Unraveling Brazilian Indian Population Prostate Good Health: Clinical, Anthropometric And Genetic Features

dc.creatorde Lima Junior
dc.creatorMario M.; Reis
dc.creatorLeonardo O.; Ferreira
dc.creatorUbirajara; Cardoso
dc.creatorUlieme Oliveira; Barbieri
dc.creatorRaquel Bueno; de Mendonca
dc.creatorGustavo B.; Ward
dc.creatorLaura S.
dc.date2015-MAR-APR
dc.date2016-06-07T13:17:10Z
dc.date2016-06-07T13:17:10Z
dc.date.accessioned2018-03-29T01:37:46Z
dc.date.available2018-03-29T01:37:46Z
dc.identifier
dc.identifierUnraveling Brazilian Indian Population Prostate Good Health: Clinical, Anthropometric And Genetic Features. Brazilian Soc Urol, v. 41, p. 344-352 MAR-APR-2015.
dc.identifier1677-5538
dc.identifierWOS:000354634500023
dc.identifier10.1590/S1677-5538.IBJU.2015.02.23
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000200344&lng=en&nrm=iso&tlng=en
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242265
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305963
dc.descriptionPurpose: To compare dietary, lifestyle, clinical, anthropometric, genetic and prostatic features of Brazilian Indians and non-Indians (Amazon). Methods: 315 men, 228 Indians and 89 non-Indians, >= 40 years old were submitted to digital rectal examination, serum prostate specific antigen (PSA), testosterone, TP53 and GSTP1 genotyping, anthropometric, lifestyle, dietary, personal and familial medical history. Prostatic symptoms were evaluated with the International Prostate Symptom Score (IPSS). Results: Macuxis and Yanomamis represented 43.6% and 14.5% of Indians respectively who spontaneously referred no prostate symptoms. Mean IPSS was 7, range 3-19, with only 15% of moderate symptoms (score 8-19); Mean age was 54.7 years, waist circumference 86.6 cm, BMI 23.9 kg/m(2). Yanomamis presented both lower BMI (21.4 versus 24.8 and 23.3, p= 0,001) and prostate volume than Macuxis and "other ethnic groups" (15 versus 20, p= 0.001). Testosterone (414 versus 502 and 512, p= 0.207) and PSA (0.48 versus 0.6 and 0.41, p= 0.349) were similar with progressive PSA increase with aging. Val/Val correlated with lower PSA (p= 0.0361). Indians compared to control population presented: -TP53 super representation of Arg/ Arg haplotype, 74.5% versus 42.5%, p< 0.0001. - GSTP1 Ile/Ile 35.3% versus 60.9%; Ile/ Val 45.9% versus 28.7%; Val/Val 18.8% versus 10.3%; p= 0.0003. Conclusions: Observed specific dietary, lifestyle, anthropometric and genetic profile for TP53 and GSTP1 may contribute to Brazilian Indian population prostate good health.
dc.description41
dc.description2
dc.description
dc.description344
dc.description352
dc.description
dc.description
dc.description
dc.languageen
dc.publisherBRAZILIAN SOC UROL
dc.publisher
dc.publisherRIO DE JANEIRO
dc.relationINTERNATIONAL BRAZ J UROL
dc.rightsfechado
dc.sourceWOS
dc.subjectCodon-72 Polymorphism
dc.subjectAmerican-indians
dc.subjectCancer Incidence
dc.subjectUnited-states
dc.subjectNew-mexico
dc.subjectBody-size
dc.subjectAntigen
dc.subjectRisk
dc.subjectMen
dc.subjectP53
dc.titleUnraveling Brazilian Indian Population Prostate Good Health: Clinical, Anthropometric And Genetic Features
dc.typeArtículos de revistas


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