In-vitro Antiviral Activities Of Extracts Of Plants Of The Brazilian Cerrado Against The Avian Metapneumovirus (ampv)

dc.creatorKohn
dc.creatorL. K.; Foglio
dc.creatorM. A.; Rodrigues
dc.creatorR. A.; Sousa
dc.creatorI. M. de O.; Martini
dc.creatorM. C.; Padilla
dc.creatorM. A.; de Lima Neto
dc.creatorD. F.; Arns
dc.creatorC. W.
dc.date2015-JUL-SEP
dc.date2016-06-07T13:15:45Z
dc.date2016-06-07T13:15:45Z
dc.date.accessioned2018-03-29T01:36:27Z
dc.date.available2018-03-29T01:36:27Z
dc.identifier
dc.identifierIn-vitro Antiviral Activities Of Extracts Of Plants Of The Brazilian Cerrado Against The Avian Metapneumovirus (ampv). Facta-fundacio Arnco Ciencia Tecnologia Avicolas, v. 17, p. 275-280 JUL-SEP-2015.
dc.identifier1516-635X
dc.identifierWOS:000362366500002
dc.identifier10.1590/1516-635x1703275-280
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2015000300275&lng=en&nrm=iso&tlng=en
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241950
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305648
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionAvian metapneumovirus (aMPV) is a negative-sense single-stranded RNA enveloped virus of the Metapneumovirus genus belonging to the Paramyxoviridae family. This virus may cause significant economic losses to the poultry industry, despite vaccination, which is the main tool for controlling and preventing aMPV. The aim of this study was to evaluate the antiviral activity of extracts of four different native plants of the Brazilian Cerrado against aMPV. The antiviral activity against aMPV was determined by titration. This technique measures the ability of plant extract dilutions (25 to 2.5 mu g mL(-1)) to inhibit the cytopathic effect (CPE) of the virus, expressed as inhibition percentage (IP). The maximum nontoxic concentration (MNTC) of the extracts used in antiviral assay was 25 mu g mL(-1) for Aspidosperma tomentosum and Gaylussacia brasiliensis, and 2.5 mu g mL(-1) for Arrabidaea chica and Virola sebifera. Twelve different extracts derived from four plant species collected from the Brazilian Cerrado were screened for antiviral activity against aMPV. G. brasiliensis, A. chica, and V. sebifera extracts presented inhibition rates of 99% in the early viral replication stages, suggesting that these extracts act during the adsorption phase. On the other hand, A. tomentosum inhibited 99% virus replication after the virus entered the cell. The biomonitored fractioning of extracts active against aMPV may be a tool to identify the active compounds of plant extracts and to determine their precise mode of action.
dc.description17
dc.description3
dc.description
dc.description275
dc.description280
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2008/00700-4]
dc.descriptionFAPESP [2008/00331-9]
dc.descriptionCNPq [503259/2011-1]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherFACTA-FUNDACIO ARNCO CIENCIA TECNOLOGIA AVICOLAS
dc.publisher
dc.publisherCAMPINAS
dc.relationBRAZILIAN JOURNAL OF POULTRY SCIENCE
dc.rightsfechado
dc.sourceWOS
dc.subjectTumor-cell Lines
dc.subject100,000-compound Library
dc.subjectAssay
dc.subjectInhibitors
dc.subjectGrowth
dc.subjectAgents
dc.subjectH3n2
dc.titleIn-vitro Antiviral Activities Of Extracts Of Plants Of The Brazilian Cerrado Against The Avian Metapneumovirus (ampv)
dc.typeArtículos de revistas


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