Tautomerism In 8-nitroguanosine Studied By Nmr And Theoretical Calculations.

dc.creatorBarbosa, Thaís M
dc.creatorRittner, Roberto
dc.creatorAlexander, Katie
dc.creatorCosstick, Richard
dc.creatorAbraham, Raymond J
dc.date2016-Jan
dc.date2016-05-23T19:43:53Z
dc.date2016-05-23T19:43:53Z
dc.date.accessioned2018-03-29T01:31:00Z
dc.date.available2018-03-29T01:31:00Z
dc.identifierNucleosides, Nucleotides & Nucleic Acids. v. 35, n. 2, p. 1-11, 2016-Jan.
dc.identifier1532-2335
dc.identifier10.1080/15257770.2015.1114127
dc.identifierhttp://www.tandfonline.com/doi/abs/10.1080/15257770.2015.1114127
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/236084
dc.identifier26810486
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1304327
dc.descriptionThe guanine base in DNA, due to its low oxidation potential, is particularly sensitive to chemical modifications. A large number of guanine lesions have been characterized and studied in some detail due to their relationship with tissue inflammations. Nevertheless, one example of these lesions is the formation of 8-nitro-guanosine, but the NMR data of this compound was only partially interpreted. A comprehensive study of the two possible tautomeric forms, through a detailed characterization of this compound, has implications for its base pairing properties. The target compound was obtained through a synthetic sequence of five steps, where all intermediates were fully characterized using spectral data. The analysis of the two tautomers was then evaluated through NMR spectroscopy and theoretical calculations of the chemical shifts and NH coupling constants, which were also compared with the data from guanosine.
dc.description35
dc.description1-11
dc.languageeng
dc.relationNucleosides, Nucleotides & Nucleic Acids
dc.relationNucleosides Nucleotides Nucleic Acids
dc.rightsembargo
dc.sourcePubMed
dc.subjectDna Lesions
dc.subjectNmr
dc.subjectNitroguanosine
dc.subjectTheoretical Calculations
dc.titleTautomerism In 8-nitroguanosine Studied By Nmr And Theoretical Calculations.
dc.typeArtículos de revistas


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