A Dopant For Improved Sensitivity In Easy Ambient Sonic-spray Ionization Mass Spectrometry.

dc.creatorSantos, Jandyson M
dc.creatorVendramini, Pedro H
dc.creatorSchwab, Nicolas V
dc.creatorEberlin, Marcos N
dc.creatorde Morais, Damila R
dc.date2016-Jan
dc.date2016-05-23T19:44:02Z
dc.date2016-05-23T19:44:02Z
dc.date.accessioned2018-03-29T01:31:09Z
dc.date.available2018-03-29T01:31:09Z
dc.identifierJournal Of Mass Spectrometry : Jms. v. 51, n. 1, p. 53-61, 2016-Jan.
dc.identifier1096-9888
dc.identifier10.1002/jms.3726
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1002/jms.3726/abstract
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/236120
dc.identifier26757072
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1304363
dc.descriptionRecently, 3-nitrobenzonitrile (3-NBN) has been used to improve sensitivity of sonic-spray ionization mass spectrometry. Easy ambient sonic-spray ionization (EASI) is one of the simplest, gentlest and most used spray-based desorption/ionization ambient techniques, but limited sensitivity has been commonly taken as its major drawback. Herein we investigate the use of 3-NBN as a dopant in EASI-MS for improved sensitivity. Using a few typical EASI samples as test cases, the presence of 10 ppm (µg ml(-1) ) of 3-NBN in the spray solvent showed two to fourfold gains in EASI-MS sensitivity as measured both by total ion current and S/N ratios, accompanied with significant reductions in chemical noise. Sensitivity for DESI using 3-NBN as a dopant also improved and dopant DESI versus dopant EASI sensitivities were compared. The use of solvent dopants seems therefore to be a promising strategy to improve sensitivity for spray-based ambient MS techniques. Copyright © 2015 John Wiley & Sons, Ltd.
dc.description51
dc.description53-61
dc.languageeng
dc.relationJournal Of Mass Spectrometry : Jms
dc.relationJ Mass Spectrom
dc.rightsfechado
dc.sourcePubMed
dc.subject3-nitrobenzonitrile And Mass Spectrometry
dc.subjectDesi-ms
dc.subjectEasi-ms
dc.subjectDopant
dc.titleA Dopant For Improved Sensitivity In Easy Ambient Sonic-spray Ionization Mass Spectrometry.
dc.typeArtículos de revistas


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