Phenolic Compounds Of Hibiscus Sabdariffa And Influence Of Organic Residues On Its Antioxidant And Antitumoral Properties.

dc.creatorFormagio, A S N
dc.creatorRamos, D D
dc.creatorVieira, M C
dc.creatorRamalho, S R
dc.creatorSilva, M M
dc.creatorZárate, N A H
dc.creatorFoglio, M A
dc.creatorCarvalho, J E
dc.date
dc.date2016-05-23T19:42:57Z
dc.date2016-05-23T19:42:57Z
dc.date.accessioned2018-03-29T01:30:09Z
dc.date.available2018-03-29T01:30:09Z
dc.identifierBrazilian Journal Of Biology = Revista Brasleira De Biologia. v. 75, n. 1, p. 69-76
dc.identifier1678-4375
dc.identifier10.1590/1519-6984.07413
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25945622
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/235853
dc.identifier25945622
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1304096
dc.descriptionThe aim of this study was to evaluate the phenolic and flavonoids contents and the antioxidant and antitumoral activity of leaf and calyx methanolic extracts from Hibiscus sabdariffa (roselle) cultivated with poultry litter and organosuper® under three modes of application. The total phenolic content in the each extract was determined using the Folin-Ciocalteu reagent and for aluminium chloride flavonoids. The antioxidant parameters were analyzed using a 2, 2-diphenyl-1-picrylhydrazyl (DPPH.) free radical scavenging assay. An antitumor colorimetric assay using sulforhodamine B. The highest contents of phenolic and flavonoids were observed in leaf extracts (389.98 and 104.52 mg g-1, respectively) and calyx extracts (474.09 and 148.35 mg g-1, respectively) from plants cultivated with organosuper®, although these values did not differ significantly from those observed for the other treatments. The average IC50 of leaves (43.48 μg mL-1) and calyces (37.15 μg mL-1) demonstrated that both have substances that may contribute to free radical scavenging action. The methanol extract from calyces showed significant selective activity against a leukemia line (K-562), with IC50 values of 0.12 mg mL-1 (organosuper®) and 1.16 mg mL-1 (poultry litter), with concentration-dependent, cytotoxic and cytocidal effects.
dc.description75
dc.description69-76
dc.languageeng
dc.relationBrazilian Journal Of Biology = Revista Brasleira De Biologia
dc.relationBraz J Biol
dc.rightsfechado
dc.sourcePubMed
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectAntioxidants
dc.subjectCell Line, Tumor
dc.subjectCell Proliferation
dc.subjectDrug Screening Assays, Antitumor
dc.subjectHibiscus
dc.subjectHumans
dc.subjectPhenols
dc.subjectPlant Extracts
dc.subjectPlant Leaves
dc.titlePhenolic Compounds Of Hibiscus Sabdariffa And Influence Of Organic Residues On Its Antioxidant And Antitumoral Properties.
dc.typeArtículos de revistas


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