Ventilatory Abnormalities In Patients With Cystic Fibrosis Undergoing The Submaximal Treadmill Exercise Test

dc.creatorFrancisco Parazzi
dc.creatorPaloma Lopes; de Lima Marson
dc.creatorFernando Augusto; Goncalves de Oliveira Ribeiro
dc.creatorMaria Angela; Bresciani de Almeida
dc.creatorCelize Cruz; Martins
dc.creatorLuiz Claudio; Paschoal
dc.creatorIlma Aparecida; Dalbo Contrera Toro
dc.creatorAdyleia Aparecida; Santos Schivinski
dc.creatorCamila Isabel; Ribeiro
dc.creatorJose Dirceu
dc.date2015-MAY
dc.date2016-06-07T13:17:53Z
dc.date2016-06-07T13:17:53Z
dc.date.accessioned2018-03-29T01:38:25Z
dc.date.available2018-03-29T01:38:25Z
dc.identifier
dc.identifierVentilatory Abnormalities In Patients With Cystic Fibrosis Undergoing The Submaximal Treadmill Exercise Test. Biomed Central Ltd, v. 15, p. MAY-2015.
dc.identifier1471-2466
dc.identifierWOS:000355164800001
dc.identifier10.1186/s12890-015-0056-5
dc.identifierhttp://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-015-0056-5
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242428
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306126
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground: Exercise has been studied as a prognostic marker for patients with cystic fibrosis (CF), as well as a tool for improving their quality of life and analyzing lung disease. In this context, the aim of the present study was to evaluate and compare variables of lung functioning. Our data included: (i) volumetric capnography (VCAP) parameters: expiratory minute volume (VE), volume of exhaled carbon dioxide (VCO2), VE/VCO2, ratio of dead space to tidal volume (VD/VT), and end-tidal carbon dioxide (PetCO(2)); (ii) spirometry parameters: forced vital capacity (FVC), percent forced expiratory volume in the first second of the FVC (FEV1%), and FEV1/FVC%; and (iii) cardiorespiratory parameters: heart rate (HR), respiratory rate, oxygen saturation (SpO(2)), and Borg scale rating at rest and during exercise. The subjects comprised children, adolescents, and young adults aged 6-25 years with CF (CF group [CFG]) and without CF (control group [CG]). Methods: This was a clinical, prospective, controlled study involving 128 male and female patients (64 with CF) of a university hospital. All patients underwent treadmill exercise tests and provided informed consent after study approval by the institutional ethics committee. Linear regression, Kruskal-Wallis test, and Mann-Whitney test were performed to compare the CFG and CG. The a value was set at 0.05. Results: Patients in the CFG showed significantly different VCAP values and spirometry variables throughout the exercise test. Before, during, and after exercise, several variables were different between the two groups; statistically significant differences were seen in the spirometry parameters, SpO(2), HR, VCO2, VE/VCO2, PetCO2, and Borg scale rating. VCAP variables changed at each time point analyzed during the exercise test in both groups. Conclusion: VCAP can be used to analyze ventilatory parameters during exercise. All cardiorespiratory, spirometry, and VCAP variables differed between patients in the CFG and CG before, during, and after exercise.
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dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2011/12939-4]
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dc.languageen
dc.publisherBIOMED CENTRAL LTD
dc.publisher
dc.publisherLONDON
dc.relationBMC PULMONARY MEDICINE
dc.rightsaberto
dc.sourceWOS
dc.subject6-minute Walk Test
dc.subjectFlow Limitation
dc.subjectDisease
dc.subjectStatement
dc.subjectChildren
dc.subjectOutcomes
dc.subjectCurves
dc.subjectYoung
dc.subjectTool
dc.titleVentilatory Abnormalities In Patients With Cystic Fibrosis Undergoing The Submaximal Treadmill Exercise Test
dc.typeArtículos de revistas


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