Facing Hymenoptera Venom Allergy: From Natural To Recombinant Allergens.

dc.creatorPerez-Riverol, Amilcar
dc.creatorJusto-Jacomini, Débora Lais
dc.creatorZollner, Ricardo de Lima
dc.creatorBrochetto-Braga, Márcia Regina
dc.date2015-Jul
dc.date2016-05-23T19:41:46Z
dc.date2016-05-23T19:41:46Z
dc.date.accessioned2018-03-29T01:29:11Z
dc.date.available2018-03-29T01:29:11Z
dc.identifierToxins. v. 7, n. 7, p. 2551-2570, 2015-Jul.
dc.identifier2072-6651
dc.identifier10.3390/toxins7072551
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/?term=26184309
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/235608
dc.identifier26184309
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1303851
dc.descriptionAlong with food and drug allergic reactions, a Hymenoptera insect Sting (Apoidea, Vespidae, Formicidae) is one of the most common causes of anaphylaxis worldwide. Diagnoses of Hymenoptera venom allergy (HVA) and specific immunotherapy (SIT) have been based on the use of crude venom extracts. However, the incidence of cross-reactivity and low levels of sensibility during diagnosis, as well as the occurrence of nonspecific sensitization and undesired side effects during SIT, encourage the search for novel allergenic materials. Recombinant allergens are an interesting approach to improve allergy diagnosis and SIT because they circumvent major problems associated with the use of crude venom. Production of recombinant allergens depends on the profound molecular characterization of the natural counterpart by combining some omics approaches with high-throughput screening techniques and the selection of an appropriate system for heterologous expression. To date, several clinically relevant allergens and novel venom toxins have been identified, cloned and characterized, enabling a better understanding of the whole allergenic and envenoming processes. Here, we review recent findings on identification, molecular characterization and recombinant expression of Hymenoptera venom allergens and on the evaluation of these heterologous proteins as valuable tools for tackling remaining pitfalls on HVA diagnosis and immunotherapy.
dc.description7
dc.description2551-2570
dc.languageeng
dc.relationToxins
dc.relationToxins (Basel)
dc.rightsaberto
dc.sourcePubMed
dc.subjectHymenoptera Venom
dc.subjectAllergy
dc.subjectDiagnosis
dc.subjectImmunotherapy
dc.subjectRecombinant Allergens
dc.subject“omics” Approaches
dc.titleFacing Hymenoptera Venom Allergy: From Natural To Recombinant Allergens.
dc.typeArtículos de revistas


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