| dc.creator | Brandão, Marcelo M | |
| dc.creator | Spoladore, Larissa | |
| dc.creator | Faria, Luzinete C B | |
| dc.creator | Rocha, Andréa S L | |
| dc.creator | Silva-Filho, Marcio C | |
| dc.creator | Palazzo, Reginaldo | |
| dc.date | 2015 | |
| dc.date | 2016-05-23T19:41:52Z | |
| dc.date | 2016-05-23T19:41:52Z | |
| dc.date.accessioned | 2018-03-29T01:29:16Z | |
| dc.date.available | 2018-03-29T01:29:16Z | |
| dc.identifier | Scientific Reports. v. 5, p. 12051, 2015. | |
| dc.identifier | 2045-2322 | |
| dc.identifier | 10.1038/srep12051 | |
| dc.identifier | http://www.nature.com/articles/srep12051 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/235628 | |
| dc.identifier | 26159228 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1303871 | |
| dc.description | A previously described DNA sequence generator algorithm (DNA-SGA) using error-correcting codes has been employed as a computational tool to address the evolutionary pathway of the genetic code. The code-generated sequence alignment demonstrated that a residue mutation revealed by the code can be found in the same position in sequences of distantly related taxa. Furthermore, the code-generated sequences do not promote amino acid changes in the deviant genomes through codon reassignment. A Bayesian evolutionary analysis of both code-generated and homologous sequences of the Arabidopsis thaliana malate dehydrogenase gene indicates an approximately 1 MYA divergence time from the MDH code-generated sequence node to its paralogous sequences. The DNA-SGA helps to determine the plesiomorphic state of DNA sequences because a single nucleotide alteration often occurs in distantly related taxa and can be found in the alternative codon patterns of noncanonical genetic codes. As a consequence, the algorithm may reveal an earlier stage of the evolution of the standard code. | |
| dc.description | 5 | |
| dc.description | 12051 | |
| dc.language | eng | |
| dc.relation | Scientific Reports | |
| dc.relation | Sci Rep | |
| dc.rights | aberto | |
| dc.source | PubMed | |
| dc.title | Ancient Dna Sequence Revealed By Error-correcting Codes. | |
| dc.type | Artículos de revistas | |
