Ritualistic Use Of Ayahuasca Versus Street Use Of Similar Substances Seized By The Police: A Key Factor Involved In The Potential For Intoxications And Overdose?

dc.creatorLanaro
dc.creatorRafael; de Aquino Calemi
dc.creatorDebora Bressanim; Togni
dc.creatorLoraine Rezende; Costa
dc.creatorJose Luiz; Yonamine
dc.creatorMauricio; Santos Cazenave
dc.creatorSilvia de Oliveira; Linardi
dc.creatorAlessandra
dc.date2015-Mar
dc.date2016-06-07T13:15:43Z
dc.date2016-06-07T13:15:43Z
dc.date.accessioned2018-03-29T01:36:25Z
dc.date.available2018-03-29T01:36:25Z
dc.identifier
dc.identifierRitualistic Use Of Ayahuasca Versus Street Use Of Similar Substances Seized By The Police: A Key Factor Involved In The Potential For Intoxications And Overdose?. Routledge Journals, Taylor & Francis Ltd, v. 47, p. 132-139 Mar-2015.
dc.identifier0279-1072
dc.identifierWOS:000354040800006
dc.identifier10.1080/02791072.2015.1013202
dc.identifierhttp://www.tandfonline.com/doi/abs/10.1080/02791072.2015.1013202?journalCode=ujpd20#.VytHKNIrLcc
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241941
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305639
dc.descriptionThe ritualistic use of ayahuasca is becoming a global phenomenon. This beverage contains a combination of monoamine oxidase inhibitors (harmine, harmaline, and tetrahydroharmine) and N,N-dimethyltryptamine, the main substance responsible for its visionary effect. The recreational use of similar alkaloids and N,N-dimethyltryptamine has increased in recent years, mainly because of their hallucinogenic effects. In the present study, the concentrations of psychoactive alkaloids in three powder samples seized by the Sao Paulo State Police and nine ayahuasca aqueous extracts were analyzed by HPLC-DAD in an attempt to distinguish between illicit drugs and the religious beverage. The alkaloids detected (mu g/mL) in the ayahuasca aqueous extracts were N,N-dimethyltryptamine (402-2070.3), harmaline (27.5-181.3), harmine (294.5-2893.8), and tetrahydroharmine (849.5-2052.5), whereas, of the three powder samples, one contained only N,N-dimethyltryptamine (82% and 2% w/w, respectively) while the other contained only harmaline (16%, w/w) and harmine (12%, w/w). The ritualistic use of ayahuasca involves oral intake and the probability of overdose is minimized by serotonergic stimulation of vagal pathways, leading to vomiting and diarrhea. In contrast, the recreational use of N,N-dimethyltryptamine involves consumption mainly by smoking or inhalation, both of which markedly increase its bioavailability and the potential for intoxications.
dc.description47
dc.description2
dc.description
dc.description132
dc.description139
dc.descriptionFAP of Santa Casa de Sao Paulo School of Medical Sciences
dc.description
dc.description
dc.description
dc.languageen
dc.publisherROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
dc.publisher
dc.publisherABINGDON
dc.relationJOURNAL OF PSYCHOACTIVE DRUGS
dc.rightsembargo
dc.sourceWOS
dc.subjectBeta-carboline Alkaloids
dc.subjectDimethyltryptamine Dmt
dc.subjectHarmala Alkaloids
dc.subjectHuman Plasma
dc.subjectN,n-dimethyltryptamine
dc.subjectInternet
dc.subjectHumans
dc.subject5-methoxy-n,n-dimethyltryptamine
dc.subjectPharmacology
dc.subjectChallenges
dc.titleRitualistic Use Of Ayahuasca Versus Street Use Of Similar Substances Seized By The Police: A Key Factor Involved In The Potential For Intoxications And Overdose?
dc.typeArtículos de revistas


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