Monitoring Of Multiple Solid-state Transformations At Tablet Surfaces Using Multi-series Near-infrared Hyperspectral Imaging And Multivariate Curve Resolution

dc.creatorAlexandrino
dc.creatorGuilherme L.; Khorasani
dc.creatorMilad R.; Amigo
dc.creatorJose M.; Rantanen
dc.creatorJukka; Poppi
dc.creatorRonei J.
dc.date2015-JUN
dc.date2016-06-07T13:15:59Z
dc.date2016-06-07T13:15:59Z
dc.date.accessioned2018-03-29T01:36:35Z
dc.date.available2018-03-29T01:36:35Z
dc.identifier
dc.identifierMonitoring Of Multiple Solid-state Transformations At Tablet Surfaces Using Multi-series Near-infrared Hyperspectral Imaging And Multivariate Curve Resolution. Elsevier Science Bv, v. 93, p. 224-230 JUN-2015.
dc.identifier0939-6411
dc.identifierWOS:000356554000022
dc.identifier10.1016/j.ejpb.2015.03.034
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0939641115001745
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241969
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305667
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionThe assessment of the solid-state stability of active pharmaceutical ingredient (API) and/or excipients in solid dosage forms during manufacturing and storage is mandatory for safeguarding quality of the final products. In this work, the solid-state transformations in tablets prepared as blends of piroxicam monohydrate, polyvinylpyrrolidone and the lactose forms monohydrate or anhydrate were studied when the tablets were exposed to the 23-120 degrees C range. Multi-series near-infrared hyperspectral images were obtained from the surface of each sample for unveiling the local evolution of the solid-state transformations. The preprocessed spectra from the images (dataset) were arranged in augmented matrices, according to the composition of the tablets, and the profile of the overlapped compounds (relative concentration) along the solid-state transformations in the pixels was resolved by using multivariate curve resolution alternating least squares (MCR-ALS). Therefore, the dehydration of piroxicam and lactose monohydrates could be mapped separately in the samples (explained variances by the models >96%) even when both compounds were being transformed simultaneously (80-120 degrees C). The images reproduced the same trends obtained from thermogravimetric analysis of the tablets, with the advantage that the pixel-to-pixel heterogeneity of each compound at the surface of the tablets was highlighted. (C) 2015 Elsevier B.V. All rights reserved.
dc.description93
dc.description
dc.description
dc.description224
dc.description230
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description
dc.description
dc.description
dc.languageen
dc.publisherELSEVIER SCIENCE BV
dc.publisher
dc.publisherAMSTERDAM
dc.relationEUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
dc.rightsembargo
dc.sourceWOS
dc.subjectDehydration Kinetics
dc.subjectPharmaceutical Tablets
dc.subjectNir
dc.subjectQuantification
dc.subjectDrug
dc.subjectMonohydrate
dc.subjectPolymorphs
dc.subjectDihydrate
dc.subjectPiroxicam
dc.subjectBioavailability
dc.titleMonitoring Of Multiple Solid-state Transformations At Tablet Surfaces Using Multi-series Near-infrared Hyperspectral Imaging And Multivariate Curve Resolution
dc.typeArtículos de revistas


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