Tissue Content Of Sulfomucins And Sialomucins In The Colonic Mucosa, Without Fecal Stream, Undergoing Daily Intervention With Sucralfate

dc.creatorGabriel Bonassa
dc.creatorChristiny Emmanuelle; Pereira
dc.creatorJose Aires; Caserta Maryssael de Campos
dc.creatorFabio Guilherme; Rodrigues
dc.creatorMurilo Rocha; Sato
dc.creatorDaniela Tiemi; Mendonca Chaim
dc.creatorFelipe David; Real Martinez
dc.creatorCarlos Augusto
dc.date2015-MAY
dc.date2016-06-07T13:17:18Z
dc.date2016-06-07T13:17:18Z
dc.date.accessioned2018-03-29T01:37:51Z
dc.date.available2018-03-29T01:37:51Z
dc.identifier
dc.identifierTissue Content Of Sulfomucins And Sialomucins In The Colonic Mucosa, Without Fecal Stream, Undergoing Daily Intervention With Sucralfate. Acta Cirurgica Brasileira, v. 30, p. 328-338 MAY-2015.
dc.identifier0102-8650
dc.identifierWOS:000355312700004
dc.identifier10.1590/S0102-865020150050000004
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000500328&lng=en&nrm=iso&tlng=en
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242288
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305986
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionPURPOSE: To measure the content of acidic mucin, sialomucin, and sulfomucins in the colonic mucosa without fecal stream submit to intervention with sucralfate (SCF). METHODS: Thirty-six rats were submitted to a right colostomy and a distal mucous fistula and divided into two groups according to sacrifice to be performed two or four weeks. Each group was divided into three subgroups according daily application of enemas containing saline, SCF at 1.0 g/kg/day or 2.0 g/kg/day. Colitis was diagnosed by histological analysis. Acid mucins were determined with the Alcian-Blue and sulfomucin and sialomucin by high iron diamine-alcian blue (HID-AB) techniques. The mucins were quantified by computer-assisted image analysis. Mann-Whitney and ANOVA tests were used to analyze the results establishing the level of significance of 5% for both (p<0.05). RESULTS: SCF enemas decreased the inflammation score and was related to the concentration used and time of the intervention. SCF at both concentrations increased the content of acid mucin, which was related to the concentration used and to the improvement in the inflammatory score. There was an increase in the content of sulfomucins and sialomucins in SCF groups. SCF increased sulfomucins from 2 weeks of intervention, which was not related to the dose or time of application. The increase in sialomucin content was related to the time and dose used in the intervention. CONCLUSION: Sucralfate increased the content of acidic mucins, primarily at the expense of sialomucin, which was affected by the dose and time of intervention.
dc.description30
dc.description5
dc.description
dc.description328
dc.description338
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2010/12492-7]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherACTA CIRURGICA BRASILEIRA
dc.publisher
dc.publisherSAO PAULO
dc.relationACTA CIRURGICA BRASILEIRA
dc.rightsfechado
dc.sourceWOS
dc.subjectDiversion Colitis
dc.subjectUlcerative-colitis
dc.subjectEpithelial-cells
dc.subjectSodium-butyrate
dc.subjectGrowth-factor
dc.subjectGoblet Cells
dc.subjectRats
dc.subjectMucus
dc.subjectProtection
dc.subjectIschemia
dc.titleTissue Content Of Sulfomucins And Sialomucins In The Colonic Mucosa, Without Fecal Stream, Undergoing Daily Intervention With Sucralfate
dc.typeArtículos de revistas


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