Endocannabinoids, Through Opioids And Prostaglandins, Contribute To Fever Induced By Key Pyrogenic Mediators

dc.creatorFraga
dc.creatorDaniel; Zanoni
dc.creatorCristiane I. S.; Zampronio
dc.creatorAleksander R.; Parada
dc.creatorCarlos A.; Rae
dc.creatorGiles A.; Souza
dc.creatorGloria E. P.
dc.date2016-JAN
dc.date2016-06-07T13:14:25Z
dc.date2016-06-07T13:14:25Z
dc.date.accessioned2018-03-29T01:35:11Z
dc.date.available2018-03-29T01:35:11Z
dc.identifier
dc.identifierEndocannabinoids, Through Opioids And Prostaglandins, Contribute To Fever Induced By Key Pyrogenic Mediators. Academic Press Inc Elsevier Science, v. 51, p. 204-211 JAN-2016.
dc.identifier0889-1591
dc.identifierWOS:000366619100019
dc.identifier10.1016/j.bbi.2015.08.014
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0889159115004705
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241632
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305330
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThis study aims to explore the contribution of endocannabinoids on the cascade of mediators involved in LPS-induced fever and to verify the participation of prostaglandins and endogenous opioids in fever induced by anandamide (AEA). Body temperature (Tc) of male Wistar rats was recorded over 6 h, using a thermistor probe. Cerebrospinal fluid concentration of PGE(2) and beta-endorphin were measured by ELISA after the administration of AEA. Intracerebroventricular administration of the CBI receptor antagonist AM251 (5 pig, i.c.v.), reduced the fever induced by IL-1 beta (3 ng, i.c.v.), TNF-alpha (250 ng, i.c.v.), IL-6 (300 ng, i.c.v.), corticotrophin release factor (CRH; 2.5 mu g, i.c.v.) and endothelin (ET)-1 (1 pmol, i.c.v.), but not the fever induced by PGE(2) (250 ng, i.c.v.) or PGF(2 alpha), (250 ng, i.c.v.). Systemic administration of indomethacin (2 mg kg(-1), i.p.) or celecoxib (5 mg kg(-1), p.o.) reduced the fever induced by AEA (1 mu g, i.c.v.), while naloxone (1 mg kg(-1), s.c.) abolished it. The increases of PGE(2) and beta-endorphin concentration in the CSF induced by AEA were abolished by the pretreatment of rats with AM251. These results suggest that endocannabinoids are intrinsically involved in the pyretic activity of cytokines (IL-1 beta, TNF-alpha, IL-6), CRH and ET-1 but not the PGE(2) or PGF(2 alpha), induced fevers. However, anandamide via CB1 receptor activation induces fever that is dependent on the synthesis of prostaglandin and opioids. (C) 2015 Elsevier Inc. All rights reserved.
dc.description51
dc.description
dc.description
dc.description204
dc.description211
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCNPq [CNPq 304627/2007-0]
dc.descriptionFAPESP [FAPESP 2007/04791-1]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.publisher
dc.publisherSAN DIEGO
dc.relationBRAIN BEHAVIOR AND IMMUNITY
dc.rightsembargo
dc.sourceWOS
dc.subjectReceptor-selective Antagonist
dc.subjectCannabinoid 1 Receptors
dc.subjectEndothelial-cells
dc.subjectCb1 Receptors
dc.subjectEndogenous Cannabinoids
dc.subjectIndependent Fever
dc.subjectAnxiety-like
dc.subjectAnandamide
dc.subjectRats
dc.subjectSystem
dc.titleEndocannabinoids, Through Opioids And Prostaglandins, Contribute To Fever Induced By Key Pyrogenic Mediators
dc.typeArtículos de revistas


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