Membranous Nephropathy And Cerebellar Degeneration With Anti-gad Antibodies In Type 2 Diabetes Mellitus.

dc.creatorFolli, Franco
dc.creatorDaniele, Giuseppe
dc.creatorWerner, Sherry
dc.creatorKamath, Subash
dc.creatorMunera, Jose Velez
dc.creatorAbboud, Hanna
dc.creatorFanti, Paolo
dc.date2015-Oct
dc.date2016-05-23T19:43:32Z
dc.date2016-05-23T19:43:32Z
dc.date.accessioned2018-03-29T01:30:40Z
dc.date.available2018-03-29T01:30:40Z
dc.identifierActa Diabetologica. v. 52, n. 5, p. 897-903, 2015-Oct.
dc.identifier1432-5233
dc.identifier10.1007/s00592-015-0728-x
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25753172
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/235996
dc.identifier25753172
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1304239
dc.descriptionTo study the potential pathogenic significance of the coexistence of membranous nephropathy, cerebellar degeneration and anti-glutamic acid decarboxylase (GAD) autoantibodies in patients with diabetes. We performed a direct immunocytochemistry on human kidney slides, electron microscopy on human kidney biopsy, direct immunofluorescence on human kidney biopsy. Baboon and rat kidney cell lines were fractionated and subjected to western blotting with antibodies to GAD. In this patient we demonstrate the presence of autoantibodies to GAD, which is highly enriched in podocytes plasma membrane and tubular cells of the kidney as well as sub-endothelial IgG and complement C3 deposits in the glomerular basement membrane (GBM). We hypothesize the existence in this patient of a common autoimmune pathogenic mechanism with GAD as the autoantigenic determinant, underlying cerebellar degeneration and membranous nephropathy.
dc.description52
dc.description897-903
dc.languageeng
dc.relationActa Diabetologica
dc.relationActa Diabetol
dc.rightsfechado
dc.sourcePubMed
dc.subjectAnti-glutamic Acid Decarboxylase (gad) Autoantibodies
dc.subjectCerebellar Degeneration
dc.subjectMembranous Nephropathy
dc.subjectType 2 Diabetes Mellitus
dc.titleMembranous Nephropathy And Cerebellar Degeneration With Anti-gad Antibodies In Type 2 Diabetes Mellitus.
dc.typeArtículos de revistas


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