Preparation And Characterization Of Glycidyl Methacrylate Organo Bridges Grafted Mesoporous Silica Sba-15 As Ibuprofen And Mesalamine Carrier For Controlled Release

dc.creatorRehman
dc.creatorFozia; Rahim
dc.creatorAbdur; Airoldi
dc.creatorClaudio; Volpe
dc.creatorPedro L. O.
dc.date2016-FEB
dc.date2016-06-07T13:13:32Z
dc.date2016-06-07T13:13:32Z
dc.date.accessioned2018-03-29T01:34:34Z
dc.date.available2018-03-29T01:34:34Z
dc.identifier
dc.identifierPreparation And Characterization Of Glycidyl Methacrylate Organo Bridges Grafted Mesoporous Silica Sba-15 As Ibuprofen And Mesalamine Carrier For Controlled Release. Elsevier Science Bv, v. 59, p. 970-979 FEB-2016.
dc.identifier0928-4931
dc.identifierWOS:000367107400114
dc.identifier10.1016/j.msec.2015.11.005
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0928493115305373
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/241498
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305196
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionMesoporous silica SBA-15 was synthesized and functionalized with bridged polysilsesquioxane monomers obtained by the reaction of 3-aminopropyltriethoxy silane with glycidyl methacrylate in 2:1 ratio. The synthesized mesoporous silica materials were characterized by elemental analysis, infrared spectroscopy, nuclear magnetic resonance spectroscopy, nitrogen adsorption, X-ray diffraction, thermogravimetry and scanning electron microscopy. The nuclear magnetic resonance in the solid state is in agreement with the sequence of carbon distributed in the attached organic chains, as expected for organically functionalized mesoporous silica. After functionalization with organic bridges the BET surface area was reduced from 1311.80 to 494,2 m(2) g(-1), and pore volume was reduced from 1.98 to 0.89 cm(2) g(-1), when compared to original precursor silica. Modification of the silica surface with organic bridges,resulted in high loading capacity and controlled release of ibuprofen and mesalamine in biological fluids. The Korsmeyer-Peppas model better fits the release data indicating FicIdan diffusion and zero order kinetics for synthesized mesoporous silica. The drug release rate from the modified silica was slow in simulated gastric fluid, (pH 1.2) where less than 10% of mesalamine and ibuprofen were released in initial 8 h, while comparatively high release rates were observed in simulated intestinal (pH 6.8) and simulated body fluids (pH 7.2). The preferential release of mesalamine at-intestinal pH suggests that the modified silica could be a simple, efficient, inexpensive and convenient carrier for colon targeted drugs, such a mesalamine and also as a controlled drug release system. (C) 2015 Elsevier B.V. All rights reserved.
dc.description59
dc.description
dc.description
dc.description970
dc.description979
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description
dc.description
dc.description
dc.languageen
dc.publisherELSEVIER SCIENCE BV
dc.publisher
dc.publisherAMSTERDAM
dc.relationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
dc.rightsembargo
dc.sourceWOS
dc.subjectDrug-delivery Systems
dc.subjectAqueous-solution
dc.subjectNanoparticles
dc.subjectSurface
dc.subjectCopolymer
dc.subjectTriblock
dc.subjectRemoval
dc.subjectSpheres
dc.subjectAmino
dc.subjectSize
dc.titlePreparation And Characterization Of Glycidyl Methacrylate Organo Bridges Grafted Mesoporous Silica Sba-15 As Ibuprofen And Mesalamine Carrier For Controlled Release
dc.typeArtículos de revistas


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