| dc.date | 2016 | |
| dc.date | 2016-06-03T20:12:39Z | |
| dc.date | 2016-06-03T20:12:39Z | |
| dc.date.accessioned | 2018-03-29T01:31:50Z | |
| dc.date.available | 2018-03-29T01:31:50Z | |
| dc.identifier | | |
| dc.identifier | Environmental And Molecular Mutagenesis. John Wiley And Sons Inc., v. 57, n. 1, p. 41 - 50, 2016. | |
| dc.identifier | 8936692 | |
| dc.identifier | 10.1002/em.21970 | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84954365259&partnerID=40&md5=cfe303eaf32d7c4c09e0397c41678190 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/237872 | |
| dc.identifier | 2-s2.0-84954365259 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1304533 | |
| dc.description | Atmospheric particulate matter (PM) is genotoxic and recently was classified as carcinogenic to humans by the International Agency for Research on Cancer. PM chemical composition varies depending on source and atmospheric conditions. The Salmonella/microsome assay is the most used mutagenicity test and can identify the major chemical classes responsible for observed mutagenicity. The objective of this work was to characterize the mutagenicity of PM samples from a countryside city, Limeira, Brazil, which is influenced by heavy traffic and sugar cane biomass burning. Six samples of total PM were collected. Air mass backward trajectories were calculated. Organic extracts were assayed using the Salmonella/microsome microsuspension mutagenicity assay using TA98, YG1041, and TA1538, with and without metabolic activation (S9). YG1041 was the most sensitive strain and mutagenicity reached 9,700 revertants per m3 without metabolic activation. Potency for TA1538 was higher than TA98, indicating that this strain should be considered in air mutagenicity studies. The increased response to YG1041 relative to TA98, and the decreased response with S9, suggests that nitroaromatics are the major contributors. Limeira is among the most mutagenic cities in the world. High mutagenicity in Limeira seems to occur when the air mass from the area of sugarcane production is mixed with air from the region impacted by anthropogenic activities such as traffic. An increase in the formation of nitro-polycyclic aromatic hydrocarbons may result from longer contact time between the aromatic compounds and the atmosphere with high NOx and ozone concentration, although more studies are required to confirm this hypothesis. © 2016 Wiley Periodicals, Inc. | |
| dc.description | 57 | |
| dc.description | 1 | |
| dc.description | 41 | |
| dc.description | 50 | |
| dc.description | Adonis, M., Gil, L., Mutagenicity of organic extracts from Santiago (Chile) airborne particulate matter (1993) Mutat Res, 292, pp. 51-61 | |
| dc.description | Allen, A.G., Cardoso, A.A., Da Rocha, G.O., Influence of sugar cane burning on aerosol soluble ion composition in Southeastern Brazil (2004) Atmos Environ, 38, pp. 5025-5038 | |
| dc.description | Andrade, S.J., Cristale, J., Silva, F.S., Zocolo, G.J., Marchi, M.R.R., Contribution of sugar-cane harvesting season to atmospheric contamination by polycyclic aromatic hydrocarbons (PAHs) in Araraquara city, Southeast Brazil (2010) Atmos Environ, 44, pp. 2913-2919 | |
| dc.description | Andrade, S.J., Varella, S.D., Pereira, G.T., Zocolo, G.J., Marchi, M.R.R., Varanda, E.A., Mutagenic activity of airborne particulate matter (PM10) in a sugarcane farming area (Araraquara city, southeast Brazil) (2011) Environ Res, 111, pp. 545-550 | |
| dc.description | Atkinson, R., Gas-phase tropospheric chemistry of organic compound: A review (1990) Atmos Environ, 24, pp. 1-41 | |
| dc.description | Atkinson, R., Arey, J., Atmospheric chemistry of gas-phase polycyclic aromatic hydrocarbons: Formation of atmospheric mutagens (1994) Environ Health Perpect, 102, pp. 117-126 | |
| dc.description | Belcik, M., Trusz-Zdybek, A., Galas, E., Piekarska, K., Mutagenicity of organic pollutants adsorbed on suspended particulate matter in the center of Wroclaw (Poland) (2014) Atmos Environ, 95, pp. 620-628 | |
| dc.description | Bernstein, L., Kaldor, J., McCann, J., Pike, M.C., An empirical approach to the statistical analysis of mutagenesis data from the Salmonella test (1982) Mutat Res, 97, pp. 267-287 | |
| dc.description | Caetano, S.L., Allen, A.G., Lima, S.M., Cardoso, A.A., Campos, M.L.A.M., Nogueira, R.F.P., An analysis of diurnal cycles in the mass of ambient aerosols derived from biomass burning and agro-industry (2013) J Geophys Res Atmos, 118, pp. 8675-8687 | |
| dc.description | Carvalho, L.R.F., Fernandes, K.G., Allen, A.G., Cardoso, A.A., Diurnal and nocturnal measurements of PAH, nitro-PAH, and oxy-PAH compounds in atmospheric particulate matter of a sugar cane burning region (2014) Atmos Environ, 83, pp. 193-201 | |
| dc.description | Cavanagh, J.-A., Trought, K., Brown, L., Duggan, S., Exploratory investigation of the chemical characteristics and relative toxicity of ambient air particulates from two New Zealand cities (2009) Sci Total Environ, 407, pp. 5007-5018 | |
| dc.description | Cerná, M., Pastorková, A., Vrbíková, V., Smíd, J., Rössner, P., Mutagenicity monitoring of airborne particulate matter (PM10) in the Czech Republic (1999) Mutat Res, 444, pp. 373-386 | |
| dc.description | (2011) Relatório de Qualidade do Ar no Estado de São Paulo 2010, , São Paulo: Secretaria de Estado do Meio Ambiente | |
| dc.description | Claxton, L.D., Woodall, G.M., Jr., A review of the mutagenicity and rodent carcinogenicity of ambient air (2007) Mutat Res, 636, pp. 36-94 | |
| dc.description | Claxton, L.D., Warren, S., Zweidinger, R., Creason, J., A comparative assessment of Boise, Idaho, ambient air fine particle samples using the plate and microsuspension Salmonella mutagenicity assays (2001) Sci Total Environ, 275, pp. 95-108 | |
| dc.description | Claxton, L.D., Matthews, P.P., Warren, S.H., The genotoxicity of ambient outdoor air, a review: Salmonella mutagenicity (2004) Mutat Res, 567, pp. 347-399 | |
| dc.description | Claxton, L.D., Umbuzeiro, G.A., DeMarini, D.M., The Salmonella mutagenicity assay: The stethoscope of genetic toxicology for the 21st Century (2010) Environ Health Perspect, 118, pp. 1515-1522 | |
| dc.description | Coronado, C.R., Carvalho, J.J.A., Silveira, J.L., Biodiesel CO2 emissions: A comparison with the main fuels in the Brazilian Market (2009) Fuel Process Technol, 90, pp. 204-211 | |
| dc.description | Coronas, M.V., Horn, R.C., Ducatti, A., Rocha, J.V., Vargas, V.M., Mutagenic activity of airborne particulate matter in a petrochemical industrial area (2008) Mutat Res, 650, pp. 196-201 | |
| dc.description | Coronas, M.V., Pereira, T.S., Rocha, J.A., Lemos, A.T., Fachel, J.M., Salvadori, D.M., Vargas, V.M., Genetic biomonitoring of an urban population exposed to mutagenic airborne pollutants (2009) Environ Int, 35, pp. 1023-1029 | |
| dc.description | Cristale, J., Silva, F.S., Zocolo, G.J., Marchi, M.R.R., Influence of sugarcane burning on indoor/outdoor PAH air pollution in Brazil (2012) Environ Pollut, 169, pp. 210-216 | |
| dc.description | Daisey, J.M., Kneip, T.J., Hawryluk, I., Mukai, F., Seasonal variations in the bacterial mutagenicity of airborne particulate organic matter in New York City (1980) Environ Sci Technol, 14, pp. 1487-1490 | |
| dc.description | DeMarini, D.M., Declaring the existence of human germ-cell mutagens (2012) Environ Mol Mutagen, 53, pp. 166-172 | |
| dc.description | DeMarini, D.M., Dallas, M.M., Lewtas, J., Cytotoxicity and effect on mutagenicity of buffers in a microsuspension assay (1989) Teratog Carcinog Mutagen, 9, pp. 287-295 | |
| dc.description | DeMarini, D.M., Brooks, L.R., Warren, S.H., Kobayashi, T., Gilmour, M.I., Singh, P., Bioassay-directed fractionation and Salmonella mutagenicity of automobile and forklift diesel exhaust particles (2004) Environ Health Perspect, 112, pp. 814-819 | |
| dc.description | De Martinis, B.S., Kado, N.Y., Carvalho, L.R., Okamoto, R.A., Gundel, L.A., Genotoxicity of fractionated organic material in airborne particles from São Paulo, Brazil (1999) Mutat Res, 446, pp. 83-94 | |
| dc.description | Draxler, R.R., Rolph, G.D., (2015) HYSPLIT (HYbrid Single-Particle Lagrangian Integrated Trajectory) Model access via NOAA ARL READY Website, , http://www.arl.noaa.gov/HYSPLIT.php, College Park, MD: NOAA Air Resources Laboratory. Available at:. Accessed on May 10, 2015 | |
| dc.description | Ducatti, A., Vargas, V.M.F., Mutagenic activity of airborne particulate matter as an indicative measure of air pollution (2003) Mutat Res, 540, pp. 67-77 | |
| dc.description | Franco, A., Kummrow, F., Umbuzeiro, G.A., Vasconcellos, P.C., Carvalho, L.R.F., Occurrence of polycyclic aromatic hydrocarbons derivatives and mutagenicity study in extracts of PM10 collected in São Paulo, Brazil (2010) Rev Bras Toxicol, 23, pp. 1-10 | |
| dc.description | Hagiwara, Y., Watanabe, M., Oda, Y., Sofuni, T., Nohmi, T., Specificity and sensitivity of Salmonella typhimurium YG1041 and YG1042 strains possessing elevated levels of both nitroreductase and acetyltransferase activity (1993) Mutat Res, 291, pp. 171-180 | |
| dc.description | Hamra, G.B., Guha, N., Cohen, A., Laden, F., Raaschou-Nielsen, O., Samet, J.M., Vineis, P., Loomis, D., Outdoor particulate matter exposure and lung cancer: A systematic review and meta-analysis (2014) Environ Health Perspect, 122, pp. 906-911 | |
| dc.description | Herbold, B.A., Preliminary data from an international survey on the sensitivity of Ames tester strains (1982) Mutat Res, 97, pp. 191-192 | |
| dc.description | Rio de Janeiro: Instituto Brasileiro de Geografia e Estatística (IBGE) (2011) Levantamento Sistemático da Produção Agrícola | |
| dc.description | Cidades: São Paulo, Limeira - Infográficos: dados gerais do município (2015), http://www.cidades.ibge.gov.br/painel/painel.php?lang=&codmun=352690&search=%7C%7Cinfogr%E1ficos, dados- gerais-do-munic%EDpio. Accessed on May 2, 2015Queimadas (2015) Monitoramento de focos, , http://www.dpi.inpe.br/proarco/bdqueimadas/, Accessed on May 12, 2015 | |
| dc.description | Sistema de Informações Geográficas Aplicadas ao Meio Ambiente (2015), http://sigma.cptec.inpe.br:8080/produto/queimadas/queimadas/perguntas.html, Accessed on June 5, 2015Kado, N.Y., Langley, D., Eisenstatd, E., A simple modification of the Salmonella liquid incubation assay (1983) Mutat Res, 121, pp. 25-32 | |
| dc.description | Kado, N.Y., Guirguis, G.N., Flessel, C.P., Chan, R.C., Chang, K.I., Wesolowski, J.J., Mutagenicity of fine (less than 2.5 microns) airborne particles: Diurnal variation in community air determined by a Salmonella micro preincubation (microsuspension) procedure (1986) Environ Mutagen, 8, pp. 53-66 | |
| dc.description | Lewtas, J., Air pollution combustion emissions: Characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects (2007) Mutat Res, 636, pp. 95-133 | |
| dc.description | Löfroth, G., Stensman, C., Brandhorst-Satzkorn, M., Indoor sources of mutagenic aerosol particulate matter: Smoking, cooking and incense burning (1991) Mutat Res, 261, pp. 21-28 | |
| dc.description | Machado, C.M.D., Allen, A.G., Cardoso, A.A., Atmospheric emission of reactive nitrogen during biofuel production of ethanol (2008) Environ Sci Technol, 42, pp. 381-385 | |
| dc.description | Maron, D.M., Ames, B.N., Revised methods for the Salmonella mutagenicity test (1983) Mutat Res, 113, pp. 173-215 | |
| dc.description | Maruoka, S., Yamanaka, S., Mutagenicity in Salmonella typhimurium tester strains of XAD-2-ether extract, recovered from Katsura River water in Kyoto City, and its fractions (1982) Mutat Res, 102, pp. 13-26 | |
| dc.description | McCann, J., Spingarn, N.E., Kobori, J., Ames, B.N., Detection of carcinogens as mutagens: Bacterial tester strains with R Factor Plasmids (1975) Proc Natl Acad Sci USA, 72, pp. 979-983 | |
| dc.description | Medeiros, M.A., Froio, L., Actors, interests and strategies of Brazilian foreign policy on biofuels (2012) Bpsr, 6, pp. 37-52 | |
| dc.description | Middleton, R.W., Wibberley, D.G., Klemperer, R.M.M., The mutagenicity of some novel phenyl-imidazopyridines (1980) Mutat Res, 78, pp. 323-329 | |
| dc.description | Monarca, S., Crebelli, R., Feretti, D., Zanardini, A., Fuselli, S., Filini, L., Resola, S., Nardi, G., Mutagens and carcinogens in size-classified air particulates of a Northern Italian town (1997) Sci Total Environ, 205, pp. 137-144 | |
| dc.description | Mortelmans, K.E., Effect of R Plasmids on Salmonella typhimurium: UV-Killing, UV-Mutagenesis, and Spontaneous Mutability (1975), Ph.D. Thesis. Stanford UniversityMortelmans, K.E., Stocker, B.A.D., Ultraviolet light protection, enhancement of ultraviolet mutagenesis, and mutator effect of plasmid R46 in Salmonella typhimurium (1976) J Bacteriol, 128, pp. 271-282 | |
| dc.description | Mortelmans, K., Zeiger, E., The Ames Salmonella/microsome mutagenicity assay (2000) Mutat Res, 455, pp. 29-60 | |
| dc.description | Mugica-Alvarez, V., Santiago-de la Rosa, N., Figueroa-Lara, J., Flores-Rodríguez, J., Torres-Rodríguez, M., Magaña-Reyes, M., Emissions of PAHs derived from sugarcane burning and processing in Chiapas and Morelos México (2015) Sci Total Environ, pp. 474-482. , 527528 | |
| dc.description | Mutlu, E., Warren, S.H., Matthews, P.P., King, C., Linak, W.P., Kooter, I.M., Schmid, J.E., DeMarini, D.M., Bioassay-directed fractionation and sub-fractionation for mutagenicity and chemical analysis of diesel exhaust particles (2013) Environ Mol Mutagen, 54, pp. 719-736 | |
| dc.description | Nielsen, T., Jørgensen, H.E., Larsen, J.C., Poulsen, M., City air pollution of polycyclic aromatic hydrocarbons and other mutagens: Occurrence, sources and health effects (1996) Sci Total Environ, 189-190, pp. 41-49 | |
| dc.description | Qu, Y.H., Xu, G.X., Zhou, J.Z., Chen, T.D., Zhu, L.F., Shields, P.G., Wang, H.W., Gao, Y.T., Genotoxicity of heated cooking oil vapors (1992) Mutat Res, 298, pp. 105-111 | |
| dc.description | Reifferscheid, G., Buchinger, S., Cell-based genotoxicity testing: Genetically modified and genetically engineered bacteria in environmental genotoxicology (2009) Adv Biochem Eng Biotechnol, 118, pp. 85-111 | |
| dc.description | Rosenkranz, H.S., Mermelstein, R., Mutagenicity and genotoxicity of nitroarenes: All nitro-containing chemicals were not created equal (1983) Mutat Res, 114, pp. 217-267 | |
| dc.description | São Paulo. . Lei Estadual no 11.241 - Dispõe sobre a eliminação gradativa da queima da palha da cana-de-açúcar e dá providências correlatas (2002), 112, pp. 2-3. , D.O.E. São Paulo, Seção ISato, M.I.Z., Umbuzeiro, G.A., Coimbão, C.A., Coelho, M.C.L.S., Sanches, P.S., Alonso, C.D., Martins, M.T., Mutagenicity of airborne particulate organic material from urban and industrial areas of São Paulo, Brazil (1995) Mutat Res, 335, pp. 317-330 | |
| dc.description | Sharma, A.K., Jensen, K.A., Rank, J., White, P.A., Lundstedt, S., Gagne, R., Jacobsen, N.R., Wallin, H., Genotoxicity, inflammation and physico-chemical properties of fine particle samples from an incineration energy plant and urban air (2007) Mutat Res, 633, pp. 95-111 | |
| dc.description | Simmon, V.F., In vitro mutagenicity assays of chemical carcinogens and related compounds with Salmonella typhimurium (1979) J Natl Cancer Inst, 62, pp. 893-899 | |
| dc.description | Skopek, T.R., Liber, H.L., Kaden, D.A., Thilly, W.G., Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium (1978) Proc Natl Acad Sci USA, 75, pp. 4465-4469 | |
| dc.description | Srogi, K., Monitoring of environmental exposure to polycyclic aromatic hydrocarbons: A review (2007) Environ Chem Lett, 5, pp. 169-195 | |
| dc.description | Stevens, R.K., Lewis, C.W., Dzubau, T.G., Cupitt, L.T., Lewtas, J., Sources of mutagenic activity in urban fine particles (1990) Toxicol Ind Health, 6, pp. 81-94 | |
| dc.description | Umbuzeiro, G.A., Franco, A., Magalhães, D., Castro, F.J.V., Kummrow, F., Rech, C.M., Carvalho, L.R.F., Vasconcellos, P.C., A preliminary characterization of the mutagenicity of air particulate matter collected during sugar cane harvesting using the Salmonella/microsome microsuspension assay (2008) Environ Mol Mutagen, 49, pp. 249-255 | |
| dc.description | Umbuzeiro, G.A., Franco, A., Martins, M.H., Kummrow, F., Carvalho, L.R.F., Schmeiser, H.H., Leykauf, J., Claxton, L.D., Mutagenicity and DNA adduct formation of PAH, nitro-PAH, and oxy-PAH fractions of air particulate matter from São Paulo, Brazil (2008) Mutat Res, 652, pp. 72-80 | |
| dc.description | Umbuzeiro, G.A., Machala, M., Weiss, J., Diagnostic tools for effect-directed analysis of mutagens, AhR agonists, and endocrine disruptors (2011) Effect-Directed Analysis of Complex Environmental Contamination, pp. 69-82. , Brack W, editor. . Heidelberg: Spring-Verlag | |
| dc.description | Umbuzeiro, G.A., Kummrow, F., Morales, D.A., Alves, D.K.M., Lim, H., Jarvis, I.W.H., Bergvall, C., Dreij, K., Sensitivity of Salmonella YG5161for detecting PAH-associated mutagenicity in air particulate matter (2014) Environ Mol Mutagen, 55, pp. 510-517 | |
| dc.description | Vargas, V.M.F., Mutagenic activity as a parameter to assess ambient air quality for protection of the environment and human health (2003) Mutat Res, 544, pp. 313-319 | |
| dc.description | Viras, L.G., Athanasiou, K., Siskos, P.A., Determination of mutagenic activity of airborne particulates and of the benzo[α]pyrene concentrations in Athens atmosphere (1990) Atmos Environ, 24B, pp. 267-274 | |
| dc.description | Walgraeve, C., Demeestere, K., Dewulf, J., Zimmermann, R., Van Langenhove, H., Oxygenated polycyclic aromatic hydrocarbons in atmospheric particulate matter: Molecular characterization and occurrence (2010) Atmos Environ, 44, pp. 1831-1846 | |
| dc.description | Walker, G.C., Plasmid (pKM101)-Mediated Enhancement of Repair and Mutagenesis: Dependence on Chromosomal Genes in Escherichia coli K-12 (1977) Mol Gen Genet, 152, pp. 93-103 | |
| dc.description | | |
| dc.description | | |
| dc.language | en | |
| dc.publisher | John Wiley and Sons Inc. | |
| dc.relation | Environmental and Molecular Mutagenesis | |
| dc.rights | embargo | |
| dc.source | Scopus | |
| dc.title | Mutagenicity Profile Of Atmospheric Particulate Matter In A Small Urban Center Subjected To Airborne Emission From Vehicle Traffic And Sugar Cane Burning | |
| dc.type | Artículos de revistas | |
