The Effects Of Nampt Haplotypes And Metabolic Risk Factors On Circulating Visfatin/nampt Levels In Childhood Obesity

dc.creatorBelo
dc.creatorV. A.; Luizon
dc.creatorM. R.; Lacchini
dc.creatorR.; Miranda
dc.creatorJ. A.; Lanna
dc.creatorC. M. M.; Souza-Costa
dc.creatorD. C.; Tanus-Santos
dc.creatorJ. E.
dc.date2015-JAN
dc.date2016-06-07T13:14:08Z
dc.date2016-06-07T13:14:08Z
dc.date.accessioned2018-03-29T01:34:57Z
dc.date.available2018-03-29T01:34:57Z
dc.identifier
dc.identifierThe Effects Of Nampt Haplotypes And Metabolic Risk Factors On Circulating Visfatin/nampt Levels In Childhood Obesity. Nature Publishing Group, v. 39, p. 130-135 JAN-2015.
dc.identifier0307-0565
dc.identifierWOS:000347394000019
dc.identifier10.1038/ijo.2013.173
dc.identifierhttp://www.nature.com/ijo/journal/v39/n1/full/ijo2013173a.html
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241569
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305267
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionOBJECTIVE: Polymorphisms in the NAMPT gene, which encodes the adipocytokine visfatin/nicotinamide phosphorybosil transferase (NAMPT), affect the circulating visfatin/NAMPT levels and are associated with obesity and cardiovascular diseases. However, no study has tested the hypothesis that NAMPT haplotypes could affect visfatin/NAMPT levels in case of childhood obesity. We investigated the effects of traditional metabolic risk factors (MRFs) and NAMPT polymorphisms T/C (rs1319501) and A/G (rs3801266) or haplotypes on visfatin/NAMPT levels in obese children and adolescents, and whether NAMPT polymorphisms and/or haplotypes are associated with susceptibility to childhood obesity. METHODS: We studied 175 control, 99 obese and 82 obese with >= 3 MRFs children and adolescents. Genotypes were determined by a Taqman allele discrimination assay and real- time PCR. The plasma visfatin/NAMPT level was measured using an enzyme immunoassay. RESULTS: Obese children and adolescents with >= 3 MRFs had higher plasma visfatin/NAMPT levels in comparison with control children and adolescents (P < 0.05). Although positive associations were observed between visfatin/NAMPT and body mass index (rs = 0.157; P = 0.034) as well as visfatin/NAMPT and waist circumference (rs = 0.192; P = 0.011), visfatin/NAMPT and high- density lipoprotein cholesterol were inversely associated (rs = -0.162; P = 0.031). No significant differences in genotype, allele or haplotype frequency distributions for the studied polymorphisms were found when the three groups were compared. However, higher plasma visfatin/NAMPT levels were found in control and obese subjects carrying the GG genotype for the A/G (rs3801266) polymorphism (P < 0.05) but not in obese children with X3 MRFs. Moreover, control subjects carrying the 'T-G' haplotype showed higher plasma visfatin/NAMPT levels. NAMPT genotypes or haplotypes were not associated with childhood obesity. CONCLUSIONS: Obesity in children with >= 3 MRFs increases plasma visfatin/NAMPT levels, and this marker was associated with body mass index and waist circumference. The A/G polymorphism and NAMPT haplotypes affect plasma visfatin/NAMPT levels in controls but not in obese children with >= 3 MRFs. These results suggest that obesity and MRFs are more influential than genetic polymorphisms in the determination of visfatin/NAMPT levels in obese children. Further research is necessary to explain why the GG genotype is not associated with increased visfatin/NAMPT levels in obese children with >= 3 MRFs.
dc.description39
dc.description1
dc.description
dc.description130
dc.description135
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description
dc.description
dc.description
dc.languageen
dc.publisherNATURE PUBLISHING GROUP
dc.publisher
dc.publisherLONDON
dc.relationINTERNATIONAL JOURNAL OF OBESITY
dc.rightsfechado
dc.sourceWOS
dc.subjectType-2 Diabetes-mellitus
dc.subjectHomeostasis Model Assessment
dc.subjectInsulin-resistance
dc.subjectSerum Visfatin
dc.subjectGlucose-metabolism
dc.subjectGenetic-variations
dc.subjectAdipose-tissue
dc.subjectVisceral Fat
dc.subjectChildren
dc.subjectAdolescents
dc.titleThe Effects Of Nampt Haplotypes And Metabolic Risk Factors On Circulating Visfatin/nampt Levels In Childhood Obesity
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución