| dc.date | 2016 | |
| dc.date | 2016-06-03T20:15:47Z | |
| dc.date | 2016-06-03T20:15:47Z | |
| dc.date.accessioned | 2018-03-29T01:34:22Z | |
| dc.date.available | 2018-03-29T01:34:22Z | |
| dc.identifier | | |
| dc.identifier | Vox Sanguinis. Blackwell Publishing Ltd, v. 110, n. 1, p. 70 - 78, 2016. | |
| dc.identifier | 429007 | |
| dc.identifier | 10.1111/vox.12315 | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84956573251&partnerID=40&md5=2766830309694f47c14a1b7002c326b0 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/238487 | |
| dc.identifier | 2-s2.0-84956573251 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1305148 | |
| dc.description | Background and Objectives: Transfusion support for immune-mediated platelet refractoriness (PR) is clinically challenging, technically laborious and costly. The development of 'EpHLA/EpVix software' has been used successfully to select kidney donors. Here, we sought to evaluate this new software as a tool for platelet virtual crossmatch (VxM). Materials and Methods: This is a prospective study from 2007 to 2014 of PR patients in a tertiary hospital. Platelet components selected by HLAMatchmaker program were crossmatched by EpHLA/EpVix, anti-human globulin complement-dependent lymphocytotoxicity test (AHG-CDC), flow cytometry platelet crossmatch (FCxM) and then compared. Effectiveness of platelet components transfused was evaluated by CCI. Results: Ninety-seven crossmatched platelet transfusions for 27 patients were enrolled. Partial matches were analysed for 75 transfusions by the 3 methods, and 22% showed discrepant results among the assays. After further analysis, data showed that all divergent cases could be explained by HPA alloimmunization, prozone effect (FCxM), low sensitivity of AHG-CDC and possible interference in FCxM/AHG-CDC assays. Notably, sensitivity and specificity of VxM analysis was excellent (100%). Satisfactory CCI counts were obtained for the majority (22/30) of the transfusions. Conclusion: The new EpHLA/EpVix method showed to be effective, feasible and fast for VxM at no cost and able to minimize labour on donor identification. However, platelet crossmatching may be a necessary step because EpHLA/EpVix does not formally exclude HPA alloimmunization. © 2016 International Society of Blood Transfusion. | |
| dc.description | 110 | |
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| dc.description | | |
| dc.description | | |
| dc.language | en | |
| dc.publisher | Blackwell Publishing Ltd | |
| dc.relation | Vox Sanguinis | |
| dc.rights | embargo | |
| dc.source | Scopus | |
| dc.title | The Use Of A Potential Novel Tool In Virtual Crossmatching For Platelet Transfusion In Platelet Refractoriness | |
| dc.type | Artículos de revistas | |
