBREAST CANCER RESEARCH AND TREATMENT
dc.rightsfechado
dc.sourceWOS
dc.subjectSparing Mastectomy
dc.subjectAreolar Complex
dc.subjectCancer
dc.subjectReconstruction
dc.subjectExperience
dc.subjectManagement
dc.subjectSpecimens
dc.titleAccuracy Of Frozen Section, Imprint Cytology, And Permanent Histology Of Sub-nipple Tissue For Predicting Occult Nipple Involvement In Patients With Breast Carcinoma
dc.typeArtículos de revistas


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