Comparative Study Between Fast And Slow Induction Of Propofol Given By Target-controlled Infusion: Expected Propofol Concentration At The Effect Site: Randomized Controlled Trial [estudo Comparativo Entre Indução Rápida E Lenta De Propofol Em Infusão Alvo-controlada: Concentração De Propofol Prevista No Local De Ação: Ensaio Clínico Aleatório]

dc.date2015
dc.date2016-06-03T20:14:56Z
dc.date2016-06-03T20:14:56Z
dc.date.accessioned2018-03-29T01:33:37Z
dc.date.available2018-03-29T01:33:37Z
dc.identifier
dc.identifierRevista Brasileira De Anestesiologia. Elsevier Editora Ltda, v. 65, n. 2, p. 99 - 103, 2015.
dc.identifier347094
dc.identifier10.1016/j.bjan.2013.07.015
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84922780118&partnerID=40&md5=f18db21c78e34a1c9dc938e24bea01b4
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/238302
dc.identifier2-s2.0-84922780118
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1304963
dc.descriptionBackground and objective: studies have shown that rate of propofol infusion may influence the predicted propofol concentration at the effect site (Es). The aim of this study was to evaluate the Es predicted by the Marsh pharmacokinetic model (ke0 0.26min-1) in loss of consciousness during fast or slow induction. Method: the study included 28 patients randomly divided into two equal groups. In slow induction group (S), target-controlled infusion (TCI) of propofol with plasma, Marsh pharmacokinetic model (ke0 0.26min-1) with target concentration (Tc) at 2.0-μg.mL-1 were administered. When the predicted propofol concentration at the effect site (Es) reached half of Es value, Es was increased to previous Es + 1μg.mL-1, successively, until loss of consciousness. In rapid induction group (R), patients were induced with TCI of propofol with plasma (6.0μg.ml-1) at Es, and waited until loss of consciousness. Results: in rapid induction group, Tc for loss of consciousness was significantly lower compared to slow induction group (1.67±0.76 and 2.50±0.56μg.mL-1, respectively, p=0.004). Conclusion: the predicted propofol concentration at the effect site for loss of consciousness is different for rapid induction and slow induction, even with the same pharmacokinetic model of propofol and the same balance constant between plasma and effect site. © 2014 Sociedade Brasileira de Anestesiologia.
dc.description65
dc.description2
dc.description99
dc.description103
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dc.description
dc.description
dc.languagept
dc.publisherElsevier Editora Ltda
dc.relationRevista Brasileira de Anestesiologia
dc.rightsfechado
dc.sourceScopus
dc.titleComparative Study Between Fast And Slow Induction Of Propofol Given By Target-controlled Infusion: Expected Propofol Concentration At The Effect Site: Randomized Controlled Trial [estudo Comparativo Entre Indução Rápida E Lenta De Propofol Em Infusão Alvo-controlada: Concentração De Propofol Prevista No Local De Ação: Ensaio Clínico Aleatório]
dc.typeArtículos de revistas


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