Artículos de revistas
Associated Factors For Higher Lead And Cadmium Blood Levels, And Reference Values Derived From General Population Of São Paulo, Brazil
Registro en:
Science Of The Total Environment. Elsevier, v. 543, p. 628 - 635, 2016.
489697
10.1016/j.scitotenv.2015.11.067
2-s2.0-84947798319
Institución
Resumen
Human activities are associated with emissions of various metals into the environment, among which the heavy metals lead and cadmium stand out, as they pose a risk to human life even at low concentrations. Thus, accurate knowledge of the levels of these metals exhibited by the overall population, including children, is important. The aim of this study was to estimate the concentrations of lead and cadmium in the blood of adults, adolescents and children residing in the city of São Paulo, assess factors associated with higher lead and cadmium blood levels, and to establish reference values for this population. The study sample consisted of 669 adults over 20. years old, 264 adolescents aged 12 to 19. years old and 391 children under 11. years old from both genders. The samples were collected at the end of 2007 and during 2008 in different city zones. Higher blood lead concentration was significantly associated with gender, smoking, offal intake, area of residence and age. The blood cadmium concentration was significantly associated with gender, smoking, consumption of distilled beverages and age. The reference values of lead and cadmium established for adults above 20. years old were 33. μg/L and 0.6. μg/L, respectively, for adolescents (12 to 19. years old) were 31. μg/L and 0.6. μg/L, respectively and for children under 11. years old were 29. μg/L and 0.2. μg/L, respectively.The results of this study indicate that the exposure levels of the investigated population to lead and cadmium are low. © 2015 Elsevier B.V. 543
628 635 Alimonti, A., Bocca, B., Mannella, E., Petrucci, F., Zennaro, F., Cotichini, R., D'Ippolito, C., Forte, G., Assessment of reference values for selected elements in a health urban population (2005) Ann. Ist. Super. Sanita., 41, pp. 181-187 Angerer, J., Aylward, L.L., Hays, S.M., Heinzow, B., Wilhelm, M., Human biomonitoring assessment values: approaches and data requirements (2011) Int. J. Hyg. Environ. Health, 214, pp. 348-360 Apostoli, P., Elements in environmental and occupational medicine. Review (2002) J. Chromatogr. B, 778, pp. 63-97 (2007), http://www.atsdr.cdc.gov/toxprofiles/tp13.pdf, Toxicological Profile for Lead. Atlanta, GA: Agency for Toxic Substances and Disease Registry. Division of Toxicology and Environmental Medicine/Applied Toxicology Branch(2012), http://www.atsdr.cdc.gov/toxprofiles/tp5.pdf, Toxicological Profile for Cadmium. Atlanta, GA: Agency for Toxic Substances and Disease Registry. Division of Toxicology and Human Health Sciences, Environmental Toxicology BranchBatariová, A., Spevacková, V., Benes, B., Cejchanová, M., Smíd, J., Cerná, M., Blood and urine levels of Pb, Cd and Hg in the general population of the Czech Republic and proposed reference values (2006) Int. J. Hyg. Environ. Health, 209, pp. 359-366 Becker, K., Kaus, S., Krause, C., Lepom, P., Schulz, C., Seiwert, M., Seifert, B., German Environmental Survey 1998 (GerES III) environmental pollutants in blood of the German population (2002) Int. J. Environ. Health, 205, pp. 297-308 Bernard, A., Cadmium & its adverse effects on human health (2008) Indian J. Med. Res., 128, pp. 557-564 Birgisdottir, B.E., Knutsen, H.K., Haugen, M., Gjelstad, I.M., Jenssen, M.T.S., Ellingsen, D.G., Thomassen, Y., Brantsaeter, A.L., Essential and toxic element concentrations in blood and urine and their associations with diet: results from a Norwegian population study including high-consumers of seafood and game (2013) Sci. Total Environ., pp. 836-844 (2013), http://www.cdc.gov/exposurereport/pdf/FourthReport_UpdatedTables_Sep2013.pdf, Fourth National Report on Human Exposure to Environmental Chemicals. Updated tables. Atlanta, GA: Centers for Disease Control and PreventionCerná, M., Krsková, A., Cejchanová, M., Spevácková, V., Human biomonitoring in the Czech Republic: an overview (2012) Int. J. Hyg. Environ. Health, 215, pp. 109-119 Chasin, A.A.M., Cardoso, L.M.N., Cádmio (2003) Metais Gerenciamento da Toxicidade, pp. 263-298. , Editora Atheneu, São Paulo, F.A. Azevedo (Ed.) Ewers, U., Krause, C., Schulz, C., Wilhelm, M., Reference values and human biological monitoring values for environmental toxins (1999) Int. Arch. Occup. Environ. Health, 72, pp. 255-260 Forte, G., Madeddu, R., Tolu, P., Asara, Y., Marchal, J.A., Bocca, B., Reference intervals for blood Cd and Pb in the general population of Sardinia (Italy) (2011) Int. J. Hyg. Environ. Health, 214, pp. 102-109 He, P., Lu, Y., Liang, Y., Chen, B., Wu, M., Li, S., He, G., Jin, T., Exposure assessment of dietary cadmium: findings from Shanghainese over 40years, China (2013) BMC Public Health, 13, pp. 590-599 Heitland, P., Köster, H.D., Biomonitoring of 37 trace elements in blood samples from inhabitants of northern Germany by ICP-MS (2006) J. Trace Elem. Med. Biol., 20, pp. 253-262 Ikeda, M., Ohashi, F., Fukui, Y., Sakuragi, S., Moriguchi, J., Cadmium, chromium, lead, manganese and nickel concentrations in blood of women in non-polluted areas in Japan, as determined by inductively coupled plasma-sector field-mass spectrometry (2011) Int. Arch. Occup. Environ. Health, 84, pp. 139-150 Järup, L., Berglund, M., Elinder, C.G., Nordberg, G., Vahter, M., Health effects of cadmium exposure-a review of the literature and a risk estimate (1998) Scand. J. Work Environ. Health, 24, pp. 1-51 Karrari, P., Mehrpour, O., Abdollahi, M., A systematic review on status of lead pollution and toxicity in Iran guidance for preventive measures (2012) Daru, 20 (1), p. 2 Kim, N.-S., Lee, B.-K., National estimates of blood lead, cadmium, and mercury levels in the Korean general adult population (2011) Int. Arch. Occup. Environ. Health, 84, pp. 53-63 Kira, C.S., Sakuma, A.M., Gouveia, N.C., Fast and simple multi-element determination of essential and toxic metals in whole blood with quadrupole ICP-MS (2014) J. Appl. Pharm. Sci., 4 Korrich, S.A., Schwartz, J., Tsaih, S.-W., Hunter, D.J., Aro, A., Rosner, B., Speizer, F.E., Hu, H., Correlates of bone and blood lead levels among middle-aged and elderly women (2002) Am. J. Epidemiol., 156 (4), pp. 335-343 Koyashiki, G.A.K., Paoliello, M.M.B., Matsuo, T., de Oliveira, M.M.B., Mezzaroba, L., Carvalho, M.F., Sakuma, A.M., Barbosa, C.S.D., Lead levels in milk and blood from donors to the breast milk bank in Southern Brazil (2010) Environ. Res., 110, pp. 265-271 Kuno, R., Roquett, M.H., Becker, K., Seiwert, M., Gouveia, N., Reference values for lead, cadmium and mercury in the blood of adults from the metropolitan area of São Paulo, Brazil (2013) Int. J. Hyg. Environ. Health, 216, pp. 243-249 Lauwerys, R.R., Hoet, P., Biological monitoring of exposure to inorganic and organometallic substances (2001) Guidelines for Biological Monitoring, pp. 21-180. , CRC Press LLC, Boca Raton, FL, R.R. Lauwerys, P. Hoet (Eds.) Industrial Chemical Exposure Lee, B.-K., Kim, Y., Sex-specific profiles of blood metal levels associated with metal-iron interactions (2014) Saf. Health Works, 5, pp. 113-117 Link, B., Gabrio, T., Piechotowsk, I., Zllner, I., Schwenk, M., Baden-Wuerttemberg environmental health survey (BW-EHS) from 1996 to 2003: toxic metals in blood and urine of children (2007) Int. J. Environ. Health, 210, pp. 357-371 Liu, J., Yuan, E., Zhang, Z., Jia, L., Yin, Z., Meng, X., Du, H., Age and sex specific reference intervals for blood copper, zinc, calcium, magnesium, iron, lead and cadmium in infants and children (2012) Clin. Biochem., 45, pp. 416-419 Madeddu, R., Solinas, G., Forte, G., Bocca, B., Asara, Y., Tolu, P., Delogue, L.G., Castigliac, P., Diet and nutrients are contributing factors that influence blood cadmium levels (2011) Nutr. Res., 31, pp. 691-697 Mattos, R.C.O.C., Carvalho, M.A.R., Mainenti, H.R.D., Xavier Junior, E.C., Sarcinelli, P.N., Carvalho, L.B.V., Borges, R.M., Alves, M.F.M., Avaliação dos fatores de risco relacionados à exposição ao chumbo em crianças e adolescentes do Rio de Janeiro (2009) Cien Saude Colet, 14, pp. 2039-2048 McKelvey, W., Gwynn, C., Jeffery, N., Kass, D., Thorpe, L.E., Garg, R.K., Palmer, C.D., Parsons, P.J., A biomonitoring study of lead, cadmium, and mercury in the blood of New York city adults (2007) Environ. Health Perspect., 115, pp. 1435-1441 Mehmood, A., Sarfraz, R.A., Qudoos, A., Akbar, F., Appraisal of some heavy metals in organ meat from non-industrialized areas of Faisalabad, Pakistan (2014) Global Vet., 12, pp. 98-103 Menezes Filho, J.A., Viana, G.F.S., Paes, C.R., Determinants of lead exposure in children on the outskirts of Salvador, Brazil (2012) Environ. Monit. Assess., 184, pp. 2593-2603 Mijal, R.S., Holzman, C.B., Blood cadmium levels in women of childbearing age vary by race/ethnicity (2010) Environ. Res., 110, pp. 505-512 Minozzo, R., Minozzo, E.L., Deimling, L.I., Santos-Mello, R., Blood lead levels in the battery recycling industry of the metropolitan region of Porto Alegre, RS (2008) J. Bras. Patol. MedLab, 44, pp. 407-412 Nawrot, T.S., Staessen, J.A., Roels, H.A., Munters, E., Cuypers, A., Richart, T., Cadmium exposure in the population: from health risks to strategies of prevention (2010) Biometals, 23, pp. 769-782 Nordberg, M., Nordberg, G.F., Cadmium (2002) Heavy Metals in the Environment, pp. 231-270. , Marcel Dekker Inc., New York, B. Sarkar (Ed.) Nordberg, G.F., Nogawa, K., Nordberg, M., Friberg, L.T., Cadmium (2007) Handbook on the Toxicology of Metals, pp. 445-486. , Academic Press, California, G.F. Nordberg, B.A. Fowler, M. Nordberg, L.T. Friberg (Eds.) (2003), http://www.who.int/ifcs/documents/forums/forum5/nmr_cadmium.pdf, Cadmium review. Report n. 1, issue 4Nunes, J.A., Batista, B.L., Rodrigues, J.L., Caldas, N.M., Neto, J.A.G., Barbosa, J.F., A simple method based on ICP-MS for estimation of background levels of arsenic, cadmium, copper, manganese, nickel, lead, and selenium in blood of the Brazilian population (2010) J. Toxicol. Environ. Health Part A, 73, pp. 878-887 Obasohan, E.E., Heavy metals concentrations in the offal, gill, muscle and liver of a freshwater mudfish (Parachanna obscura) from Ogba River, Benin city, Nigeria (2007) Afr. J. Biotechnol., 6, pp. 2620-2627 Olsson, I.-M., Bensryd, I., Lundh, T., Ottosson, H., Skerfving, S., Oskarsson, A., Cadmium in blood and urine - impact of sex, age, dietary intake, iron status and former smoking - association of renal effects (2002) Environ. Health Perspect., 110, pp. 1185-1190 Paoliello, M.M.B., Chasin, A.M., (2001), Ecotoxicologia do chumbo e seus compostos. Série Cadernos de Referência Ambiental, v. 3. Salvador, Centro de Recursos AmbientaisPaoliello, M.M.B., Gutierrez, P.R., Turini, C.A., Matsuo, T., Mezzaroba, L., Barbosa, D.S., Carvalho, S.R.Q., Cascales, R.A., Valores de referência para plumbemia em uma população urbana do sul do Brasil (2001) Rev Panam Salud Publica/Pan. Am. J. Public Health, 9, pp. 315-319 Pawlas, N., Strmberg, U., Carlberg, B., Cerná, M., Harari, F., Harari, R., Horvat, M., Bergdhal, I., Cadmium, mercury and lead in the blood of urban women in Croatia, the Czech Republic, Poland, Slovakia, Slovenia, Sweden, China, Ecuador and Morocco (2013) Int. J. Occup. Med. Environ. Health, 26, pp. 58-72 Pino, A., Amato, A., Alimonti, A., Mattei, D., Bocca, B., Human biomonitoring for metals in Italian urban adolescents: data from Latium region (2012) Int. J. Hyg. Environ. Health, 215, pp. 185-190 Popovic, M., McNeill, F.E., Chettle, D.R., Webber, C.E., Lee, V., Kaye, W.E., Impact of occupational exposure on lead levels in women (2005) Environ. Health Perspect., 113, pp. 478-484 Pourmand, A., Al-tiae, T.K., Mazer-Amirshahi, M., Perspective on lead toxicity, a comparison between the United States and Iran (2012) Daru, 20 (70) Roggi, C., Sabbioni, E., Minoia, C., Ronchi, A., Gatti, A., Hansen, B., Silva, S., Maccarini, L., Trace element reference values in tissues from inhabitants of the European Union. IX. Harmonization of statistical treatment: blood cadmium in Italian subjects (1995) Sci. Total Environ., 166, pp. 235-243 (2011), SAS/STAT Guide for Personal Computers, Version 9.3. Cary, NC: SAS Institute, IncSchroijen, C., Baeyens, W., Schoeters, G., Hond, E.D., Koppen, G., Bruckers, L., Nelen, V., Van Larebeke, N., Internal exposure to pollutants measured in blood and urine of Flemish adolescents in function of area of residence (2008) Chemosphere, 71, pp. 1317-1325 Schulz, C., Angerer, J., Ewers, U., Heudorf, U., Wilhelm, M., Revised and new reference values for environmental pollutants in urine or blood of children in Germany derived from the German Environmental Survey on Children 2003-2006 (GerES IV) (2009) Int. J. Hyg. Environ. Health, 212, pp. 637-647 Schulz, C., Wilhelm, M., Heudorf, U., Kolossa-Gehring, M., Reprint of "update of the reference and HBM values derived by the German human biomonitoring commission" (2012) Int. J. Hyg. Environ. Health, 215, pp. 150-158 Skerfving, S., Bergdahl, I.A., Lead (2007) Handbook on the Toxicology of Metals, pp. 599-643. , Academic Press, [s.l.], G.F. Nordberg, B.A. Fowler, M. Nordberg, L. Friberg (Eds.) Skerfving, S., Becko, V., Vahter, M., Schütz, A., Gerhardsson, L., Environmental health in the Baltic region - toxic metals (1999) Scand. J. Work Environ. Health, 25, pp. 40-64 Solberg, H.E., Approved recommendation (1986) on the theory of reference values. Part 1. The concept of reference values (1987) Clin. Chim. Acta, 165, pp. 111-118 Son, J.-Y., Lee, J., Paek, D., Lee, J.-T., Blood levels of lead, cadmium, and mercury in the Korean population: results from the Second Korean National Human Exposure and Bio-monitoring Examination (2009) Environ. Res., 109, pp. 738-744 Valavanidis, A., Vlachogianni, T., Metal pollution in ecosystems. Ecotoxicology studies and risks assessment in the marine environment (2010) Science Advances on Environment, Toxicology and Ecotoxicology Issues, , http://chem-tox-ecotox.org/wp/wp-content/uploads/2010/01/02-Metals-17-01-2010.pdf White, M.A., Sabbioni, E., Trace element reference values in tissues from inhabitants of the European Union. X. A study of 13 elements in blood and urine of a United Kingdom population (1998) Sci. Total Environ., 216, pp. 253-270 (1977), http://www.inchem.org/documents/ehc/ehc/ehc003.htm, Lead. Environmental Health Criteria 3. World Health Organization. International Programme on Chemical Safety (IPCS), Geneva, Switzerland: World Health Organization(1992), http://www.inchem.org/documents/ehc/ehc/ehc135.htm, Cadmium - environmental aspects. Environmental Health Criteria 135. World Health Organization, International Programme on Chemical Safety (IPCS), Geneva, Switzerland: World Health Organization(1995), http://www.inchem.org/documents/ehc/ehc/ehc165.htm, Inorganic lead. Environmental Health Criteria 165. World Health Organization, International Programme on Chemical Safety (ICPS), Geneva, Switzerland: World Health OrganizationWilhelm, M., Ewers, U., Schulz, C., Revised and new reference values for some trace elements in blood and urine for human biomonitoring in environmental medicine (2004) Int. J. Hyg. Environ. Health, 207, pp. 69-73