Recovery Of The Incretin Effect In Type 2 Diabetic Patients After Biliopancreatic Diversion

dc.creatorNovaes
dc.creatorFernanda S.; Vasques
dc.creatorAna C. J.; Pareja
dc.creatorJose C.; Knop
dc.creatorFilip K.; Tura
dc.creatorAndrea; Chaim
dc.creatorElinton A.; Geloneze
dc.creatorBruno
dc.date2015-MAY
dc.date2016-06-07T13:17:37Z
dc.date2016-06-07T13:17:37Z
dc.date.accessioned2018-03-29T01:38:10Z
dc.date.available2018-03-29T01:38:10Z
dc.identifier
dc.identifierRecovery Of The Incretin Effect In Type 2 Diabetic Patients After Biliopancreatic Diversion. Endocrine Soc, v. 100, p. 1984-1988 MAY-2015.
dc.identifier0021-972X
dc.identifierWOS:000357669000053
dc.identifier10.1210/jc.2014-4042
dc.identifierhttp://press.endocrine.org/doi/10.1210/jc.2014-4042
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242366
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1306064
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionContext: Bariatric surgery often results in remission of the diabetic state in obese patients. Increased incretin effect seems to play an important role in the glycemic improvements after Rouxen-Y gastric bypass, but the impact of biliopancreatic diversion (BPD) remains unexplored. Objective: The objective was to elucidate the effect of BPD on the incretin effect and its interplay with beta-cell function and insulin sensitivity (IS) in obese subjects with type 2 diabetes (T2DM). Design, Setting and Patients: Twenty-three women were studied: a control group of 13 lean, normal glucose-tolerant women (lean NGT) studied once and 10 obese patients with T2DM studied before, 1 and 12 months after BPD. Intervention: The ObeseT2DM group underwent BPD. Main Outcome Measures: The main outcome measure was the change in incretin effect as measured by the isoglycemic intravenous glucose infusion test. Secondary outcomes encompassed IS and beta-cell function. Results: At baseline, the incretin effect was lower in obese T2DM compared to lean NGT (P < .05). One month after BPD, the incretin effect was not changed, but at 12 months it reached the level of the lean NGT group (P < .05). IS improved (P < .05) 1 month after BPD and at 12 months it resembled the levels of the lean NGT group. Insulin secretory rate and beta-cell glucose sensitivity increased after BPD and achieved levels similar to lean NGT group 1 month after BPD and even higher levels at 12 months (P < .05). Conclusions: BPD has no acute impact on the reduced incretin effect, but 12 months after surgery the incretin effect normalizes alongside normalization of glucose control, IS and beta-cell function.
dc.description100
dc.description5
dc.description
dc.description1984
dc.description1988
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2008/07312-0]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherENDOCRINE SOC
dc.publisher
dc.publisherWASHINGTON
dc.relationJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
dc.rightsfechado
dc.sourceWOS
dc.subjectGastric Bypass-surgery
dc.subjectBeta-cell Function
dc.subjectBariatric Surgery
dc.subjectGlucose-tolerance
dc.subjectObese-patients
dc.subjectWeight-loss
dc.subjectRestoration
dc.subjectMechanisms
dc.subjectMellitus
dc.subjectGlucagon
dc.titleRecovery Of The Incretin Effect In Type 2 Diabetic Patients After Biliopancreatic Diversion
dc.typeArtículos de revistas


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