dc.creatorde Aguiar, Marcus A M
dc.creatorSchneider, David M
dc.creatordo Carmo, Eduardo
dc.creatorCampos, Paulo R A
dc.creatorMartins, Ayana B
dc.date2015-Jun
dc.date2016-05-23T19:43:20Z
dc.date2016-05-23T19:43:20Z
dc.date.accessioned2018-03-29T01:30:31Z
dc.date.available2018-03-29T01:30:31Z
dc.identifierJournal Of Theoretical Biology. v. 374, p. 48-53, 2015-Jun.
dc.identifier1095-8541
dc.identifier10.1016/j.jtbi.2015.03.028
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25843218
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/235952
dc.identifier25843218
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1304195
dc.descriptionOrganisms are often more likely to exchange genetic information with others that are similar to themselves. One of the most widely accepted mechanisms of RNA virus recombination requires substantial sequence similarity between the parental RNAs and is termed similarity-essential recombination. This mechanism may be considered analogous to assortative mating, an important form of non-random mating that can be found in animals and plants. Here we study the dynamics of haplotype frequencies in populations evolving under similarity-essential recombination. Haplotypes are represented by a genome of B biallelic loci and the Hamming distance between individuals is used as a criterion for recombination. We derive the evolution equations for the haplotype frequencies assuming that recombination does not occur if the genetic distance is larger than a critical value G and that mutation occurs at a rate μ per locus. Additionally, uniform crossover is considered. Although no fitness is directly associated to the haplotypes, we show that frequency-dependent selection emerges dynamically and governs the haplotype distribution. A critical mutation rate μc can be identified as the error threshold transition, beyond which this selective information cannot be stored. For μ<μc the distribution consists of a dominant sequence surrounded by a cloud of closely related sequences, characterizing a quasispecies. For μ>μc the distribution becomes uniform, with all haplotypes having the same frequency. In the case of extreme assortativeness, where individuals only recombine with others identical to themselves (G=0), the error threshold results μc=1/4, independently of the genome size. For weak assortativity (G=B-1)μc=2(-(B+1)) and for the case of no assortativity (G=B) μc=0. We compute the mutation threshold for 0<G<B and show that, for large B, it depends only on the ratio G/B. We discuss the consequences of these results for recombination in viruses and for speciation.
dc.description374
dc.description48-53
dc.languageeng
dc.relationJournal Of Theoretical Biology
dc.relationJ. Theor. Biol.
dc.rightsembargo
dc.sourcePubMed
dc.subjectFrequency-dependent Selection
dc.subjectHaplotype Frequencies
dc.subjectNeutral Models
dc.subjectQuasispecies Theory
dc.titleError Catastrophe In Populations Under Similarity-essential Recombination.
dc.typeArtículos de revistas


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