Blood Metabolome Changes Before And After Bariatric Surgery: A H-1 Nmr-based Clinical Investigation

dc.creatorLopes
dc.creatorThiago I. B.; Geloneze
dc.creatorBruno; Pareja
dc.creatorJose C.; Calixto
dc.creatorAntonio R.; Ferreira
dc.creatorMarcia M. C.; Marsaioli
dc.creatorAnita J.
dc.date2015-MAY
dc.date2016-06-07T13:17:47Z
dc.date2016-06-07T13:17:47Z
dc.date.accessioned2018-03-29T01:38:19Z
dc.date.available2018-03-29T01:38:19Z
dc.identifier
dc.identifierBlood Metabolome Changes Before And After Bariatric Surgery: A H-1 Nmr-based Clinical Investigation. Mary Ann Liebert, Inc, v. 19, p. 318-327 MAY-2015.
dc.identifier1536-2310
dc.identifierWOS:000353693100006
dc.identifier10.1089/omi.2015.0009
dc.identifierhttp://online.liebertpub.com/doi/abs/10.1089/omi.2015.0009
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242406
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306104
dc.descriptionExcessive body fat and obesity have adverse health effects and result in significant morbidity such as type 2 diabetes mellitus. The health burden of obesity can be reduced with the Roux-en-Y gastric bypass (RYGB) weight-loss bariatric surgery. Little is known on the molecular changes that occur at the metabolome level before and after bariatric surgery, with a view to clinical biomarker development. Hence, we employed a metabolomics approach in 10 obese diabetic patients who underwent bariatric surgery. Metabolomics data were obtained by T-2- and diffusion-edited hydrogen nuclear magnetic resonance (H-1 NMR) spectra to monitor the metabolic and lipoprotein profiles, and gas chromatography-mass spectrometry (CG-MS) to access the fatty acid profile before and 12 months after RYGB. Using hierarchical partial least squares discriminant analysis, we found that RYGB induces several key metabolic alterations associated with glucose homeostasis, as well as fatty acid and amino acid metabolism. The levels of lactate (Krebs' intermediate cycle) decreased after RYGB. The leucine, isoleucine, valine, lactate, and glucose levels were higher in the samples before RYGB (p<0.05). Additionally, the levels of very low-density lipoprotein, unsaturated lipids, and N-acetyl-glycoprotein were higher before RYGB. By contrast, levels of the high-density lipoprotein and phosphatidylcholine were higher after bariatric surgery. These results collectively offer important holistic integrative biology data to develop future clinically relevant metabolomics biomarkers related to bariatric surgery in connection with obesity.
dc.description19
dc.description5
dc.description
dc.description318
dc.description327
dc.description
dc.description
dc.description
dc.languageen
dc.publisherMARY ANN LIEBERT, INC
dc.publisher
dc.publisherNEW ROCHELLE
dc.relationOMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
dc.rightsembargo
dc.sourceWOS
dc.subjectGastric Bypass-surgery
dc.subjectH-1-nmr Spectroscopy
dc.subjectAmino-acids
dc.subjectPlasma
dc.subjectLipoproteins
dc.subjectObese
dc.subjectGlucose
dc.subjectWeight
dc.subjectImpact
dc.subjectDiet
dc.titleBlood Metabolome Changes Before And After Bariatric Surgery: A H-1 Nmr-based Clinical Investigation
dc.typeArtículos de revistas


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