| dc.date | 2015 | |
| dc.date | 2016-06-03T20:13:19Z | |
| dc.date | 2016-06-03T20:13:19Z | |
| dc.date.accessioned | 2018-03-29T01:32:27Z | |
| dc.date.available | 2018-03-29T01:32:27Z | |
| dc.identifier | | |
| dc.identifier | Journal Of Functional Foods. Elsevier Ltd, v. 19, p. 464 - 478, 2015. | |
| dc.identifier | 17564646 | |
| dc.identifier | 10.1016/j.jff.2015.09.009 | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84946415398&partnerID=40&md5=364773f0232c441cc087262d97d5bf31 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/238021 | |
| dc.identifier | 2-s2.0-84946415398 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1304682 | |
| dc.description | Propolis has documented anti-inflammatory properties, although its mechanisms of action are poorly understood. In this study, the anti-inflammatory effects of polyphenol-rich propolis extracts (PPE) from China (CPPE) and Brazil (BPPE) were examined. Oral administration of PPE to lipopolysaccharide (LPS)-challenged mice decreased serum proinflammatory cytokine concentrations and inhibited pulmonary nuclear factor (NF)-κB activation. Both PPE types modulated LPS-induced key inflammatory mediators production in RAW 264.7 macrophages. They also suppressed NF-κB activation in HEK 293T cells, correlating well with their inhibitory effects on IκB phosphorylation and p65 nuclear translocation in LPS-activated macrophages. We found PPE suppressed NF-κB activation through delaying the ubiquitination of TRAF6 in HeLa-T6RZC stable cells and by directly disrupting the polyubiquitin synthesis in an in vitro kinase assay system. Overall, analysis showed substantial compositional differences between CPPE and BPPE; nevertheless, they both displayed similar anti-inflammatory properties through NF-κB-responsive inflammatory gene expressions by inhibiting TRAF6 dependent canonical NF-κB pathway. © 2015 Elsevier Ltd. | |
| dc.description | 19 | |
| dc.description | | |
| dc.description | 464 | |
| dc.description | 478 | |
| dc.description | Baker, R.G., Hayden, M.S., Ghosh, S., NF-κB, inflammation, and metabolic disease (2011) Cell Metabolism, 13 (1), pp. 11-22 | |
| dc.description | Bankova, V., Chemical diversity of propolis and the problem of standardization (2005) Journal of Ethnopharmacology, 100 (1-2), pp. 114-117 | |
| dc.description | Berbaum, K., Shanmugam, K., Stuchbury, G., Wiede, F., Korner, H., Munch, G., Induction of novel cytokines and chemokines by advanced glycation endproducts determined with a cytometric bead array (2008) Cytokine, 41 (3), pp. 198-203 | |
| dc.description | Bueno-Silva, B., Alencar, S.M., Koo, H., Ikegaki, M., Silva, G.V., Napimoga, M.H., Rosalen, P.L., Anti-inflammatory and antimicrobial evaluation of neovestitol and vestitol isolated from Brazilian red propolis (2013) Journal of Agricultural and Food Chemistry, 61 (19), pp. 4546-4550 | |
| dc.description | Bufalo, M.C., Ferreira, I., Costa, G., Francisco, V., Liberal, J., Cruz, M.T., Lopes, M.C., Sforcin, J.M., Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-kappaB and MAPK activation in macrophages (2013) Journal of Ethnopharmacology, 149 (1), pp. 84-92 | |
| dc.description | Chan, G.C.-F., Cheung, K.-W., Sze, D.M.-Y., The immunomodulatory and anticancer properties of propolis (2013) Clinical Reviews in Allergy & Immunology, 44 (3), pp. 262-273 | |
| dc.description | Chawla, A., Nguyen, K.D., Goh, Y.S., Macrophage-mediated inflammation in metabolic disease (2011) Nature Reviews. Immunology, 11 (11), pp. 738-749 | |
| dc.description | Cuevas, A., Saavedra, N., Cavalcante, M.F., Salazar, L.A., Abdalla, D.S.P., Identification of microRNAs involved in the modulation of pro-angiogenic factors in atherosclerosis by a polyphenol-rich extract from propolis (2014) Archives of Biochemistry and Biophysics, 557 (1), pp. 28-35 | |
| dc.description | Daleprane, J.B., Freitas Vda, S., Pacheco, A., Rudnicki, M., Faine, L.A., Dorr, F.A., Ikegaki, M., Abdalla, D.S., Anti-atherogenic and anti-angiogenic activities of polyphenols from propolis (2012) Journal of Nutritional Biochemistry, 23 (6), pp. 557-566 | |
| dc.description | Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Chen, Z.J., Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain (2000) Cell, 103 (2), pp. 351-361 | |
| dc.description | dos Santos, J.S., Monte-Alto-Costa, A., Caffeic acid phenethyl ester improves burn healing in rats through anti-inflammatory and antioxidant effects (2013) Journal of Burn Care & Research, 34 (6), pp. 682-688 | |
| dc.description | Haque, A., Koide, N., Noman, A.S.M., Odkhuu, E., Badamtseren, B., Naiki, Y., Komatsu, T., Yokochi, T., Flavopiridol inhibits lipopolysaccharide-induced TNF-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway (2011) Microbiology and Immunology, 55 (3), pp. 160-167 | |
| dc.description | Hämäläinen, M., Nieminen, R., Vuorela, P., Heinonen, M., Moilanen, E., Anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κ B activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κ B activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages (2007) Mediators of Inflammation, , 2007:45673 | |
| dc.description | Hervert-Hernández, D., Goñi, I., Dietary polyphenols and human gut microbiota: A review (2011) Food Reviews International, 27 (2), pp. 154-169 | |
| dc.description | Hou, J., Wang, J., Zhang, P., Li, D., Zhang, C., Zhao, H., Fu, J., Liu, J., Baicalin attenuates proinflammatory cytokine production in oxygen-glucose deprived challenged rat microglial cells by inhibiting TLR4 signaling pathway (2012) International Immunopharmacology, 14 (4), pp. 749-757 | |
| dc.description | Hougee, S., Sanders, A., Faber, J., Graus, Y.M., van den Berg, W.B., Garssen, J., Smit, H.F., Hoijer, M.A., Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages (2005) Biochemical Pharmacology, 69 (2), pp. 241-248 | |
| dc.description | Hu, F., Hepburn, H.R., Li, Y., Chen, M., Radloff, S.E., Daya, S., Effects of ethanol and water extracts of propolis (bee glue) on acute inflammatory animal models (2005) Journal of Ethnopharmacology, 100 (3), pp. 276-283 | |
| dc.description | Jakus, P.B., Kalman, N., Antus, C., Radnai, B., Tucsek, Z., Gallyas, F., Sumegi, B., Veres, B., TRAF6 is functional in inhibition of TLR4-mediated NF-κB activation by resveratrol (2013) Journal of Nutritional Biochemistry, 24 (5), pp. 819-823 | |
| dc.description | Joseph, S.V., Edirisinghe, I., Burton-Freeman, B.M., Fruit polyphenols: A review of anti-inflammatory effects in humans (2015) Critical Reviews in Food Science and Nutrition | |
| dc.description | Jung, Y.C., Kim, M.E., Yoon, J.H., Park, P.R., Youn, H.-Y., Lee, H.-W., Lee, J.S., Anti-inflammatory effects of galangin on lipopolysaccharide-activated macrophages via ERK and NF-κB pathway regulation (2014) Immunopharmacology and Immunotoxicology, 36 (6), pp. 426-432 | |
| dc.description | Koeberle, A., Werz, O., Multi-target approach for natural products in inflammation (2014) Drug Discovery Today, 19 (12), pp. 1871-1882 | |
| dc.description | Lamothe, B., Besse, A., Campos, A.D., Webster, W.K., Wu, H., Darnay, B.G., Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of IκB kinase activation (2007) Journal of Biological Chemistry, 282 (6), pp. 4102-4112 | |
| dc.description | Machado, J.L., Assunção, A.K., da Silva, M.C., Dos Reis, A.S., Costa, G.C., Arruda Dde, S., Rocha, B.A., do Nascimento, F.R., Brazilian green propolis: Anti-inflammatory property by an immunomodulatory activity (2012) Evidence-based Complementary and Alternative Medicine | |
| dc.description | Martinez, F.O., Sica, A., Mantovani, A., Locati, M., Macrophage activation and polarization (2007) Frontiers in Bioscience, 13, pp. 453-461 | |
| dc.description | Muschietti, L., Gorzalczany, S., Ferraro, G., Acevedo, C., Martino, V., Phenolic compounds with anti-inflammatory activity from Eupatorium buniifolium (2001) Planta Medica, 67 (743), pp. 743-744 | |
| dc.description | Natarajan, K., Singh, S., Burke, T.R., Grunberger, D., Aggarwal, B.B., Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B (1996) Proceedings of the National Academy of Sciences, 93 (17), pp. 9090-9095 | |
| dc.description | Nicholas, C., Batra, S., Vargo, M.A., Voss, O.H., Gavrilin, M.A., Wewers, M.D., Guttridge, D.C., Doseff, A.I., Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation (2007) The Journal of Immunology, 179 (10), pp. 7121-7127 | |
| dc.description | Nishihira, J., Sato-Ueshima, M., Kitadate, K., Wakame, K., Fujii, H., Amelioration of abdominal obesity by low-molecular-weight polyphenol (Oligonol) from lychee (2009) Journal of Functional Foods, 1 (4), pp. 341-348 | |
| dc.description | Okamoto, Y., Hara, T., Ebato, T., Fukui, T., Masuzawa, T., Brazilian propolis ameliorates trinitrobenzene sulfonic acid-induced colitis in mice by inhibiting Th1 differentiation (2013) International Immunopharmacology, 16 (2), pp. 178-183 | |
| dc.description | Orsatti, C.L., Missima, F., Pagliarone, A.C., Sforcin, J.M., Th1/Th2 cytokines' expression and production by propolis-treated mice (2010) Journal of Ethnopharmacology, 129 (3), pp. 314-318 | |
| dc.description | Park, Y.K., Paredes-Guzman, J.F., Aguiar, C.L., Alencar, S.M., Fujiwara, F.Y., Chemical constituents in Baccharis dracunculifolia as the main botanical origin of southeastern Brazilian propolis (2004) Journal of Agricultural and Food Chemistry, 52 (5), pp. 1100-1103 | |
| dc.description | Paulino, N., Abreu, S.R.L., Uto, Y., Koyama, D., Nagasawa, H., Hori, H., Dirsch, V.M., Bretz, W.A., Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis (2008) European Journal of Pharmacology, 587 (1), pp. 296-301 | |
| dc.description | Petroski, M.D., Zhou, X., Dong, G., Daniel-Issakani, S., Payan, D.G., Huang, J., Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme (2007) Journal of Biological Chemistry, 282 (41), pp. 29936-29945 | |
| dc.description | Sawaya, A., Cunha, I., Marcucci, M.C., Analytical methods applied to diverse types of Brazilian propolis (2011) Chemistry Central Journal, 5 (1), p. 27 | |
| dc.description | Sforcin, J.M., Bankova, V., Propolis: Is there a potential for the development of new drugs? (2011) Journal of Ethnopharmacology, 133 (2), pp. 253-260 | |
| dc.description | Shahidi, F., Ambigaipalan, P., Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects - A review (2015) Journal of Functional Foods, 2015. , In press | |
| dc.description | Shi, H., Yang, H., Zhang, X., Yu, L., Identification and quantification of phytochemical composition and anti-inflammatory and radical scavenging properties of methanolic extracts of Chinese propolis (2012) Journal of Agricultural and Food Chemistry, 60 (50), pp. 12403-12410 | |
| dc.description | Shigeshiro, M., Tanabe, S., Suzuki, T., Dietary polyphenols modulate intestinal barrier defects and inflammation in a murine model of colitis (2013) Journal of Functional Foods, 5 (2), pp. 949-955 | |
| dc.description | Szliszka, E., Mertas, A., Czuba, Z.P., Krol, W., Inhibition of inflammatory response by artepillin C in activated RAW264.7 macrophages (2013) Evidence-based Complementary and Alternative Medicine, 2013, p. 735176 | |
| dc.description | Toreti, V.C., Sato, H.H., Pastore, G.M., Park, Y.K., Recent progress of propolis for its biological and chemical compositions and its botanical origin (2013) Evidence-based Complementary and Alternative Medicine, 2013, p. 697390 | |
| dc.description | Wang, C., Deng, L., Hong, M., Akkaraju, G.R., Inoue, J., Chen, Z.J., TAK1 is a ubiquitin-dependent kinase of MKK and IKK (2001) Nature, 412 (6844), pp. 346-351 | |
| dc.description | Wang, K., Ping, S., Huang, S., Hu, L., Xuan, H., Zhang, C., Hu, F., Molecular mechanisms underlying the in vitro anti-inflammatory effects of a flavonoid-rich ethanol extract from Chinese propolis (poplar type) (2013) Evidence-based Complementary and Alternative Medicine, 2013, p. 127672 | |
| dc.description | Wang, K., Zhang, J., Ping, S., Ma, Q.X., Chen, X., Xuan, H., Shi, J., Hu, F., Anti-inflammatory effects of ethanol extracts of Chinese propolis and buds from poplar (Populus×canadensis) (2014) Journal of Ethnopharmacology, 155 (1), pp. 300-311 | |
| dc.description | Wang, S., Moustaid-Moussa, N., Mo, H., Shastri, A., Su, R., Bapat, P., Kwun, I., Shen, C., Novel insights of dietary polyphenols and obesity (2014) Journal of Nutritional Biochemistry, 25 (1), pp. 1-18 | |
| dc.description | Xia, M.Z., Liang, Y.L., Wang, H., Chen, X., Huang, Y.Y., Zhang, Z.H., Chen, Y.H., Xu, D.X., Melatonin modulates TLR4-mediated inflammatory genes through MyD88-and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264. 7 cells (2012) Journal of Pineal Research, 53 (4), pp. 325-334 | |
| dc.description | Xuan, H., Zhao, J., Miao, J., Li, Y., Chu, Y., Hu, F., Effect of Brazilian propolis on human umbilical vein endothelial cell apoptosis (2011) Food and Chemical Toxicology, 49 (1), pp. 78-85 | |
| dc.description | Yin, Q., Lin, S.-C., Lamothe, B., Lu, M., Lo, Y.-C., Hura, G., Zheng, L., Myszka, D.G., E2 interaction and dimerization in the crystal structure of TRAF6 (2009) Nature Structural & Molecular Biology, 16 (6), pp. 658-666 | |
| dc.description | Zhang, J., Cao, X., Ping, S., Wang, K., Shi, J., Zhang, C., Zheng, H., Hu, F., Comparisons of ethanol extracts of Chinese propolis (poplar type) and poplar gums based on the antioxidant activities and molecular mechanism (2015) Evidence-based Complementary and Alternative Medicine | |
| dc.description | | |
| dc.description | | |
| dc.language | en | |
| dc.publisher | Elsevier Ltd | |
| dc.relation | Journal of Functional Foods | |
| dc.rights | fechado | |
| dc.source | Scopus | |
| dc.title | Polyphenol-rich Propolis Extracts From China And Brazil Exert Anti-inflammatory Effects By Modulating Ubiquitination Of Traf6 During The Activation Of Nf-κb | |
| dc.type | Artículos de revistas | |
