Facing Hymenoptera Venom Allergy: From Natural To Recombinant Allergens

dc.creatorPerez-Riverol
dc.creatorAmilcar; Justo-Jacomini
dc.creatorDebora Lais; Zollner
dc.creatorRicardo de Lima; Brochetto-Braga
dc.creatorMarcia Regina
dc.date2015-JUL
dc.date2016-06-07T13:15:29Z
dc.date2016-06-07T13:15:29Z
dc.date.accessioned2018-03-29T01:36:13Z
dc.date.available2018-03-29T01:36:13Z
dc.identifier
dc.identifierFacing Hymenoptera Venom Allergy: From Natural To Recombinant Allergens. Mdpi Ag, v. 7, p. 2551-2570 JUL-2015.
dc.identifier2072-6651
dc.identifierWOS:000359191200013
dc.identifier10.3390/toxins7072551
dc.identifierhttp://www.mdpi.com/2072-6651/7/7/2551
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241890
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305588
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionAlong with food and drug allergic reactions, a Hymenoptera insect Sting (Apoidea, Vespidae, Formicidae) is one of the most common causes of anaphylaxis worldwide. Diagnoses of Hymenoptera venom allergy (HVA) and specific immunotherapy (SIT) have been based on the use of crude venom extracts. However, the incidence of cross-reactivity and low levels of sensibility during diagnosis, as well as the occurrence of nonspecific sensitization and undesired side effects during SIT, encourage the search for novel allergenic materials. Recombinant allergens are an interesting approach to improve allergy diagnosis and SIT because they circumvent major problems associated with the use of crude venom. Production of recombinant allergens depends on the profound molecular characterization of the natural counterpart by combining some omics approaches with high-throughput screening techniques and the selection of an appropriate system for heterologous expression. To date, several clinically relevant allergens and novel venom toxins have been identified, cloned and characterized, enabling a better understanding of the whole allergenic and envenoming processes. Here, we review recent findings on identification, molecular characterization and recombinant expression of Hymenoptera venom allergens and on the evaluation of these heterologous proteins as valuable tools for tackling remaining pitfalls on HVA diagnosis and immunotherapy.
dc.description7
dc.description7
dc.description
dc.description2551
dc.description2570
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionPrope-UNESP (Pro Reitoria da Universidade Estadual Paulista, SP) [10/2014]
dc.descriptionPrograma de Internacionalizacao da Pesquisa da UNESP [Prope-PROINTER-UNESP-04/2015]
dc.descriptionFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description
dc.description
dc.description
dc.languageen
dc.publisherMDPI AG
dc.publisher
dc.publisherBASEL
dc.relationTOXINS
dc.rightsaberto
dc.sourceWOS
dc.subjectReactive Carbohydrate Determinants
dc.subjectApi M 1
dc.subjectComponent-resolved Diagnosis
dc.subjectBasophil Activation Test
dc.subjectWasp Polybia-paulista
dc.subjectHoney-bee Venom
dc.subjectMolecular-cloning
dc.subjectMajor Allergens
dc.subjectSublingual Immunotherapy
dc.subjectTranscriptomic Analysis
dc.titleFacing Hymenoptera Venom Allergy: From Natural To Recombinant Allergens
dc.typeArtículos de revistas
dc.typeResumo


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