Effect Of Human Adipose Tissue Mesenchymal Stem Cells On The Regeneration Of Ovine Articular Cartilage

dc.creatorZorzi
dc.creatorAlessandro R.; Amstalden
dc.creatorEliane M. I.; Plepis
dc.creatorAna Maria G.; Martins
dc.creatorVirginia C. A.; Ferretti
dc.creatorMario; Antonioli
dc.creatorEliane; Duarte
dc.creatorAdriana S. S.; Luzo
dc.creatorAngela C. M.; Miranda
dc.creatorJoao B.
dc.date2015-NOV
dc.date2016-06-07T13:19:07Z
dc.date2016-06-07T13:19:07Z
dc.date.accessioned2018-03-29T01:39:21Z
dc.date.available2018-03-29T01:39:21Z
dc.identifier
dc.identifierEffect Of Human Adipose Tissue Mesenchymal Stem Cells On The Regeneration Of Ovine Articular Cartilage. Mdpi Ag, v. 16, p. 26813-26831 NOV-2015.
dc.identifier1422-0067
dc.identifierWOS:000365648300058
dc.identifier10.3390/ijms161125989
dc.identifierhttp://www.mdpi.com/1422-0067/16/11/25989
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242627
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306325
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCell therapy is a promising approach to improve cartilage healing. Adipose tissue is an abundant and readily accessible cell source. Previous studies have demonstrated good cartilage repair results with adipose tissue mesenchymal stem cells in small animal experiments. This study aimed to examine these cells in a large animal model. Thirty knees of adult sheep were randomly allocated to three treatment groups: CELLS (scaffold seeded with human adipose tissue mesenchymal stem cells), SCAFFOLD (scaffold without cells), or EMPTY (untreated lesions). A partial thickness defect was created in the medial femoral condyle. After six months, the knees were examined according to an adaptation of the International Cartilage Repair Society (ICRS 1) score, in addition to a new Partial Thickness Model scale and the ICRS macroscopic score. All of the animals completed the follow-up period. The CELLS group presented with the highest ICRS 1 score (8.3 +/- 3.1), followed by the SCAFFOLD group (5.6 +/- 2.2) and the EMPTY group (5.2 +/- 2.4) (p = 0.033). Other scores were not significantly different. These results suggest that human adipose tissue mesenchymal stem cells promoted satisfactory cartilage repair in the ovine model.
dc.description16
dc.description11
dc.description
dc.description26813
dc.description26831
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2011/17596-8]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherMDPI AG
dc.publisher
dc.publisherBASEL
dc.relationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
dc.rightsaberto
dc.sourceWOS
dc.subjectRepair-society Icrs
dc.subjectFollow-up
dc.subjectSubchondral Bone
dc.subjectDefects
dc.subjectModel
dc.subjectKnee
dc.subjectImplantation
dc.subjectChondrocytes
dc.subjectScaffolds
dc.subjectChondrogenesis
dc.titleEffect Of Human Adipose Tissue Mesenchymal Stem Cells On The Regeneration Of Ovine Articular Cartilage
dc.typeArtículos de revistas


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