| dc.date | 2016 | |
| dc.date | 2016-06-03T20:15:37Z | |
| dc.date | 2016-06-03T20:15:37Z | |
| dc.date.accessioned | 2018-03-29T01:34:14Z | |
| dc.date.available | 2018-03-29T01:34:14Z | |
| dc.identifier | | |
| dc.identifier | Separation And Purification Technology. Elsevier, v. 158, p. 204 - 211, 2016. | |
| dc.identifier | 13835866 | |
| dc.identifier | 10.1016/j.seppur.2015.12.007 | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84951152853&partnerID=40&md5=70a362bf83292b24afac5ebccc938499 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/238454 | |
| dc.identifier | 2-s2.0-84951152853 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1305115 | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.description | Extracts rich in lignans were obtained from Phyllanthus amarus by Pressurized Liquid Extraction (PLE). The influences of temperature and solvent type on the extraction yield and chemical composition of the extracts were evaluated. Temperature was evaluated from 35°C to 80°C and the used solvents were: water, ethanol and a mixture of ethanol + water (50% v/v). All extractions were performed at the pressure of 10 MPa. A low pressure extraction method (LPE) using the Ultra-Turrax disperser and the same solvents, at room temperature and atmospheric pressure, was performed to compare the results with those of PLE. The extracts were analyzed by Gas Chromatography coupled to Mass Spectrometry (GC-MS) and seven lignans were identified: 5-demethoxy-niranthin, phyllanthin, filtetralin, 5-demethoxy-nirtetralin, nirtetralin, hipophyllanthin and niranthin. High Performance Liquid Chromatography (HPLC) was used to quantify the most bioactive lignans, phyllanthin and niranthin, in the extracts. In the PLE method, the effect of temperature was negligible in the studied range for the recovery of these lignans. The binary mixture ethanol + water (50% v/v) was the best solvent for the recovery of high amounts of both lignans, independently of the extraction method. However, PLE with 100% ethanol provided the most concentrated extracts in both lignans. PLE achieved higher global extraction yield than in LPE, but lower lignan recoveries. The contents of the major lignans extracted by each method varied significantly, suggesting that phyllanthin and niranthin are located in different parts of the plant tissue. The selection of the best method to extract lignans form P. amarus depends on the operation costs. © 2015 Elsevier B.V. All rights reserved. | |
| dc.description | 158 | |
| dc.description | | |
| dc.description | 204 | |
| dc.description | 211 | |
| dc.description | 2012/22119-7, CAPES, Fundação de Amparo à Pesquisa do Estado de São Paulo | |
| dc.description | 2012/22119-7, FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo | |
| dc.description | 2013/02203-6, CAPES, Fundação de Amparo à Pesquisa do Estado de São Paulo | |
| dc.description | 2013/02203-6, FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo | |
| dc.description | 473342/2011-1, CNPq, Fundação de Amparo à Pesquisa do Estado de São Paulo | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.description | Aruna Kumar, R., Raju, B., Umesha, K., Smitha, G.R., Sreeramu, B.S., Integrated nutrient management on growth, yield, quality and economics of Bhumyamalaki (Phyllanthus amarus) - An anti-jaundice plant (2010) J. Med. Aromat. Plants., 1, pp. 34-39 | |
| dc.description | Kumaran, A., Karunakaran, R.J., In vitro antioxidant activities of methanol extracts of five Phyllanthus species from India (2007) LWT - Food Sci. Technol., 40, pp. 344-352 | |
| dc.description | Sprenger, R.D.F., Cass, Q.B., Characterization of four Phyllanthus species using liquid chromatography coupled to tandem mass spectrometry (2013) J. Chromatogr. A, 1291, pp. 97-103 | |
| dc.description | Patel, J.R., Tripathi, P., Sharma, V., Chauhan, N.S., Dixit, V.K., Phyllanthus amarus: Ethnomedicinal uses, phytochemistry and pharmacology: A review (2011) J. Ethnopharmacol., 138, pp. 286-313 | |
| dc.description | Ezuruike, U.F., Prieto, J.M., The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations (2013) J. Ethnopharmacol., 155, pp. 857-924 | |
| dc.description | Khatoon, S., Rai, V., Rawat, A.K.S., Mehrotra, S., Comparative pharmacognostic studies of three Phyllanthus species (2006) J. Ethnopharmacol., 104, pp. 79-86 | |
| dc.description | Adeneye, A.A., The leaf and seed aqueous extract of Phyllanthus amarus improves insulin resistance diabetes in experimental animal studies (2012) J. Ethnopharmacol., 144, pp. 705-711 | |
| dc.description | Maity, S., Chatterjee, S., Variyar, P.S., Sharma, A., Adhikari, S., Mazumder, S., Evaluation of antioxidant activity and characterization of phenolic constituents of Phyllanthus amarus root (2013) J. Agric. Food Chem., 61, pp. 3443-3450 | |
| dc.description | Lim, Y.Y.A., Murtijaya, J., (2007) Antioxidant Properties of Phyllanthus Amarus Extracts As Affected by Different Drying Methods, 40, pp. 1664-1669 | |
| dc.description | Mahomoodally, M.F., Muthoora, D.D., Kinetic of inhibition of carbohydrate-hydrolysing enzymes, antioxidant activity and polyphenolic content of Phyllanthus amarus Schum. & Thonn. (Phyllanthaceae) (2014) Perspect. Med., 4, pp. 208-223 | |
| dc.description | Ravikumar, Y.S., Ray, U., Nandhitha, M., Perween, A., Naika, H.R., Khanna, N., Inhibition of hepatitis C virus replication by herbal extract: Phyllanthus amarus as potent natural source (2011) Virus Res., 158, pp. 89-97 | |
| dc.description | Notka, F., Meier, G., Wagner, R., (2004) Concerted Inhibitory Activities of Phyllanthus Amarus on HIV Replication in Vitro and Ex Vivo, 64, pp. 93-102 | |
| dc.description | Kassuya, C.A.L., Silvestre, A., Menezes-De-Lima, O., Marotta, D.M., Rehder, V.L.G., Calixto, J.B., Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor (2006) Eur. J. Pharmacol., 546, pp. 182-188 | |
| dc.description | Kassuya, C.A.L., Leite, D.F.P., De Melo, L.V., Rehder, V.L.G., Calixto, J.B., Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus (2005) Planta Med., 71, pp. 721-726 | |
| dc.description | Kassuya, C.A.L., Silvestre, A.A., Rehder, V.L.G., Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain (2003) Eur. J. Pharmacol., 478, pp. 145-153 | |
| dc.description | Nitnaware, K.M., Naik, D.G., Nikam, T.D., Thidiazuron-induced shoot organogenesis and production of hepatoprotective lignan phyllanthin and hypophyllanthin in Phyllanthus amarus (2010) Plant Cell, Tissue Organ Cult., 104, pp. 101-110 | |
| dc.description | Hanh, N.D., Sinchaipanid, N., Mitrevej, A., Physicochemical characterization of phyllanthin from Phyllanthus amarus Schum. & Thonn (2013) Drug Dev. Ind. Pharm., 9045, pp. 1-10 | |
| dc.description | Chowdhury, S., Mukherjee, T., Mukhopadhyay, R., Mukherjee, B., Sengupta, S., Chattopadhyay, S., The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice (2012) EMBO Mol. Med., 4, pp. 1126-1143 | |
| dc.description | Krithika, R., Mohankumar, R., Verma, R.J., Shrivastav, P.S., Mohamad, I.L., Gunasekaran, P., Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line (2009) Chem. Biol. Interact., 181, pp. 351-358 | |
| dc.description | Shen, J., Shao, X., A comparison of accelerated solvent extraction, Soxhlet extraction, and ultrasonic-assisted extraction for analysis of terpenoids and sterols in tobacco (2005) Anal. Bioanal. Chem., 383, pp. 1003-1008 | |
| dc.description | Pitipanapong, J., Chitprasert, S., Goto, M., Jiratchariyakul, W., Sasaki, M., Shotipruk, A., New approach for extraction of charantin from Momordica charantia with pressurized liquid extraction (2007) Sep. Purif. Technol., 52, pp. 416-422 | |
| dc.description | Freitas, L.S., Dariva, C., Jacques, R.A., Caramão, E.B., Effect of experimental parameters in the pressurized liquid extraction of Brazilian grape seed oil (2013) Sep. Purif. Technol., 116, pp. 313-318 | |
| dc.description | Mustafa, A., Turner, C., Pressurized liquid extraction as a green approach in food and herbal plants extraction: A review (2011) Anal. Chim. Acta, 703, pp. 8-18 | |
| dc.description | Zhang, Z.-S., Li, D., Wang, L.-J., Ozkan, N., Chen, X.D., Mao, Z.-H., Optimization of ethanol-water extraction of lignans from flaxseed (2007) Sep. Purif. Technol., 57, pp. 17-24 | |
| dc.description | Şahin, S., Samli, R., Optimization of olive leaf extract obtained by ultrasound-assisted extraction with response surface methodology (2013) Ultrason. Sonochem., 20, pp. 595-602 | |
| dc.description | Wang, X., Wu, Y., Chen, G., Yue, W., Liang, Q., Wu, Q., Optimisation of ultrasound assisted extraction of phenolic compounds from Sparganii rhizoma with response surface methodology (2013) Ultrason. Sonochem., 20, pp. 846-854 | |
| dc.description | Santos, D.T., Veggi, P.C., Meireles, M.A.A., Optimization and economic evaluation of pressurized liquid extraction of phenolic compounds from jabuticaba skins (2012) J. Food Eng., 108, pp. 444-452 | |
| dc.description | Devesa, R., Moldes, A., Díaz-Fierros, F., Barral, M.T., Extraction study of algal pigments in river bed sediments by applying factorial designs (2007) Talanta, 72, pp. 1546-1551 | |
| dc.description | Maity, S., Nag, N., Chatterjee, S., Adhikari, S., Mazumder, S., Bilirubin clearance and antioxidant activities of ethanol extract of Phyllanthus amarus root in phenylhydrazine-induced neonatal jaundice in mice (2013) J. Physiol. Biochem., 69, pp. 467-476 | |
| dc.description | Yuandani, M., Ilangkovan, I., Jantan, H.F., Mohamad, K., Husain, A.F., Razak, A., Inhibitory effects of standardized extracts of Phyllanthus amarus and Phyllanthus urinaria and their marker compounds on phagocytic activity of human neutrophils (2013) Evid.-Based Complement. Altern. Med., 2013, pp. 1-9 | |
| dc.description | Yang, Y., Hawthorne, S.B., Miller, D.J., Class-selective extraction of polar, moderately polar, and nonpolar organics from hydrocarbon wastes using subcritical water (1997) Environ. Sci. Technol., 31, pp. 430-437 | |
| dc.description | Markom, M., Hasan, M., Daud, W.R.W., Singh, H., Jahim, J.M., Extraction of hydrolysable tannins from Phyllanthus niruri Linn.: Effects of solvents and extraction methods (2007) Sep. Purif. Technol., 52, pp. 487-496 | |
| dc.description | Martins, L., Pereira-Filho, E., Cass, Q., Chromatographic profiles of Phyllanthus aqueous extracts samples: A proposition of classification using chemometric models (2011) Anal. Bioanal. Chem., 400, pp. 469-481 | |
| dc.description | Guha, G., Rajkumar, V., Ashok Kumar, R., Mathew, L., Aqueous extract of Phyllanthus amarus inhibits chromium(VI)-induced toxicity in MDA-MB-435S cells (2010) Food Chem. Toxicol., 48, pp. 396-401 | |
| dc.description | Miller, D.J., Hawthorne, S.B., Method for determining the solubilities of hydrophobic organics in subcritical water (1998) Anal. Chem., 70, pp. 1618-1621 | |
| dc.description | Yang, Y., Belghazi, M., Lagadec, A., Miller, D.J., Hawthorne, S.B., Elution of organic solutes from different polarity sorbents using subcritical water (1998) J. Chromatogr. A, 810, pp. 149-159 | |
| dc.description | Huang, R.-L., Huang, Y.-L., Ou, J.-C., Chen, C.-C., Hsu, F.-L., Chang, C., Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro (2003) Phyther. Res., 17, pp. 449-453 | |
| dc.description | Singh, M., Tiwari, N., Shanker, K., Verma, R.K., Gupta, A.K., Gupta, M.M., Two new lignans from Phyllanthus amarus (2009) J. Asian Nat. Prod. Res., 11, pp. 562-568 | |
| dc.description | Molska, G.R., Negri, G., Paula-Freire, L.I.G., Araujo, L.P., Kohn, D.O., Basso, A.S., Phyllanthus amarus does not affect hypernociception in experimental autoimmune encephalomyelitis (2014) Plant Med., pp. 277-282 | |
| dc.description | | |
| dc.description | | |
| dc.language | en | |
| dc.publisher | Elsevier | |
| dc.relation | Separation and Purification Technology | |
| dc.rights | fechado | |
| dc.source | Scopus | |
| dc.title | Extraction Of Lignans From Phyllanthus Amarus Schum. & Thonn Using Pressurized Liquids And Low Pressure Methods | |
| dc.type | Artículos de revistas | |
