Properties Of Pia/pcl Particles As Vehicles For Oral Delivery Of The Androgen Hormone 17 Alpha-methyltestosterone

dc.creatorCosta Sacchetin
dc.creatorPriscila Soares; Setti
dc.creatorRafaela Ferreira; Vieira e Rosa
dc.creatorPaulo de Tarso; Moraes
dc.creatorAngela Maria
dc.date2016-JAN
dc.date2016-06-07T13:14:03Z
dc.date2016-06-07T13:14:03Z
dc.date.accessioned2018-03-29T01:34:51Z
dc.date.available2018-03-29T01:34:51Z
dc.identifier
dc.identifierProperties Of Pia/pcl Particles As Vehicles For Oral Delivery Of The Androgen Hormone 17 Alpha-methyltestosterone. Elsevier Science Bv, v. 58, p. 870-881 JAN-2016.
dc.identifier0928-4931
dc.identifierWOS:000364247500103
dc.identifier10.1016/j.msec.2015.09.071
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0928493115303908
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241549
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305247
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe aim of this study was to produce PLA (poly(lactic add)) and PCL (polycaprolactone) oral carriers through the precipitation of the polymer solutions using supercritical CO2 as an antisolvent for the controlled release of the hydrophobic model drug 17 alpha-methyltestosterone (MT). Such drug is a steroidal hormone used orally to develop and sustain primary and secondary male sex characteristics, e.g. for female Nile tilapia sex reversal in aquaculture. The influence of hormone, PIA and PCL concentrations on particle formation was analyzed, showing that high PCL concentrations produced particles with rougher surfaces and greater mean diameters. The incorporation efficiency of MT ranged from 20 to 51%, and its addition resulted in increases in particle mean diameter from 23 to 54 mu m. Aggregation was observed for particles incorporating or not MT and high concentrations of MT led to the formation of more amorphous structures, changing the thermal behavior of the particles. The exposure of the PLA/PCL particles to pH conditions simulating gastrointestinal fish conditions showed that hormone release fraction at acidic pH ranged from 8 to 63% (over 2 h), while in the basic pH the proportion released varied from 23 to 60% (over 10 h), reaching levels adequate for the desired in vivo activity. (C) 2015 Published by Elsevier B.V.
dc.description58
dc.description
dc.description
dc.description870
dc.description881
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCNPq [473013/2009-6]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherELSEVIER SCIENCE BV
dc.publisher
dc.publisherAMSTERDAM
dc.relationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
dc.rightsembargo
dc.sourceWOS
dc.subjectAnti-solvent Process
dc.subjectDrug-delivery
dc.subjectSupercritical Fluids
dc.subjectLactic-acid
dc.subjectRelease
dc.subjectBlends
dc.subjectMicrospheres
dc.subjectMicroparticles
dc.subjectPrecipitation
dc.subjectPolymers
dc.titleProperties Of Pia/pcl Particles As Vehicles For Oral Delivery Of The Androgen Hormone 17 Alpha-methyltestosterone
dc.typeArtículos de revistas


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