Peri-intraventricular Hemorrhage And Oxidative And Inflammatory Stress Markers In Very-low Birth Weight Newborns.

dc.creatorCaldas, Jamil P S
dc.creatorBraghini, Carolina A
dc.creatorMazzola, Taís N
dc.creatorVilela, Maria M S
dc.creatorMarba, Sérgio T M
dc.date
dc.date2016-05-23T19:43:05Z
dc.date2016-05-23T19:43:05Z
dc.date.accessioned2018-03-29T01:30:16Z
dc.date.available2018-03-29T01:30:16Z
dc.identifierJornal De Pediatria. v. 91, n. 4, p. 373-379
dc.identifier1678-4782
dc.identifier10.1016/j.jped.2014.09.008
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25913045
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/235889
dc.identifier25913045
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1304132
dc.descriptionTo evaluate the association between oxidative and inflammatory stress markers with peri-intraventricular hemorrhage (PIVH) in very-low birth weight newborns. This was a prospective study conducted in a level III neonatal unit. Basal and stimulated reactive oxygen intermediates (ROIs), reduced glutathione (GSH), and interleukin-6 (IL-6) levels were measured in umbilical cord blood. Newborns underwent serial ultrasound at the bedside, at 6, 12, 24, and 72hours of life and at seven days for the diagnosis of PIVH, classified as grades I to IV. Two groups were assessed, those with and without PIVH; maternal and neonatal control variables were used for comparison. Univariate and multiple regression analyses were applied. A total of 125 newborns were assessed. PIVH incidence rate was 12.0%. In the univariate analysis, basal ROI, the use of two or more doses of corticosteroids, birth weight<1,000g, ventilatory support use, and SNAPPE II value ≥ 22 were significantly associated with PIVH. However, in the multivariate analysis, only antenatal steroid use was independently associated with the disease (OR 0,194; 95% CI: 0,048 to 0,773; p=0,02). ROI, GSH, and IL-6 levels were not associated with the occurrence of PIVH in very-low birth weight infants.
dc.description91
dc.description373-379
dc.languageeng
dc.relationJornal De Pediatria
dc.relationJ Pediatr (Rio J)
dc.rightsfechado
dc.sourcePubMed
dc.subjectEspécies De Oxigênio Reativas
dc.subjectEstresse Oxidativo
dc.subjectGlutathione
dc.subjectGlutationa
dc.subjectHemorragia Cerebral
dc.subjectInterleucina-6
dc.subjectInterleukin-6
dc.subjectIntraventricular Hemorrhage
dc.subjectNewborn
dc.subjectOxidative Stress
dc.subjectReactive Oxygen Species
dc.subjectRecém-nascido
dc.titlePeri-intraventricular Hemorrhage And Oxidative And Inflammatory Stress Markers In Very-low Birth Weight Newborns.
dc.typeArtículos de revistas


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