Intermittent Administration Of Parathyroid Hormone Improves The Repairing Process Of Rat Calvaria Defects: A Histomorphometric And Radiodensitometric Study

dc.creatorSilva
dc.creatorEduardo-de-Paula; Vasconcelos
dc.creatorDaniel-Fernando-Pereira; Marques
dc.creatorMarcelo-Rocha; da Silva
dc.creatorMarco-Antonio Dias; Manzi
dc.creatorFlavio-Ricardo; Barros
dc.creatorSilvana-Pereira
dc.date2015-JUL
dc.date2016-06-07T13:15:33Z
dc.date2016-06-07T13:15:33Z
dc.date.accessioned2018-03-29T01:36:16Z
dc.date.available2018-03-29T01:36:16Z
dc.identifier
dc.identifierIntermittent Administration Of Parathyroid Hormone Improves The Repairing Process Of Rat Calvaria Defects: A Histomorphometric And Radiodensitometric Study. Medicina Oral S L, v. 20, p. E489-E493 JUL-2015.
dc.identifier1698-6946
dc.identifierWOS:000365267200014
dc.identifier10.4317/medoral.20412
dc.identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523262/
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241902
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305600
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionBackground: The aim of this study was to evaluate the effects of intermittent treatment of parathyroid hormone (PTH (1-34)) on the bone regeneration of critically-sized rat calvarial bone defects. Material and Methods: Thirty-two male rats were trephined (4mm fullthickness diameter), in the central part of the parietal bones and divided into 2 groups of 16. The PTH group received subcutaneous injections of PTH (1-34) at 40 mu g/kg, 3 times a week and the control (CTL) group received the vehicle in the same regimen. The rats were sacrificed at 4 weeks post-treatment regimen, the parietal bones were extracted and samples were evaluated through histomorphometry and radiodensitometry. Results: The histological observations showed that the PTH group presented more "island-like" new bone between the defect margins with fibrous tissues than did the CTL group. The PTH group significantly exhibited greater histologic bone formation than did the CTL group (1.5mm +/- 0.7; 1.9 mm +/- 0.6, p<0.05/ for residual bone defect). The radiodensitometry analysis revealed significant differences among the PTH and CTL groups (2.1 Al eq. +/- 0.04; 1.8Al eq. +/- 0.06, p<0.05), demonstrating an increase in bone mineral density. The PTH treatment contributed to the bone formation with a higher amount of mineral and/or fibrous tissue when compared with the CTL group. Conclusions: The results suggest that it was possible to increase the process of bone regeneration by accelerating the healing process in rat calvarial defects through intermittent administration of the PTH treatment.
dc.description20
dc.description4
dc.description
dc.descriptionE489
dc.descriptionE493
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description
dc.description
dc.description
dc.languageen
dc.publisherMEDICINA ORAL S L
dc.publisher
dc.publisherVALENCIA
dc.relationMEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
dc.rightsfechado
dc.sourceWOS
dc.subjectBone-mineral Density
dc.subjectCritical-size Defect
dc.subjectPostmenopausal Women
dc.subjectOvariectomized Rats
dc.subjectMechanical Strength
dc.subjectOsteoporosis
dc.subjectFractures
dc.subjectModel
dc.subjectPth
dc.subjectRegeneration
dc.titleIntermittent Administration Of Parathyroid Hormone Improves The Repairing Process Of Rat Calvaria Defects: A Histomorphometric And Radiodensitometric Study
dc.typeArtículos de revistas


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