[influence Of Polymorphisms Of The Beta-2 Adrenergic Receptor On The Presence Of Exercise-induced Bronchospasm In Adolescents].

dc.creatorConsentino, Cássio Leandro Mühe
dc.creatorFurtado-Alle, Lupe
dc.creatorSilva, Larissa Rosa da
dc.creatorLopes, Wendell Arthur
dc.creatorTureck, Luciane Viater
dc.creatorMilano, Gerusa Einsfeld
dc.creatorLazarotto, Leilane
dc.creatorCavaglieri, Cláudia Regina
dc.creatorLeite, Neiva
dc.date2015-Oct
dc.date2016-05-23T19:42:50Z
dc.date2016-05-23T19:42:50Z
dc.date.accessioned2018-03-29T01:30:04Z
dc.date.available2018-03-29T01:30:04Z
dc.identifierRevista Paulista De Pediatria : Orgao Oficial Da Sociedade De Pediatria De Sao Paulo. v. 34, n. 1, 2015-Oct.
dc.identifier1984-0462
dc.identifier10.1016/j.rpped.2015.06.002
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/26684442
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/235832
dc.identifier26684442
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1304075
dc.descriptionTo determine the influence of polymorphisms of the beta-2 adrenergic receptor (ADRB2) in triggering exercise-induced bronchospasm (EIB) in adolescents. The subjects were divided into two groups: present EIB (EIB+) (n=45) and absent EIB (EIB-) (n=115). The bronchial provocation test with exercise was performed with a protocol that consisted of walking/running for at least eight minutes at high intensity, i.e., >85% of maximum heart rate, considering EIB+ as a 10% decrease in forced expiratory volume in one second (FEV1). The genotyping of the ADRB2 gene was performed by the Taqman method, using the Step One Plus system. Independent t-test, Mann-Whitney and Chi-square tests, as well as Spearman's correlation coefficient were used for the statistical analysis. Age, body weight, height, FEV1, FVC and FEV1/FVC ratio were lower in the EIB+ group when compared to EIB- (p<0.05). There were no significant differences in the proportion of the allele at position 27 and Arg16Gly and Gln27Glu genotypes between the EIB+ and EIB- groups (p=0.26; p=0.97 and p=0.43, respectively). However, there was a trend towards statistical significance regarding the greater proportion of the Gly16 allele for the EIB+ when compared to the EIB- group (p=0.08). The presence of polymorphisms associated with the Glu27 allele and Arg16Gly and Gln27Glu genotypes had no influence on EIB. However, the statistical trend towards greater frequency of the Gly16 allele in individuals with EIB+ can be considered evidence of the influence of polymorphisms of the ADBR2 gene on EIB in adolescents.
dc.description34
dc.description
dc.languagepor
dc.relationRevista Paulista De Pediatria : Orgao Oficial Da Sociedade De Pediatria De Sao Paulo
dc.relationRev Paul Pediatr
dc.rightsfechado
dc.sourcePubMed
dc.subjectAdrb2 Gene
dc.subjectAdolescent
dc.subjectAdolescente
dc.subjectBroncoespasmo Induzido Pelo Exercício
dc.subjectExercise‐induced Bronchospasm
dc.subjectGene Adrb2
dc.title[influence Of Polymorphisms Of The Beta-2 Adrenergic Receptor On The Presence Of Exercise-induced Bronchospasm In Adolescents].
dc.typeArtículos de revistas


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