Effects Of High-dose Cisplatin Chemotherapy And Conventional Radiotherapy On Urinary Oxidative And Nitrosative Stress Biomarkers In Patients With Head And Neck

dc.creatorTuan
dc.creatorBruna T.; Visacri
dc.creatorMarilia B.; Amaral
dc.creatorLais S.; Baldini
dc.creatorDaniele; Ferrari
dc.creatorGraziele B.; Quintanilha
dc.creatorJulia C. F.; Pincinato
dc.creatorEder C.; Mazzola
dc.creatorPriscila G.; Lima
dc.creatorCarmen S. P.; Moriel
dc.creatorPatricia
dc.date2016-JAN
dc.date2016-06-07T13:14:49Z
dc.date2016-06-07T13:14:49Z
dc.date.accessioned2018-03-29T01:35:34Z
dc.date.available2018-03-29T01:35:34Z
dc.identifier
dc.identifierEffects Of High-dose Cisplatin Chemotherapy And Conventional Radiotherapy On Urinary Oxidative And Nitrosative Stress Biomarkers In Patients With Head And Neck. Wiley-blackwell, v. 118, p. 83-86 JAN-2016.
dc.identifier1742-7835
dc.identifierWOS:000368184200013
dc.identifier10.1111/bcpt.12443
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/bcpt.12443/abstract
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241723
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305421
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCisplatin is a chemotherapeutic agent widely used in the treatment of several solid tumours. For patients with advanced head and neck squamous cell carcinoma in whom surgery is contraindicated, treatment with high-dose cisplatin administered every 21 days for 3 cycles concomitantly with conventional radiotherapy is recommended [1-3]. Its anticancer mechanism is mediated by DNA binding, which leads to the formation of inter-and intrastrand crosslinks and results in defective DNA templates, arrest of DNA synthesis and replication, DNA damage and, finally, cell death [4]. In addition, cisplatin accumulates in human cells (normal and tumour cells) resulting in enhanced production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which leads to mitochondrial damage and dysfunction [5,6]. In addition, there is a decrease in the antioxidant defence system mediated primarily by links formed between cisplatin and glutathione, which culminates in the depletion of glutathione [7]. The excessive generation of ROS and RNS damages biomolecules, resulting in lipid, protein and DNA/RNA oxidation and causing toxicities including nephrotoxicity, neurotoxicity, ototoxicity and hepatotoxicity [8-11]. The intensity of biomolecular damage can be determined by oxidative/nitrosative stress biomarkers. In this study, we used malondialdehyde (MDA) and lipid hydroperoxides, which are indicators of lipid peroxidation/oxidative stress biomarkers and nitrite, a nitrosative stress biomarker. Therefore, the aim of this study was to determine the effects of high-dose cisplatin chemotherapy and conventional radiotherapy on urinary levels of MDA, lipid hydroperoxides and nitrite biomarkers in patients with head and neck
dc.description118
dc.description1
dc.description
dc.description83
dc.description86
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description
dc.description
dc.description
dc.languageen
dc.publisherWILEY-BLACKWELL
dc.publisher
dc.publisherHOBOKEN
dc.relationBASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
dc.rightsfechado
dc.sourceWOS
dc.subjectInduced Nephrotoxicity
dc.subjectRadiation-therapy
dc.subjectCancer-patients
dc.subjectGuinea-pigs
dc.subjectCarcinoma
dc.subjectRats
dc.subjectToxicity
dc.subjectInjury
dc.subjectAcid
dc.titleEffects Of High-dose Cisplatin Chemotherapy And Conventional Radiotherapy On Urinary Oxidative And Nitrosative Stress Biomarkers In Patients With Head And Neck
dc.typeArtículos de revistas


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