The Stem Cell Marker Bmi-1 Is Sensitive In Identifying Early Lesions Of Carcinoma Ex Pleomorphic Adenoma

dc.creatorSedassari
dc.creatorBruno Tavares; Setubal Destro Rodrigues
dc.creatorMaria Fernanda; Mariano
dc.creatorFernanda Viviane; Altemani
dc.creatorAlbina; Nunes
dc.creatorFabio Daumas; Sousa
dc.creatorSuzana
dc.date2015-JUL
dc.date2016-06-07T13:15:31Z
dc.date2016-06-07T13:15:31Z
dc.date.accessioned2018-03-29T01:36:15Z
dc.date.available2018-03-29T01:36:15Z
dc.identifier
dc.identifierThe Stem Cell Marker Bmi-1 Is Sensitive In Identifying Early Lesions Of Carcinoma Ex Pleomorphic Adenoma. Lippincott Williams & Wilkins, v. 94, p. JUL-2015.
dc.identifier0025-7974
dc.identifierWOS:000360857000001
dc.identifier10.1097/MD.0000000000001035
dc.identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504655/
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241899
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305597
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionIn the present study, we evaluated and described the sensitivity of the stem cell marker B cell-specific moloney murine leukemia virus integration site 1 (Bmi-1) in identifying early lesions of carcinoma ex pleomorphic adenoma (CXPA). While invasive CXPAs are tumors with a prominent and easily recognizable malignant component, the identification of early carcinomatous changes in PA remains a diagnostic challenge due to the lack of objective morphological criteria. The immunohistochemical expression of Bmi-1 was assessed in both adenomatous and carcinomatous components of 9 CXPA cases at an early phase of histological progression (6 intracapsular and 3 minimally invasive) grouped according to the cellular differentiation as luminal (7 cases) or myoepithelial (2 cases). A selective nuclear expression of Bmi-1 was found exclusively in the malignant component of 8 cases (6 luminal type and 2 myoepithelial type), including intraductal carcinoma areas, except for 1 case in which scarce cells of the remnant PA were positive. Thus, Bmi-1 is expressed from the earliest morphologically detectable stages of PA malignant transformation. When faced with atypical features in PA, evaluation of Bmi-1 expression can provide more objective criteria for identification and diagnosis of early lesions of CXPA. This is applied to carcinomas with luminal or myoepithelial differentiation.
dc.description94
dc.description27
dc.description
dc.description
dc.description
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [process 2012/00786-1]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.publisher
dc.publisherPHILADELPHIA
dc.relationMEDICINE
dc.rightsaberto
dc.sourceWOS
dc.subjectMalignant-transformation
dc.subjectNeoplastic-cells
dc.subjectFocal Carcinoma
dc.subjectSalivary-gland
dc.subjectCancer
dc.subjectExpression
dc.subjectProgression
dc.subjectTumor
dc.subjectImmunohistochemistry
dc.subjectCarcinogenesis
dc.titleThe Stem Cell Marker Bmi-1 Is Sensitive In Identifying Early Lesions Of Carcinoma Ex Pleomorphic Adenoma
dc.typeArtículos de revistas


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